Building Blocks

<p>3-Methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine is a purine ligand that can be protonated at the N7 nitrogen. It has been shown to have biological properties such as anion binding and also shows strong dichroism spectra. The structure of 3-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine has been determined by X-ray crystallography and magnetic resonance spectroscopy. This ligand is not easily protonated in aqueous solution due to its high basicity. The protonation state of this ligand is sensitive to pH changes in the environment.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>6-Chloro-2-oxo-1,2-dihydropyridine-4-carboxylic acid (6CODPC) is a carboxylic acid that is an active ingredient in some fungicides. It has been shown to inhibit the growth of certain plant pathogens such as viruses and bacteria. 6CODPC binds to the enzyme ribonucleotide reductase, which is involved in DNA synthesis and replication, leading to the inhibition of RNA synthesis and protein synthesis. This leads to cell death by apoptosis. 6CODPC also inhibits the production of proteins in plants that are necessary for photosynthesis.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>2-(3-Methylbenzyl)succinic acid is a sulfate metabolite that has been shown to regulate the activity of sulfate-reducing bacteria. It was first identified as a major metabolite in incubations with benzylsuccinic acid and xylene. The isomers of 2-(3-methylbenzyl)succinic acid are benzoate and hydroxyphthalide. The geochemical significance of this compound is not yet known, but it may signify the presence of microbial metabolism in the environment. The compound can be found at nanomolar concentrations in natural environments and has been shown to inhibit microbial growth by mechanisms that remain unclear.</p>

4-Methylbenzylsuccinic acid is a metabolite of benzoic acid and other aromatic compounds. It is a precursor in the biosynthesis of 4-methylphenol, which is used as a biocide in cosmetics, plastics, and textiles. The conversion of 4-methylbenzylsuccinic acid to 4-methylphenol occurs by way of 2 methyl groups that are added to the molecule by sulfate reductase. The enzymes fumarate reductase and sulfide oxidoreductase are involved in the conversion of 4-methylbenzylsuccinic acid to 4-methylphenol. In addition, this compound is converted to an intermediate in the biosynthesis of pyrrole, which can be used as an antioxidant or as a precursor for other molecules.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

1-naphthalen-2-ylpropan-1-one is a linear acyl compound that is used in the synthesis of other compounds. It reacts with propanoic acid to form 1,2-diphenylethane. The reaction also produces an acylation product and propanoic acid as a byproduct. This reaction is an example of an acylation reaction, which is the process of adding an organic acid group to a hydrocarbon molecule. The result of this reaction is shown in the diagram below.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>5-(4-Methoxy-benzylidene)-thiazolidine-2,4-dione is a drug that binds to the transcription factor NF-κB and prevents its translocation into the nucleus. It is used in the treatment of inflammatory diseases such as rheumatoid arthritis, psoriasis, and Crohn's disease. 5-(4-Methoxy-benzylidene)-thiazolidine-2,4-dione also has hepatoprotective effects by inhibiting oxidative stress and proinflammatory cytokines. This drug can be administered orally or intravenously.</p>

<p>N-Benzylpyridine-4-carboxamide is a synthetic compound that has been shown to have anticancer, anti-inflammatory, and neuropathic properties. This compound is an innovative drug candidate for the treatment of inflammatory diseases and cancer. N-Benzylpyridine-4-carboxamide inhibits the production of chemokines, which are cytokines that are involved in the recruitment of cells to sites of inflammation and infection. The mechanism involves the ring opening of the amide bond between the nitro group and the carboxylic acid group. The pharmacophore is derived from this ring opening reaction. This compound also blocks receptor subtypes such as 5HT3A or NMDA receptors, which may lead to neuropathic effects.</p>

4-(4-Oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)benzoic acid (L-OTSA) is a potent inhibitor of the uptake of potassium ions into cells. It binds to the extracellular surface of the cell membrane and prevents potassium from entering the cell. This results in hyperpolarization of the membrane potential and an increase in spontaneous activity. L-OTSA also induces electrophysiological effects such as increased spontaneous activity, decreased action potential duration, and increased threshold for excitation. L-OTSA has been found to inhibit cellular uptake of potassium ions.

