Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Ethyl-1H-pyrrole-2-carbaldehyde is an anticancer drug that belongs to the group of natural products. This compound has been shown to be a potent inhibitor of Jak3, which is a protein tyrosine kinase receptor. It prevents the activation of the JAK3 signaling pathway and inhibits cell growth in cultured cells. 5-Ethyl-1H-pyrrole-2-carbaldehyde also has anti-cancer properties that are due to its ability to inhibit DNA synthesis and cause lysosomal damage. 5-Ethyl-1H-pyrrole-2-carbaldehyde can be used as a potential treatment for cancer, with possible advances in synthetic chemistry and biological mechanisms.

Versatile small molecule scaffold

2-(1H-Indol-2-yl)ethanol is a homologous compound that belongs to the group of cinnamic compounds. It is used in the industrial preparation of 2,4-dihydroxybenzoic acid and 3,4-dihydroxybenzoic acid, which are used as chiral auxiliaries in the manufacturing of pharmaceuticals. 2-(1H-Indol-2-yl)ethanol has been shown to inhibit rhizobiaceae and other soil bacteria. 2-(1H-indol-2-yl)ethanol also inhibits aging through its ability to induce apoptosis in human fibroblast cells.

Versatile small molecule scaffold

3-Acetamido-4-picoline (3AP) is a fatty acid that has been used in the treatment of autoimmune diseases. It is also a potent activator of AMPK, which is an enzyme that regulates cellular metabolism and energy homeostasis. 3AP has been shown to have antibacterial activity against a wide range of bacteria, including Mycoplasma and endophytic fungi. 3AP also inhibits leukotriene receptor antagonists, which are important for the inflammatory response. 3AP may be used as a diagnostic agent to measure body fat mass and body mass index in humans. The type strain for this compound is ATCC 21797.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Benzyloxy)-2-hydroxybenzaldehyde is a functional compound that has various tautomeric forms. It can be found in the mesomorphic form at low temperatures and in the imine form at higher temperatures. It is also active as an anti-inflammatory agent, inhibiting cyclooxygenase and lipoxygenase enzymes. 4-(Benzyloxy)-2-hydroxybenzaldehyde has been shown to have a protective effect on cells from Alzheimer's disease and other neurodegenerative diseases by preventing the aggregation of beta-amyloid proteins that are implicated in these diseases.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Dicyclohexylacetic acid is an organic compound that is used as a reagent to measure the binding constants of proteins. It has a hydrophobic effect, which may be due to its particle size, and it has been shown to have antioxidant properties. Dicyclohexylacetic acid is also used in the production of chemical structures, such as hydrogen bond and carboxylate. It can be used in the treatment of autoimmune diseases by inhibiting serine protease activity and radiation therapy. Naphthenic acids are found in crude oil, and FT-IR spectroscopy can be used to detect these acids.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Nitrophenethyl alcohol is a trifluoroacetic acid derivative that has been shown to have antimicrobial activity against multidrug resistant Gram-negative bacteria. 3NPHA is an electrophilic compound that reacts with the nucleophilic amino acids in proteins, causing the protein to be irreversibly denatured. 3NPHA has been shown to inhibit the growth of bacteria by binding to ribosomal RNA, preventing protein synthesis and cell division. The specificities of this drug are not yet well understood, but it has been found to bind to both isomers of the nucleotide erythromycin A. 3-Nitrophenethyl alcohol may be used as a catalyst for reactions involving isoxazoles, which are compounds that can act as anticancer agents.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(Iodomethyl)cyclopentane is a potent cytotoxic agent that inhibits the proliferation of a wide range of cells. It binds to the DNA of proliferating cells and causes cross-linking and strand breakage, which leads to cell death. This compound also has anti-inflammatory properties and can be used in hyperproliferative diseases such as cancer, as well as infectious diseases such as tuberculosis. (Iodomethyl)cyclopentane is not available for sale in its pure form, but rather in a salt form.

5-Chloro-2-methylbenzylamine is a chemical compound that has been shown to be an effective ozone depleter. It has also been used to study the relationship between chemical structure and reactivity, as well as in regression analysis. The ionic, nucleophilic, and electron properties of 5-Chloro-2-methylbenzylamine have been studied by looking at its affinity for different metal ions. This molecule can be used in organic pollutant remediation because of its ability to catalyze the regeneration of ozonide when it is oxidized by oxygen in water. This reaction is reversible, so 5-Chloro-2-methylbenzylamine can be regenerated from the ozonide product.

Versatile small molecule scaffold

(R)-2-(1-Hydroxyethyl)pyridine is an enantiopure compound that is used as a catalyst in the production of alcohols, carbinols and hydrocarbons. It has been shown to be a high yield preparative catalyst for catalytic asymmetric reactions. The enzyme alcohol dehydrogenase catalyses the oxidation of (R)-2-(1-hydroxyethyl)pyridine to form an intermediate that can then be oxidized by the enzyme carbinol dehydrogenase, which produces carbinols. This product has also been found to act as a vasodilator and nonselective inhibitor of phosphodiesterases 3 and 4.

Versatile small molecule scaffold

5-Iso-butyl-5-methylhydantoin is an organic compound that contains a sulphonic acid group. It has the chemical formula of CH3C(O)NHCH2SO3H. 5-Iso-butyl-5-methylhydantoin is soluble in water and has a pH between 1 and 4. It can be used as a solvent for substances with high solubility, such as additives, solutions, and inorganic materials. The flow properties of 5-isobutyl-5-methylhydantoin are dependent on the binder or carbon atoms present.

Versatile small molecule scaffold

5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid (DMPC) is a reactive compound that has been shown to be optically active. DMPC is found in plants and is used as an antiseptic and germicide. It is also used as an ingredient in horticultural products. The chloro group on the DMPC molecule can react with other compounds, such as chloride ions, to form a chlorinated derivative which exhibits increased antibacterial activity. This increased antibacterial activity may be due to the fact that the chlorine atom in DMPC reacts with bacterial cell membranes, making them more permeable and leading to cell death.

Versatile small molecule scaffold