Heterociclos con nitrógeno (N)

<p>Applications 1-cyclopropyl-3-phenylpiperazine (cas# 1248907-49-4) is a useful research chemical.<br></p>

<p>Applications Pentafluoropyridine (cas# 700-16-3) is a useful research chemical.<br></p>

<p>Applications 4-Butylpiperidine Hydrochloride is an intermediate in the synthesis of AC 42 (A115600), an allosteric agonist of acetylcholine orthosteric site.<br>References Jacobson, M.A., et al: Mol. Pharmacol., 78, 648 (2010);<br></p>

<p>Applications 5-Bromo-2-aminopyrimidine (cas# 7752-82-1) is a compound useful in organic synthesis.<br>References Robins, M., et al.: J. Med. Chem., 50, 3897 (2007),<br></p>

<p>Applications 6-Bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one is used as a reactant in the preparation of pyrido[2,3-d]pyrimidin-7-one derivatives as selective inhibitors of cyclin-dependent kinases 4 and 6.<br>References VanderWel, S., et al.: J. Med. Chem., 48, 2371 (2005); Toogood, P., et al.: J. Med. Chem., 48, 2388 (2005);<br></p>

<p>Applications 1,1'-Ethylenedipiperazine Hydrochloride Salt is the salt form of 1,1'-Ethylenedipiperazine, which is used in the synthetic preparation of novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazoles as anticancer agents.<br>References Zhang, R.; et al.: Bioorganic Med. Chem., 19, 7023 (2011)<br></p>

<p>Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications 2-Chloromethyl-3,5-dimethylpyridin-4-ol (cas# 220771-03-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-ethoxy-3-ethylpyrazine (cas# 35243-43-7) is a useful research chemical.<br></p>

<p>Applications Methyl 6-aminopyridazine-3-carboxylate<br></p>

<p>Applications 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (cas# 903550-26-5) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>

<p>Stability Hygroscopic<br>Applications 5-Benzyl-1H-imidazole (cas# 4238-72-6) is a useful research chemical.<br></p>

<p>Applications 4-Benzoyl-1H-pyrrole-2-carboxylic Acid (cas# 15372-84-6) is a useful research chemical.<br></p>

<p>Applications 3-aminoisoxazole-4-carbonitrile (cas# 258518-65-9) is a useful research chemical.<br></p>

<p>Applications 1-Phenyl-pyrazole 4-pyruvic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Impurity Olmesartan Imidazole Diethyl Ester Impurity<br>Applications An intermediate in the synthesis of Olmesartan Medoxomil. (O550000)<br></p>

<p>Applications Ethyl Imidazole-2-carboxylate is an intermediate used to synthesize tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). It is also used to prepare imidazoindenopyrazinone carboxylic acid derivatives as AMPA antagonists with anticonvulsant activities.<br>References Miyashiro, J., et al.: Bioorg. Med. Chem. Lett., 19, 4050 (2009); Pratt, J., et al.: Bioorg. Med. Chem. Lett., 10, 2749 (2000)<br></p>

<p>Applications 3-Bromo-5-pyrrolidinophenylboronic acid<br></p>

<p>Applications 1,2-Bis(2-(4,5-dihydro-1H-imidazol-2-yl)propan-2-yl)diazene Dihydrochloride is used as an initiator in the synthesis of ultra heigh relative molecular mass polyarcrylamide.<br>References Wang, L., et. al.: Hecheng Shuzhi Ji Suliao, 31, 37 (2014)<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxamide<br></p>

<p>Applications 4,6-Diamino-2-chloro-5-pyrimidinecarbonitrile is an intermediate in the synthesis of 2,4,6-Triamino-5-pyrimidinecarbonitrile is a photodegradation product of two isostructural pesticides in aqueous solution: Cyromazine (C989300) and Dicyclanil.<br>References Kimbrough, R., et al.: Environ. Sci. Technol., 30, 908 (1996), Root, D., et al.: Pesticide Sci., 48, 25 (1996), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000),<br></p>

<p>Applications Benzotriazol-1-ylacetic Acid is used as a reagent in the synthesis of benzotriazole imidazoline compounds which are used as metal corrosion inhibitors. Benzotriazol-1-ylacetic Acid is also a reagent in the synthesis of N-(benzo[1,2,3]triazol-1-yl)-N-((benzyl)acetamido)phenyl carboxamides which are used as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors.<br>References Turlington, M., et al.: Bioorg, Med. Chem. Lett., 23, 6172 (2013); Chen, Y., et al.: Faming Zhuanli Shenqing. CN 103664902 A 20140326. Mar 26, 2014<br></p>

<p>Applications Methyl 4-Methylpyrrole-2-carboxylate is a useful reagent for preparation of (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives, a novel class of glycine site antagonists.<br>References Balsamini, C., et al.: J. Med. Chem., 41, 808 (1998);<br></p>

<p>Applications 2,5,6-Triaminopyrimidin-4(1H)-one sulphate (cas# 39267-74-8) is a useful research chemical.<br></p>

<p>Applications N-Boc-4-(aminomethyl)piperidine is a protected 4-substituted piperidinecarboxylate used in the preparation of orally active platelet-activating factor antagonists as well as other biologically active compounds.<br>References Carceller, E. et al.: J. Med. Chem., 39, 487 (1996);<br></p>