<p>2-(4-Benzoylphenoxy)acetic acid is a phenoxy compound that can be used as an antinociceptive agent. It has been shown to inhibit the pain response in mice by binding to the peripheral cannabinoid receptor CB2 and blocking intracellular calcium channels, thereby inhibiting the release of pro-inflammatory molecules. 2-(4-Benzoylphenoxy)acetic acid also inhibits the activity of two enzymes involved in carbonic acid production and glucose metabolism, which may provide protection against metabolic disorders. Computational methods have been used to model the molecular structure of 2-(4-benzoylphenoxy)acetic acid, which are then compared with experimental data on hydrogen bonding interactions between dihedral angles and intramolecular hydrogen bonds.</p>

<p>4-Chlorophenyl-1-(3-chloropropyl)piperazine dihydrochloride (PCPP) is a drug that is used in the treatment of Parkinson's disease. It has been shown to be an effective replacement for levodopa, which is the most common treatment for Parkinson's disease and other dopamine-related disorders. PCPP does not have any effect on the levels of dopamine or other neurotransmitters in the brain, but it does inhibit the enzymes that break down dopamine and other neurotransmitters. As a result, PCPP prevents or reduces symptoms of Parkinson's disease and other dopamine-related disorders.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-5-chloro-3-nitrobenzoic acid is a synthetic compound that has been shown to have topoisomerase activity. It binds to the DNA of cancer cells and inhibits the expression of certain genes, which inhibits cell proliferation. 2-Amino-5-chloro-3-nitrobenzoic acid also interacts with the drug transport protein p-glycoprotein, inhibiting its function and leading to multidrug resistance in cancer cells. This drug has been shown to be cytotoxic for lung carcinoma cells.</p>

3-Bromo-4-hydroxy-5-methoxybenzoic acid is an organic compound that is a chlorinated derivative of benzoic acid. It can be synthesized by the reaction between benzene and sodium hypochlorite in the presence of a nuclear reactor. The reaction produces 3-bromo-4,5-dihydroxyphenylacetic acid which reacts with chlorine to produce 3,4,5-trichlorobenzoic acid. This compound can then be oxidized to form 3-bromo-4,5-dihydroxybenzoic acid or chlorinated to form 3,4,5,6 -tetrachlorobenzoic acid. The latter compound has been used as a precursor for herbicides such as Benlate and Clorox.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>5-Cyclohexyl-5-methylimidazolidine-2,4-dione is a ligand that binds to the receptor and activates it. It is used in research as a tool for studying ion channels, peptides, and protein interactions. 5-Cyclohexyl-5-methylimidazolidine-2,4-dione has been shown to inhibit the binding of an antibody to its antigen.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

5-Bromo-1-methylpyrimidine-2,4(1H,3H)-dione is a group p2 enhancement agent that can be used to enhance radiation damage. It has been shown to interact with radiation under 13c-nmr spectroscopy and x-ray diffraction studies. 5-Bromo-1-methylpyrimidine-2,4(1H,3H)-dione can also act as a radical chain or radical in the presence of reactive oxygen species. The ph profile of 5-Bromo-1-methylpyrimidine-2,4(1H,3H)-dione has been studied and it was found that this compound was stable in acidic conditions but unstable in basic conditions. The nmr spectra of 5-Bromo-1-methylpyrimidine 2,4(1H,3H)-dione have been studied and proton signals were observed at 1.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Bis(2-phenylethyl)amine hydrochloride (BPEA) is a compound that has been shown to have neuroprotective effects in animal models of Alzheimer's disease. This compound has been found to inhibit the formation of reactive oxygen species, which are responsible for neuronal cell death. BPEA also inhibits the enzyme amine oxidase, which is responsible for the breakdown of neurotransmitters and may be involved in the development of Alzheimer's disease and other neurodegenerative diseases. BPEA has been shown to be effective in preventing and treating symptoms of Alzheimer's disease in an experimental model. Dipropylamine (DPEA), a known inhibitor of amine oxidase, was tested with BPEA and found to have synergistic effects. DPBA was not able to prevent or treat symptoms when given alone.</p>

