Heterociclos con nitrógeno (N)

<p>Applications ethyl (3-bromo-1H-pyrazol-1-yl)acetate (cas# 1427022-51-2) is a useful research chemical.<br></p>

<p>Applications 1-(4-aminophenyl)imidazolidin-2-one (cas# 89518-99-0) is a useful research chemical.<br></p>

<p>Applications 2,5-Dioxopyrrolidin-1-yl dodecanoate (cas# 14565-47-0) is a useful research chemical.<br></p>

<p>Applications 2-[[6-Amino-5-(4-bromophenyl)-4-pyrimidinyl]oxy]-ethanol is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications 3-Chloro-6-ethynylpyridazine is an pyridazine triflate intermediate used for the preparation of (alkynyl)pyridazine.<br>References Toussaint, D., et al.: Acta. Chimica, Slovenica., 41, 253 (1994);<br></p>

<p>Applications 1,2-Diphenyl-3,5-pyrazolidinedione is a reactant used in organic synthesis such as in the preparation of inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase.<br>References Gilbert, A. et al.: J. Med. Chem., 49, 6027 (2006); Fernandez, Is. et al.: J. Am. Chem. Soc., 131, 11875 (2009);<br></p>

<p>Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.<br>References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014<br></p>

<p>Applications 6-Bromopiperonal is a disubstituted 1,3-benzodioxole that displayed synergistic activity with carbaryl on houseflies. 6-Bromopiperonal is used as an intermediate in the preparation of GPR30-selective agonist G-1.<br>References Wilkinson, C.F. et al.: J. Agric. Food Chem., 15, 139 (1967): Hewlett, P.S. et al.: J. Sci. Food Agric., 18, 279 (1967); Burai, R. et al.: Org. Biomol. Chem., 8, 2252 (2010);<br></p>

<p>Applications 2-(3-Aminophenyl)pyridine Dihydrochloride<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine-15N4 is an intermediate in the synthesis of 2’-Deoxyguanosine-5N5 which is a nucleoside.<br>References Krenitsky, T.A., et al.: Biochemistry, 20, 3615 (1981), Chapeau, M.-C., et al.: Chem. Res. Toxicol., 4, 636 (1991),<br></p>

<p>Applications [3-(2-Amino-6-methoxy-4-pyrimidinyl)phenyl](3,6-dihydro-4-methyl-1(2H)-pyridinyl)-methanone is a useful chemical for cancer immunotherapy research.<br></p>

<p>Applications 1,3-benzoxazol-6-ol (cas# 106050-81-1) is a useful research chemical.<br></p>

<p>Applications 6-Methyl-3-pyridoyl-2-pyrrolidinone (cas# 1076198-57-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Desamino-6-oxo Phenazopyridine is a Phenazopyridine (P313751) degradation product/impurity, and is a useful synthetic intermediate.<br>References Nickerson, B., et al.: J. Liq. Chromatogr., 18, 3947 (1995)<br></p>

<p>Applications 2-Pyrimidinemethanamine (cas# 75985-45-4) is a useful research chemical.<br></p>

<p>Applications 6-ACETYL-PICOLINIC ACID ETHYL ESTER (cas# 114578-70-0) is a useful research chemical.<br></p>

<p>Applications 6-Methyl-3-pyridinol is a reagent in the preparation of anilino(pyridyl)quinolinecarbonitriles which has Src kinase inhibitiion and antitumor properties.<br>References Zhang, N., et al.: Bioorg. Med. Chem. Lett., 19, 5071 (2009); Blume-Jensen, P., et al.: Nature, 411, 355 (2001)<br></p>

<p>Stability Light Sensitive<br>Applications A reagent for the determination of aldehydes and other reactive chemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dickinson, R.G. and Jacobsen,N.W. : Chem. Commun., 1719, (1970), Del Nozal, M.J. et al.: J. Liq. Chromatography, 16, 1105 (1993),<br></p>

<p>Applications 5-[2-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxylic acid (cas# 1003561-80-5) is a useful research chemical.<br></p>

