Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

1,2-Dibromoethane-1-sulfonyl fluoride is a sulfur-containing organic molecule that can be used as a connector in organic chemistry. It has been shown to yield a family of sulfonyl fluorides that are stable and have profiles that are suitable for drug discovery. These compounds are synthesized by the reaction of 1,2-dibromoethane with sodium sulfite and hydrofluoric acid. The synthesis of these compounds is carried out in two steps. In the first step, the 1,2-dibromoethane reacts with sodium sulfite to produce ethyl dibromosulfate. In the second step, this compound reacts with hydrofluoric acid to produce 1,2-dibromoethane-1-sulfonyl fluoride.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Bromo-8-methoxyquinoline is an organic compound with the chemical formula C8H6BrN2O. It is a colorless solid that is soluble in organic solvents. The molecule consists of a six-membered ring with two bromine atoms and one methoxy group attached to each ring carbon. It can be synthesized by reacting 4-bromophenol with formaldehyde followed by heating the reaction mixture to produce 4-(4,5-dihydroxyphenyl)-1,3,2-oxazinane. This product can be chlorinated to produce monochloro or brominated to produce dibromo derivatives. The infrared spectrum of 4-bromo-8-methoxyquinoline shows peaks at 1650 cm−1 (C=O), 1510 cm−1 (C=N) and 1340 cm−1 (C=Cl). The yield for this

6-Bromo-8-methoxyquinoline is a quinoline that has shown anticancer activity. The anticancer effect of this compound is due to its ability to inhibit the synthesis of DNA, RNA, and protein in tumor cells. This drug also has a cytotoxic effect on lymphocytes. 6-Bromo-8-methoxyquinoline is a derivative of methoxyquinoline, which was used as an antiparasitic agent for the treatment of schistosomiasis.

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-1-(1H-indol-5-yl)ethanone is an aminated product that can be synthesized by the reaction of nitromethane and aluminium chloride. This product is a side-chain condensation product of indoline and chloroacetyl chloride. The product yields are about 68%.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Nitroquinolin-2-ol is a molecule that has been developed to modulate the activity of glutamate receptors. It is synthesized by reacting an ethyl group with hydrochloric acid in the presence of a borohydride reducing agent, such as sodium borohydride. 3-Nitroquinolin-2-ol has been shown to be effective against cancer cells and can inhibit the growth of bacteria by binding to toll-like receptor proteins. The synthesis of this molecule is done under inorganic acid conditions, which give it a polymer conjugate property.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-(4-Methylcyclohexyl)acetamide is a cation that can be prepared by the reaction of phenylmagnesium bromide with acetamide. This compound has been shown to have a stereogenic center and reacts as an ether. It crystallizes in the monoclinic system, which is also known as crystal class 2/m. The radical formed from this cation has been shown to be stable at low temperatures and in the presence of perchlorates. N-(4-Methylcyclohexyl)acetamide has been found to react with x-rays, causing a change in its spectrum. It has also been shown to form a perchlorate by reacting with chlorine gas.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

5-(Aminomethyl)quinolin-8-ol dihydrochloride is a molecule that has been shown to inhibit the absorption of dietary fats. It is thought to be a potential weight-loss drug, as it reduces the number of fat cells in mice. The molecule is synthesized by reacting an amine with 5-amino-2,3-dihydroquinoline and quinolinic acid in a Langmuir isotherm. The molecule then undergoes hydrolysis, resulting in 5-(aminomethyl)quinolin-8-ol. This compound was shown to reduce weight gain in mice fed high fat diets by up to 30%. The functional theory behind this effect is that the amino group on the molecule reacts with fatty acids, preventing their absorption into the bloodstream. This process has been observed using electron microscopy and elemental analysis techniques.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Ethyl-N-(propan-2-yl)aniline (4EA) is an organic compound that is used as a coupling agent in the production of polyurethane. 4EA reacts with styrene monomer to produce a polymer that can be crosslinked with diisocyanate. The reactivity of 4EA depends on the nature of substituents, the type of solvent, and the temperature. It has been shown that 4EA is more reactive in water than in alcohols and yields a higher degree of substitution when reacted with styrene in supercritical CO2. 4EA is an intermediate for the synthesis of other chemicals such as phenols and acetophenone.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(1H-Benzo[D]imidazol-1-yl)-N-methylacetamide is a water soluble compound that is used to enhance the data transfer rate in multimedia and computer networks. It is also an adsorbent that can be used to remove sodium ions from deionized water. 2-(1H-Benzo[D]imidazol-1-yl)-N-methylacetamide has been used as a reagent for the detection of amyloid plaques in human brains by immunohistochemical staining techniques. This reagent has been shown to bind selectively with the amyloid beta protein and can be used for the diagnosis of Alzheimer's disease.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Trans-4-Cyclohexyl-L-proline is an enolate that is used as a pharmaceutical intermediate. It has been shown to be effective in the synthesis of fosinopril sodium, a drug used for the treatment of hypertension and heart failure. Trans-4-Cyclohexyl-L-proline also has shown potential use as an antimicrobial agent. It can act as a nucleophilic agent, reacting with chloride ions to form an alkylating agent. The chlorinated product can undergo hydrolysis by hydrochloric acid to yield c1-4 alkyl chloride and hydrogen chloride.</p>

<p>Chroman-6-carboxylic acid is a hydroxamic acid that is used in the production of carboxylate emulsions. It is an active substance that has been shown to inhibit the growth of bacteria and fungi. Chroman-6-carboxylic acid has also been shown to be a strong oxidizing agent, which can generate hydrogen peroxide in alkaline media. This agent also has functional groups such as carboxylate, chloride, and carboxylic acid.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>5-Acetamido-2-methylbenzoic acid is a linker that is used to attach ubiquitin to other proteins as a covalent inhibitor. It has been shown to inhibit the HIV-1 reverse transcriptase, which is an enzyme in the viral replication process. 5-Acetamido-2-methylbenzoic acid is also able to form a covalent bond with peptidomimetic warheads, which are compounds that mimic viral proteins and inhibit the activity of host immune response enzymes. This compound has been shown to be reactive with polymerases, such as RNA polymerase and DNA polymerase, inhibiting their activity.</p>

Versatile small molecule scaffold

2-(2-Acetamidophenyl)acetic acid is a product that has been shown to have immunosuppressive and anti-inflammatory effects. It inhibits the production of proinflammatory cytokines, such as tumor necrosis factor (TNF), by blocking the lipoxygenase pathway. 2-(2-Acetamidophenyl)acetic acid also inhibits the expression of proinflammatory genes, such as IL-1β and IL-6, in human cells. 2-(2-Acetamidophenyl)acetic acid is used for the treatment of autoimmune diseases, eye disorders, and inflammatory diseases.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(3-Methyl-2,4,5-trioxoimidazolidin-1-yl)acetic acid is a potent activator of the GABAA receptor and an inhibitor of glutamate release. It has been observed to increase GABAergic neurotransmission in the brain and to inhibit protein interactions. In addition, 2-(3-Methyl-2,4,5-trioxoimidazolidin-1-yl)acetic acid can be used as a research tool for studying ion channels and peptides.