2-(4-Chlorophenyl)acetophenone is a synthetic compound that has been used in the synthesis of other compounds. It has been shown to have affinity for chloride ions and can be used as a substitute for hydrochloric acid. 2-(4-Chlorophenyl)acetophenone has been shown to react with sodium hydroxide in a stepwise manner, forming sodium chloride as an intermediate product. This reaction is believed to be due to the high nucleophilicity of chlorine ions. The molecular descriptors of this compound include four bonds, one ring, two heteroatoms, and two double bonds. This chemical also displays functional theory characteristics such as elimination and leishmania inhibition.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

4-Isopropylbenzenesulfonamide is a compound that belongs to the class of antifungals. It is an intramolecular inhibitor of the enzyme, target molecules, that catalyzes the formation of ergosterol in fungi. The inhibition of this enzyme leads to the accumulation of squalene and other sterols, which causes cell death. 4-Isopropylbenzenesulfonamide also has x-ray diffraction studies that have shown its ability to inhibit germination of spores from some fungi.

<p>Versatile small molecule scaffold</p>

<p>Nitrosodioctylamine is a polycarboxylic acid that is used for the production of chlorinated hydrocarbons. It is also used as an industrial chemical and a polymerization inhibitor. Nitrosodioctylamine can be synthesized from hydrogen chloride and nitric acid, or from sodium nitrate and sulfuric acid. The polymerization inhibition activity of this compound is due to its ability to form cross-links with polyvinyl alcohol. Nitrosodioctylamine has been shown to cause cancer in rats, which may be due to its ability to bind with DNA and inhibit the synthesis of enzyme proteins. Nitrosodioctylamine has also been found to have a sealant effect on metal surfaces that are contaminated by halogen compounds such as chlorine and bromine because it reacts with these compounds to form a layer of insoluble organic material.</p>

<p>Bismuthiol II is a reagent that is used in the reaction mechanism of particle. It reacts with hydrochloric acid to form silver chloride, which can be detected by fluorescence probe. Bismuthiol II is also used as a plasma mass spectrometry (PMS) reagent, where it reacts with tellurium to form copper tellurate and bismuth tellurate. Bismuthiol II has been shown to have anti-cancer effects on cancer tissue during the extractant process. The extractant process utilizes a multi-walled carbon nanotube (MWCNT) to extract copper complexes from the tissue. This extraction process has been shown to enhance the analytical chemistry of bismuthiol II.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>This is a pyridine compound that is used in the nitration of aromatic compounds. It can be synthesized by reaction of 2-aminopyridine with nitric acid and sulfuric acid, followed by filtration and recrystallization. The experimental procedure for this compound is not currently available.</p>

1-Methyl-4-nitro-1H-imidazole-5-sulfonamide is a cytotoxic agent that is used to treat cancer. This drug inhibits the growth of cancer cells and sensitizes them to radiation therapy by binding to DNA, which inhibits its ability to replicate. It has been shown to have an inhibitory effect on tumour growth in animal models. 1-Methyl-4-nitro-1H-imidazole-5-sulfonamide binds preferentially to tissues with high oxygen tension, such as the brain and bone marrow, and has been shown to be effective in treating leukemia cells. 1MM4NIAS is also radiosensitizing for cancer and can be used in combination with radiation therapy treatments for cancer patients.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

6-Acetyl-1,2,3,4-tetrahydropyrimidine-2,4-dione is a chemical compound that has two functions. One function is as a dianion that can be used to measure the hydrogen ion concentration in an aqueous solution with the pH range of 1 to 14. The second function is as an acid complex with constant K1 and K2 values. This compound is stable in the presence of acids and bases and can react with alcohols to form esters. 6-Acetyl-1,2,3,4-tetrahydropyrimidine-2,4-dione has been used in the synthesis of orotic acid from orotic acid esters.