<p>Applications 5-Nitro-2-(propylthio)pyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications Ethyl-2-ethoxy-1-[[(2'-cyanobiphenyl-4-yl) methyl] benzimidazole]-7-carboxylate<br></p>

<p>Applications 6-Methyl-3-pyridineacetonitrile is a reactant used in the preparation of pyrazolopyrimidine derivatives as agents for treatment of autoimmune diseases and orally active corticotropin-releasing factor receptor antagonists.<br>References Chen, C. et al.: J. Med. Chem., 47, 4787 (2004)<br></p>

<p>Applications The preparation and incorporation of 2-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]acetic Acid into the bilayers of liposomal constructs used for immunization with synthetic peptides.<br>References Frisch, B., et al.: Bioconjugate Chem., 7, 180-186 (1996)<br></p>

<p>Applications 4,6-Dichloro-5-fluoropyrimidine<br></p>

<p>Applications (S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine is a disubstituted pyrrolidine. (S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine undergoes condensation reactions with carbonyl compounds to produce hydrazones which are useful for highly enantioselective synthesis.<br>References Enders, D. et al.: Tetrahed. Lett., 2, 191 (1977); Zakharova, V. et al.: Zeitsch. Naturforsch. B Chem. Sci., 61, 464 ·2006);<br></p>

<p>Applications 4-(azetidin-3-yl)-4H-1,2,4-triazole (cas# 1495939-85-9) is a useful research chemical.<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants.<br>References Flather, M., et al.: Lancet, 355, 1575 (2000); Sasso, F., et al.: Metabolism, 52, 675 (2003); Kass, D., et al.: Circ. Res., 94, 1533 (2004); Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006); Hahn, M., et al.: Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al.: Angew. Chem. Int. Ed., 51, 3699 (2012);<br></p>

<p>Applications 2-Fluoropyridine acts as a reagent in the synthesis of aminopyrimidines with antimicrobial and antifungal properties.<br>References Hedidi, M., et al.: Eur. J. Org. Chem., 39, 5903 (2017)<br></p>

<p>Applications An intermediate in the preparation of serotonin 5-HT2a receptor antagonists<br>References Ullrich, T., et al.: Bioorg. Med. Chem., 8, 2427 (2000),<br></p>

<p>Applications 6-bromo-5-iodopyridine-3-carboxylic acid (cas# 1200130-82-0) is a useful research chemical.<br></p>

<p>Applications 2-(3,5-Dichlorophenyl)-imidazo[1,2-a]pyridine is derived from Ethyl Bromoacetate (E900140), which is used in the synthesis of metabolites of carcinogenic PAHs. Also it is used in the preparation of steroidal antiestrogens through cyclic condensation. A reactant in the preparation of antimicrobial and antioxidant coumarinyloxymethyl-thiadiazolone.<br>References Wu, A. et al.: Tetrahedron, 68, 7217 (2012); Clark, E. et al.: J. Med. Chem., 20, 1096 (1977); Al-Amiery, A. et al.: Chem. Nat. Comp., 48, 950 (2013);<br></p>

<p>Applications 2-Amino-3-bromopyrazine-5-carboxylic Acid (cas# 887352-34-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Pyridin-2-yl-propan-2-one is an antimicrobial bioactive compound extracted from Lactarius vellereus fermenting liquor.<br>References Ji, H., et al.: Beijing Linye Daxue Xuebao, 30, 92 (2008); Song, R., et al.: From Faming Zhuanli Shenqing (2008), CN 101230368 A 20080730;<br></p>

<p>Applications (2-((3,3-Difluorocyclobutyl)methoxy)pyridin-4-yl)methanamine is a useful intermediate for organic synthesis.<br></p>

<p>Applications (4S)​- 5,​5-​Dimethyl-​2-​[[[(5-​methyl-​3-​phenyl-​4-​isoxazolyl)​carbonyl]​amino]​methyl]​-4-​thiazolidinecarboxyl​ic acid is a useful reactant.<br></p>

<p>Applications 1-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid (cas# 911463-81-5) is a useful research chemical.<br></p>

