Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Spiro[1,3-dioxolane-2,8'-pentacyclo[5.4.0.0²,⁶.0³,¹⁰.0⁵,⁹]undecan]-11'-one is an organic compound that has a ketal group in its structure. It is also a hydrogen bond donor and a reductive coupling agent with properties of intramolecular hydrogen bonding and dimerization. The intramolecular hydrogen can be found in the ring of the spiro[1,3-dioxolane-2,8'-pentacyclo[5.4.0.0²,⁶.0³,¹⁰.0⁵,⁹]undecan]-11'-one that is bonded to the ketal group as well as on the benzene ring on the other side of the molecule when it is bound to another spiro[1

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Formyl-N,N-dimethyl-benzamide is a potent tyrosine kinase inhibitor. It is a pyridine derivative that binds to the ATP binding site of the enzyme and inhibits its activity. This results in decreased cellular proliferation and lower levels of protein synthesis. 4-Formyl-N,N-dimethyl-benzamide has shown to be effective at inhibiting the growth of tumour cells when combined with chemotherapy, but has not been evaluated for efficacy in treating other diseases. The pharmacokinetic profile of this drug is not well known, as it has not been studied in humans.br>

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Amino-N-(2-aminophenyl)-benzamide (4ANAP) is a small molecule that inhibits inflammatory bowel disease. It has been shown to have anti-inflammatory effects and to be a potential biomarker for colorectal adenocarcinoma. 4ANAP binds to the EGF receptor on the cell surface, which prevents its activation by EGF and thereby blocks cellular proliferation. 4ANAP has been shown to bind with high affinity to other receptors such as those found in autoimmune diseases and cancer cells. The anti-inflammatory properties of 4ANAP are due to its ability to inhibit the production of proinflammatory cytokines such as IL1β, IL6, TNFα, and IL8. This drug also inhibits the production of reactive oxygen species in neutrophils and macrophages, thereby reducing oxidative injury in inflamed tissues.

Versatile small molecule scaffold

Versatile small molecule scaffold

Ritonavir is a protease inhibitor that belongs to the class of HIV-1 protease inhibitors. It inhibits the activity of the virus by binding to the active site of the enzyme and blocking it from cleaving proteins. Ritonavir is used with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART). This drug is also used in combination with other protease inhibitors, such as indinavir and saquinavir, to treat HIV infections that are resistant to these drugs. In some cases, ritonavir can be administered without a booster agent such as cobicistat or lopinavir/ritonavir. This drug has been shown to have pharmacokinetic parameters that are similar in healthy volunteers and patients infected with HIV-1.