1-Benzoylpyrrolidine-2,5-dione is a ketone that can be used as an industrial coupling agent. It is used in the synthesis of saccharin and arylketones. This reagent can be used to cleave amides and succinimide esters. 1-Benzoylpyrrolidine-2,5-dione reacts with arylsiloxanes to form functional groups on the silicon atom. In addition, this compound can be used as a substrate for organic synthesis.

Versatile small molecule scaffold

2-[2-(Hydroxymethyl)phenyl]ethan-1-ol is an antibacterial agent that belongs to the group of aryl alcohols. It is a bactericidal agent that inhibits the growth and reproduction of bacteria by binding to their DNA. 2-[2-(Hydroxymethyl)phenyl]ethan-1-ol has shown effectiveness against gram-positive and gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae and Bacillus subtilis. This compound has also been shown to be active against Mycobacterium tuberculosis, but not against Candida albicans or Aspergillus niger.

<p>2-Amino-3,4,6-trichlorophenol is a versatile compound that has various applications in different fields. It is commonly used in chromatographic analysis as a reference standard and as a reagent in organic synthesis. This compound is also found naturally in plants such as monoterpenoids, isoflavones, pyrazoles, alkaloids, and chalcones. Additionally, it has been identified as a component of certain research chemicals.</p>

4-Chloro-2,5-dimethoxyaniline (4CMA) is a synthetic organic compound that can be used in the synthesis of dyes and pharmaceuticals. This compound is synthesized by reacting ammonium nitrate with 4-chloro-2,5-dimethoxybenzene in the presence of sodium formate. The reaction takes place in an organic solvent such as xylene or sulfoxide. The product is then reacted with methyl alcohol and alkylation agent such as hydrogen chloride to produce the desired product.

<p>Ethyl 3-cyano-3-phenylpyruvate is a chemical compound that is used as an antiviral agent. It has been shown in vitro to inhibit influenza virus and depression. Ethyl 3-cyano-3-phenylpyruvate is synthesized by the alkylation of furyl with phenyl group, followed by the reduction of the tetronic acid formed. The antiviral activity of ethyl 3-cyano-3-phenylpyruvate was analyzed by assessing the ability to inhibit viral replication and production of new viruses. The sodium salt form of this compound is used in foodstuff as a preservative.</p>

<p>Sodium 5-sulphoisophthalate is a chemical compound that is the monosodium salt of sulfonated 5-sulphoisophthalic acid. It is an important raw material in the production of polycarboxylic acids, which are used as intermediates in the production of nylon and polyester. The reaction vessel for the production of sodium 5-sulfoisophthalate is usually a stainless steel pressure reactor. Sodium carbonate and sulfur trioxide react at high temperatures to produce sodium 5-sulfoisophthalate and hydrogen sulfide. The product can be purified by fractional distillation, or it can be reacted with ammonia to form ammonium sulfite, which can then be used as a fertilizer. Sodium 5-sulfoisophthalate has been shown to have fluorescence properties and can serve as a probe for hydrogen bonding between molecules.</p>

<p>(2S)-2-Acetamido-3-hydroxy-N-methylpropanamide is a compound that belongs to the class of phosphopeptides. It is synthesized by reacting an N-acetylcysteamine with methylamine in the presence of sodium bicarbonate. This compound has shown to have antihypertensive and vasodilatory effects, as well as the ability to inhibit platelet aggregation.</p>