<p>Applications PIPERONYL ACETONE (cas# 55418-52-5) is a useful research chemical.<br></p>

<p>Applications 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine Dihydrochloride is a useful reagent for synthesis of the bicyclic secondary amines via dimethylaminomethylene derivatives of 3-pyrrolidone and 3-piperidone.<br>References Fukui, H., et al.: Heterocycles, 56, 257 (2002);<br></p>

<p>Applications 4-Amino-2,6-dichloropyridine (cas# 2587-02-2) is a compound useful in organic synthesis.<br>References Altenbach, R., et al.: J. Med. Chem., 51, 6571 (2008), Namba, K., et al.: Bioorg. Med. Chem., 16, 6131 (2008),<br></p>

<p>Applications 2-(3-chlorophenyl)pyrimidine-4-carboxylic acid (cas# 1216604-60-2) is a useful research chemical.<br></p>

<p>Applications 3-Bromopropionic Acid N-Hydroxysuccinimide (cas# 101314-84-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(Difluoromethoxy)piperidine (cas# 1147107-39-8) is a useful research chemical.<br></p>

<p>Applications trans-4-Fluoropyrrolidine-2-carboxylic Acid-13C1 Hydrochloride Salt is an isotopic analog of (2S,4R)-4-Fluoropyrrolidine-2-carboxylic Acid (F594640).<br></p>

<p>Applications methyl 2-amino-5-benzyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-3-carboxylate (cas# 1428234-04-1) is a useful research chemical.<br></p>

<p>Applications 2,3-Diaminopyridine is used as a reagent in the synthesis of novel imidazopyridine derivatives which can exhibit cytotoxic activity against MCF-7 human breast adenocarcinoma cell line. 2,3-Diaminopyridine is also used in the preparation of non-camptothecin topoisomerase I inhibitors which exhibit antitumor activity.<br>References Puskullu, M.O., et al.: Chem. Heterocyc. Compd., 51, 723 (2015); Zhang, C., et al.: Bioorg. Med. Chem. Lett., 25, 4693 (2015)<br></p>

<p>Applications 6-Amino-2,4-dihydroxypyrimidine (cas# 873-83-6) is a compound useful in organic synthesis.<br>References Ghahremanzadeh, R., et al.: Chem. Pharm. Bull., 56, 1617 (2008), Bharate, S., et al.: Bioorg. Med. Chem., 16, 7167 (2008), Reigan, P., et al.: Eur. J. Med. Chem., 43, 1248 (2008),<br></p>

<p>Applications N-Boc-4-(aminomethyl)piperidine is a protected 4-substituted piperidinecarboxylate used in the preparation of orally active platelet-activating factor antagonists as well as other biologically active compounds.<br>References Carceller, E. et al.: J. Med. Chem., 39, 487 (1996);<br></p>

<p>Applications 4,5-Dimethyl-4H-1,2,4-triazole-3-acetic Acid is a useful synthetic intermediate.<br></p>

<p>Applications 4-Chloro-2-(trifluoromethoxy)pyrimidine (cas# 1261494-46-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylate is an intermediate used in the synthesis of 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic Acid (M339120), which is an impurity of the drug Amphetamine (A634248).<br></p>

<p>Applications 4-(Trifluoromethyl)-2-pyrimidinecarboxylic Acid is used as a reactant in the preparation of piperazine derivatives to be used as mGluR5 receptor positive allosteric modulators.<br>References Heimann, Annekatrin, et al.: PCT Int. Appl., WO 2013087805 A1 20130620 (2013)<br></p>

<p>Applications Pyrrole-2,3,4,5-d4 (CAS# 17767-94-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole is a useful reagent for developing dipeptidyl peptidase IV inhibitors for treatment or prevention of diabetes.<br>References Nakajima, Y., et al.: J. Mol. Cell Cardiol., 129, 257-265 (2019)<br></p>

<p>Applications Methyl (αS)-α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate is the essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>

<p>Applications 2-[3-(chloromethyl)phenyl]pyrimidine (cas# 898289-51-5) is a useful research chemical.<br></p>

<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>