Compuestos heterocíclicos

<p>Applications pyridazin-4-ylmethanol (cas# 50901-43-4) is a useful research chemical.<br></p>

<p>Applications Ethyl 1-Piperazine-d8-acetate 2HCl is a useful isotopically labeled compound<br></p>

<p>Applications N-Nitroso-3-hydroxy Pyrrolidone is an N-Nitroso impurity, Nitrosamines are known carcinogens in a wide range of animal species.<br>References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985)<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Slama, J.T., et al.: Biochemistry, 27, 183 (1988) (2) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (3) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications 2-(Thiophen-2-yl)acetamide is used in preparation of [18F]Maleimide-based Glycogen synthase kinase-3β ligands for positron emission tomography imaging.<br>References Lee, Katarzyna N., et al.: PCT Int. Appl., (2018);<br></p>

<p>Stability Hygroscopic<br>Applications 3-(1-Nitroethyl)-2-benzofuran-1(3H)-one (cas# 79017-08-6) is a useful research chemical.<br></p>

<p>Applications Tetrahydrofuran-2,5-dicarboxylic acid (CAS# 6338-43-8) is a useful research chemical compound.<br></p>