<p>Tert-butyl 2-azidoacetate is a synthetic chemical that is used to synthesize azides. It reacts with ethyl diazoacetate to produce tert-butyl azide and tert-butanol. This reaction can be used to synthesize the azide functional group in a single step, which is more efficient than the traditional two-step process. Tert-butyl 2-azidoacetate has been shown to have antibacterial activity against hl-60 cells, an immortalized promyelocytic leukemia cell line. The antibacterial effect of tert-butyl 2-azidoacetate may be due to its ability to react with amino groups on proteins and phosphonates on DNA, which are important for bacterial growth and replication.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Acetaminophen, also known as paracetamol, is a widely used drug for pain relief and fever reduction. It is metabolized by the liver, mainly through the cytochrome P450 pathway. The cytochrome P450 pathway produces reactive intermediates that can cause oxidative stress and DNA damage. Acetaminophen has been shown to be toxic to rat primary hepatocytes in vitro at concentrations of 40-160 μM after 24 hours. Acetaminophen has also been shown to be mutagenic and carcinogenic in rats at doses of 5000 mg/kg/day, which is equivalent to a human dose of 160 mg/kg/day or higher. These effects are due to acetaminophen’s metabolic activation by reactive oxygen species (ROS) and its ability to induce cytotoxicity and oxidative stress in cells.</p>

<p>2'-Hydroxy-5'-methylacetanilide (HMA) is a methemoglobin-inducing agent that is used to study the uptake of acetylated compounds. HMA has been shown to have dose-dependent effects on methemoglobin production and can be used to study the interaction of active substances with hemoglobin. HMA is also used in preloaded doses as an antidote for exposure to nitrobenzene or phenacetin. This drug also induces monomers, which are small molecules that contain one or more acetyl groups, and suppresses the efflux of substances from cells. 2'-Hydroxy-5'-methylacetanilide is also known as acetoxybenzoic acid and has been shown to inhibit synaptic activity in rats.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>4-(Chloromethyl)-1-methoxy-2-nitrobenzene is a heterocyclic compound that belongs to the group of germicides. It is prepared by the reaction of potassium carbonate with methylamine and 4-chloro-1-methoxybenzene. The chloromethyl group in this compound can be replaced by other halogens, such as bromine or iodine, in order to produce other derivatives. This type of chemical has been used in the past as a fungicide, but is now mostly used as a precursor for dyes. 4-(Chloromethyl)-1-methoxy-2-nitrobenzene has an analogous reaction with amines, which are compounds containing nitrogen and hydrogen atoms that have one or more organic substituents. These reactions are useful for producing drugs such as amphetamines, barbiturates, and some types of antibiotics.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Nitrophenyl)oxirane is an organic compound that is used as a reactant in organic chemistry. It has been shown to be an effective anti-inflammatory agent in vitro. This compound reacts with the hydroxyl group of epoxyethane to form a stable oxirane, which can then be oxidized by hydrogen peroxide to form an epoxide. The enantiomeric purity of 2-(4-nitrophenyl)oxirane was determined using an asymmetric synthesis and found to be greater than 99%.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-oxohexanoate is a synthetic chemical that is used as a solvent in organic synthesis. It can be deuterated to produce a deuterated derivative, which has been shown to have improved stability in an organic environment. Methyl 2-oxohexanoate has been used as the starting material for the asymmetric synthesis of some medicinal drugs, including the anti-inflammatory drug piroxicam. This chemical also has been shown to have anticancer activity due to its ability to inhibit fatty acid synthase and nutrient uptake in pancreatic cancer cells.</p>

2-(Isopropylthio)aniline is a synthetic chemical compound. It is a primary alkyl amine, with the chemical formula CH3CH2NHCH2CH2SCH3. It has two alkyl groups, one substituent and one trifluoroacetic acid group. 2-(Isopropylthio)aniline is synthesized in the laboratory by reacting benzene with an aminophenyl group and an alkyl group. The reaction proceeds via the following steps: 1) Addition of trifluoroacetic acid to benzene 2) Addition of aminophenyl group to benzene 3) Addition of an alkyl group to benzene 4) Reaction of the newly formed 2-chloro-benzoyl chloride with ammonia 5) Reaction of the newly formed 2-aminobenzamide with hydrogen sulfide