<p>Applications Used in the preparation of Ifosfamide and Ifosfamide analogs.<br></p>

<p>Applications 6-Phenoxypyridin-3-amine (cas# 25194-67-6) is a useful research chemical.<br></p>

<p>Applications 4-(Trifluoromethyl)-2-pyrimidinecarboxylic Acid is used as a reactant in the preparation of piperazine derivatives to be used as mGluR5 receptor positive allosteric modulators.<br>References Heimann, Annekatrin, et al.: PCT Int. Appl., WO 2013087805 A1 20130620 (2013)<br></p>

<p>Applications 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole is a useful reagent for developing dipeptidyl peptidase IV inhibitors for treatment or prevention of diabetes.<br>References Nakajima, Y., et al.: J. Mol. Cell Cardiol., 129, 257-265 (2019)<br></p>

<p>Applications Methyl 5-Bromo-1H-pyrrole-2-carboxylate is a chemical reagent used in pharmaceutical synthesis.<br>References Wang, M. et al.: Org. Biomol. Chem., 11, 2574 (2013); Xiang, H. et al.: RSC Adv., 3, 5807 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Methyl 1-BOC-(2S,4S)-4-Aminopyrrolidine-2-carboxylate<br></p>

<p>Applications 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetic Acid is a reactant or reagent used in the synthesis of the blood coagulating enzyme factor Xa (FXa) inhibitor.<br>References Xue, T., et al.: J. Med. Chem., 57, 7770 (2014);<br></p>

<p>Applications 3,5-Dimethyl-1-phenyl-1H-pyrazole is a reactant used in the synthesis of hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents.<br>References Chenna, V., et. al.: J. Environ. Sci. Heal. A., 49, 641 (2014)<br></p>

<p>Applications (4-Chlorophenyl)-4-piperidinylmethanone Hydrochloride (cas# 55695-51-7) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Fluoropyrrolidine HCl<br></p>

<p>Applications 2,5,6-Triamino-4(3H)-pyrimidinone Sulfate is used in the preparation of guanines and other purine derivatives with antiviral activities.<br>References Hemmati, S. et al.: Int. J. Chem. Sci., 2, 9 (2004); Chetsanga, C.J. et al.: Chem.-Biol. inter., 58, 117 (1986);<br></p>

<p>Applications 5-[4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.<br></p>

<p>Applications Lithium (3-fluoro-6-methylpyridin-2-yl)trihydroxyborate, is a building block used in the synthesis of chemical compounds.<br></p>

<p>Applications Intermediate for heterocyclic compounds as tyrosine kinase inhibitors and anticancer agents.<br>References McLean, A., et al.: J. Chem. Phys., 72, 5639 (1980), Watts, J., et al.: J. Biol. Chem., 276, 43197 (2001),<br></p>

<p>Applications 6'-Amino-1,6-dihydro-2-methyl-6-oxo[3,3'-bipyridine]-5-carbonitrile is a reagent used in the preparation of cardiotonic agents.<br>References Yamanaka, M. et al.: Chem. Pharm. Bull., 40, 666 (1992);<br></p>

<p>Applications [1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid (cas# 1043903-19-0) is a useful research chemical.<br></p>

<p>Applications 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide is an intermediate in synthesizing T-705RTP (T003210), a derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. T-705RTP which has the triphosphate group, gets strongly inhibited by the influenza virus RNA polymerase activity in comparison with T-705RMP (T003202).<br>References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010);<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Applications 2-chloro-6-(piperidin-1-yl)pyridine (cas# 19946-28-2) is a useful research chemical.<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 1-(3-Bromopropyl)-4-(4-chlorophenyl)piperazine is an intermediate in the synthesis of 2-​[3-​[4-​(4-​Chlorophenyl)​-​1-​piperazinyl]​propyl]​-1,​2,​4-triazolo[4,​3-​a]​pyridin-​3(2H)​-​one Hydrochloride (C433100), which is a related compound of Trazodone (T718500), which is an antidepressant.<br>References Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970), Brogden, R.N., et al.: Drugs, 21, 401 (1981), Gorecki, D., et al.: Anal. Profiles Drug Subs., 16, 693 (1986),<br></p>

<p>Applications An intermediate in the production of Rosuvastatin (R700500) derivatives.<br>References Liu, Y. et al.: Guang. Huag., 39, 54 (2011);<br></p>

<p>Applications tert-butyl 6-chloropyridazine-3-carboxylate (cas# 1340506-55-9) is a useful research chemical.<br></p>

<p>Applications 2-PHENYLPIPERAZINE 2HCL (cas# 872139-22-5) is a useful research chemical.<br></p>

<p>Applications 2-Chloromethyl-3H-benzoimidazole-5-carbonitrile (cas# 150613-50-6) is a useful research chemical.<br></p>

<p>Applications 1-ethyl-6-oxopiperidine-3-carboxylic acid (cas# 915919-82-3) is a useful research chemical.<br></p>

<p>Applications Pyrrole-ND (CAS# 10162-82-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.<br>References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014<br></p>

<p>Applications Isoxazolo[5,4-b]pyridin-3-amine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>