Heterociclos con nitrógeno (N)

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 1-(4-aminophenyl)imidazolidin-2-one (cas# 89518-99-0) is a useful research chemical.<br></p>

<p>Applications tert-butyl 6-chloropyridazine-3-carboxylate (cas# 1340506-55-9) is a useful research chemical.<br></p>

<p>Applications 2-PHENYLPIPERAZINE 2HCL (cas# 872139-22-5) is a useful research chemical.<br></p>

<p>Applications 4-(chloromethyl)-2-phenyl-1,3-oxazole (cas# 30494-97-4) is a useful research chemical.<br></p>

<p>Applications Diethyl Pyridine-2,3-dicarboxylate is a useful reagent in preparation of herbicides.<br>References Doehner, R.: Eur. Pat. Appl. (1988), EP 254951 A2 19880203.<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications 2,3-Dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine is used in the preparation of a pluripotent stem cell inhibitor.<br>References Furukawa, Yusuke. et al., Jichi Medical University(2019);<br></p>

<p>Applications Sulfosuccinimidyl Palmitate Sodium is an analog of Sulfosuccinimidyl Oleate Sodium (S689200).<br></p>

<p>Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.<br>References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014<br></p>

<p>Applications Isoxazolo[5,4-b]pyridin-3-amine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.<br></p>

<p>Stability Hygroscopic<br>Applications 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride (cas# 1187830-76-7) is a useful research chemical.<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.<br>References Gonzalez C., et al.: J. Med. Chem., 55, 11022 (2012); Cooper, A. B., et al.: Bioorg. Med. Chem. Lett., 27, 4471 (2017)<br></p>

<p>Applications 4-Hydroxypiperidine-d9 is labelled 4-Hydroxypiperidine (H950845) which is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)<br></p>

<p>Applications 1,3-benzoxazol-6-ol (cas# 106050-81-1) is a useful research chemical.<br></p>

<p>Applications 6-Methyl-3-pyridoyl-2-pyrrolidinone (cas# 1076198-57-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Cyclohexyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Pyrimidinemethanamine (cas# 75985-45-4) is a useful research chemical.<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials.<br>References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);<br></p>

<p>Applications 4-(3,5-Dimethylpyrazol-1-yl)phenylboronic acid, pinacol ester<br></p>

<p>Applications [5-(pyridin-2-yl)-1H-imidazol-2-yl]methanamine trihydrochloride (cas# 2060007-34-1) is a useful research chemical.<br></p>

<p>Applications 2-hydroxy-N-pyridin-3-ylbenzamide (cas# 118623-71-5) is a useful research chemical.<br></p>

<p>Applications 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester is used in various studies of stimulators of soluble guanylate cyclase.<br>References Straub, A., et al.: Bioorg. Med. Chem. Lett., 11, 781 (2001); Mittendorf, J., et al.: ChemMedChem, 4, 853 (2009); Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002)<br></p>

<p>Applications 5-Bromo-3-methylpicolinic Acid is used to prepare oxazine derivatives as BACE inhibitors useful in treatment of neurological disorders.<br>References Badiger, S., et al.: PCT Int. Appl., WO 2011009943 A1 20110127 (2011); Tintelnot-Blomley, M., et al.: PCT Int. Appl., WO 2011080176 A1 20110707 (2011)<br></p>

<p>Applications Dimethylhydrazone-1-methyl-4-piperidinone is an intermediate in the synthesis of α-Meprodine Hydrochloride (M224950), which is a narcotic analgesic. An analogue of Proline (P755300).<br>References Iorio, M.A., et al.: J. Med. Chem., 20, 309 (1977),<br></p>

<p>Applications The hydrochloride salt of 1-(4-Fluoro-benzyl)-2-piperazin-1-yl-1H-benzoimidazole (CAS:142617-98-9) which is related to Astemizole(A790030) a histamine H1-receptor antagonist.<br>References Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000)<br></p>

<p>Applications 2-Fluoropyridine acts as a reagent in the synthesis of aminopyrimidines with antimicrobial and antifungal properties.<br>References Hedidi, M., et al.: Eur. J. Org. Chem., 39, 5903 (2017)<br></p>

<p>Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxy-2-piperidinone is a synthetic intermediate in the synthesis of pharmaceutical goods.<br>References Vink, M.K.S., et al.: J. Org. Chem., 67, 7869 (2002);<br></p>

<p>Applications Methyl 1-[(2-Fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carboximidate is a useful reactant to study metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.<br>References Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002);<br></p>

<p>Applications An intermediate for the synthesis of Alpidem.<br></p>

<p>Applications An aromatic intermediate compound useful for the preparation of substituted melamine, ammelides, and ammelines.<br>References Sunaga, S., Bioorg. Med. Chem., 14, 4217 (2006),<br></p>

<p>Applications Pyrrolidine-3-carboxylic acid (cas# 59378-87-9) is a useful research chemical.<br></p>

<p>Applications dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate (cas# 23705-85-3) is a useful research chemical.<br></p>

<p>Applications 5-(2-Pyridyl)-1,2-dihydropyridin-2-one is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission.<br>References Hibi, S. et al.: J. Med. Chem., 55, 10584 (2012); McElhinny, C. et al.: Synthesis, 44, 57 (2012);<br></p>

<p>Applications L-threo-α-Phenyl-2-piperidineacetamide-d10 is an labelled intermediate in the synthesis of labelled L-threo-Ritalinic Acid (R533132).<br>References Chavan, A.B. et al.: Otg. Proc. Res. Dev., 14, 1473 (2010);<br></p>

<p>Applications 6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.<br>References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003); Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004); Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004); Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)<br></p>

<p>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N is an isotope labelled spin-labelling compound.<br></p>

<p>Applications 1-Phenyl-1H-tetrazole-5-thiol is used as a corrosion inhibitor and as a reagent in the synthesis of Microcarpalide, a microfilament disrupting agent that is weakly cytotoxic to mammalian cells.<br>References Chermahini, A., et al.: Struct. Chem., 22, 175 (2011); Murga, J., et al.: Org. Lett., 4, 3447 (2002); Ratnayake, A., et al.: Org. Lett., 3, 3479 (2001)<br></p>

<p>Applications Ethyl 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylate is an intermediate used in the synthesis of 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic Acid (M339120), which is an impurity of the drug Amphetamine (A634248).<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 5-Bromo-2-cyano-3-(trifluoromethyl)pyridine<br></p>

<p>Applications A useful synthetic intermediate<br></p>

<p>Applications 4-(Difluoromethoxy)piperidine (cas# 1147107-39-8) is a useful research chemical.<br></p>

<p>Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.<br>References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)<br></p>

<p>Applications 2-Amino-3-bromopyrazine-5-carboxylic Acid (cas# 887352-34-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-((3,3-Difluorocyclobutyl)methoxy)pyridin-4-yl)methanamine is a useful intermediate for organic synthesis.<br></p>

<p>Applications An intermediate in the preparation of serotonin 5-HT2a receptor antagonists<br>References Ullrich, T., et al.: Bioorg. Med. Chem., 8, 2427 (2000),<br></p>

<p>Applications α-Butyl-α-(2,4-dichlorophenyl)-4H-1,2,4-triazole-4-ethanol is a useful synthetic intermediate.<br></p>

<p>Applications 1,2-benzisoxazol-3-amine (cas# 36216-80-5) is a useful research chemical.<br></p>

<p>Applications 5-(4’-Benzyloxyphenyl)-2-oxazolidone (cas# 88693-98-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Bromopicolinic acid<br></p>