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>The compound 1-benzyl-1H-1,2,3,4-tetrazol-5-amine is a tetrazole derivative that has been shown to inhibit the growth of gram negative bacteria. It inhibits bacterial growth by inhibiting the production of DnaA protein in the cytoplasm through coordination with a zinc ion. The compound has also been shown to be active against Gram positive bacteria and fungi, but not against yeast. The compound has also been shown to have minimal inhibitory concentrations against human fibroblast cells and science.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl oxazole-2-carboxylate is a cyclic, chiral, methyl ester. It is a congener of the drug Valine and has been shown to have antitumor potential. The methyl oxazole-2-carboxylate is an amide with a cyclic peptide backbone and is synthesized from valine by way of an enzymatic reaction that converts the amino acid into a chiral, cyclic amide. This compound has demonstrated anticancer properties in vitro and in vivo. Methyl oxazole-2-carboxylate also has antiangiogenic activity which may be due to its ability to inhibit protein synthesis in tumor cells.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(3,4-Dimethoxyphenyl)prop-2-en-1-ol is a phenolic compound that has been shown to have inhibitory properties in the human liver and hamster V79 cells. It also inhibits the growth of bacteria such as typhimurium and rat liver microsomes. 1-(3,4-dimethoxyphenyl)prop-2-en-1-ol shows reactive properties with sodium carbonate, which is used in the activation of esters. This compound is found in plants belonging to the family Rutaceae and it may be synthesized from 3,4-dimethoxybenzaldehyde by an enzymatic reaction involving alcohol dehydrogenase or cytochrome P450.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Procaine is a local anesthetic that is used to reduce the pain of needle insertion. It also has a bactericidal effect on staphylococcus and epidermidis, and is commonly used as a disinfectant for surgical instruments. Procaine can be detoxified by acetylation with phenoxyacetic acid to produce 4-(phenoxymethyl)benzoic acid, which has an increased spectrum of activity against bacteria. 4-(Phenoxymethyl)benzoic acid is active against methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant strains of bacteria. The antibiotic binds to bacterial DNA gyrase, preventing the synthesis of proteins necessary for cell division. This causes bacterial cells to die by inhibiting protein synthesis and cell division.

<p>(1-Phenylcyclopropyl)methanol is an aromatic ketone that can be used in the synthesis of oxazaborolidines. It has been proven to be a good substrate for asymmetric syntheses, which are often used for the development of enantioselective reactions. The mechanism of this reaction is not yet fully understood, but it is thought that the C-O bond in (1-phenylcyclopropyl)methanol reacts with acetophenone to form an intermediate diketone. This intermediate then reacts with an electrophile such as sodium methoxide or methyl iodide to produce the desired product.</p>

Versatile small molecule scaffold

<p>6-Chloro-1-methyluracil is a nucleophilic acylating agent that reacts with primary amines to form N,N'-acylureas. It also reacts with chloride to form chlorinated derivatives. 6-Chloro-1-methyluracil has been shown to react with hydrogen peroxide in an acid solution to produce cyclen and aldehydes. The reaction scheme is shown below:</p>

<p>Versatile small molecule scaffold</p>

<p>2-Pyrrol-1-ylbenzaldehyde is a molecule that is transformed to give the corresponding chloride and ketone. The transformation of 2-pyrrol-1-ylbenzaldehyde to the corresponding chloride and ketone is achieved by reaction with diethyl etherate, followed by treatment with acidified hydrochloric acid. This experiment was conducted in order to produce the cyclised compound intramolecularly by sequential halogenation. The synthesis of heterocycles can be achieved through olefination or pyridine ring formation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold