Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(4-Nitro-pyrazol-1-yl)-ethanol is a cyclic anion that has been shown to be damaging to DNA. It has been studied by the kinetic methods of anion exchange chromatography and solvent extraction. 2-(4-Nitro-pyrazol-1-yl)-ethanol was found to be a weak base, with a pKb value of 10.2. The compound reacts with glutathione to form 2-(4-nitro-pyrazol-1-yl)-ethanesulfonic acid, which is in equilibrium with the corresponding alcohol. This reaction can be measured by monitoring the changes in absorbance at 260 nm and 280 nm. The nitro group on 2-(4-nitro-pyrazol-1-yl)-ethanol shifts the potentials of methylene blue and methyl green toward more positive values, making them more sensitive to this type of damage.

Versatile small molecule scaffold

Versatile small molecule scaffold

N-Cyclopentylsulfamoyl chloride is a diuretic drug that is used in veterinary medicine. It has been shown to increase fertility in animals. N-Cyclopentylsulfamoyl chloride also has aliphatic, sulfamates, and sulfamoyl chloride properties.

(R)-1-(p-tolyl)ethan-1-ol is a chiral alcohol that can be synthesized through the reduction of p-chlorobenzaldehyde with sodium borohydride. It has been shown to have an inhibitory effect on bacterial growth, but not mammalian cells. The hydroxyl group on the (R)-1-(p-tolyl)ethan-1-ol molecule interacts with the cell membrane, which increases its permeability and thus allows for a greater substrate concentration. This reaction is stereoselective, so only one enantiomer will react with the enzyme. Preparative methods are employed to separate this compound from other enantiomers and purify it for use in biological experiments.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(1-Piperidinyl)benzoic acid is an intramolecular, terminal oxidant. It activates a variety of bonds including C–H, C–X, N–H, and O–H bonds. This compound is also an efficient oxidant with high reactivity and selectivity. 2-(1-Piperidinyl)benzoic acid has been shown to be an aerobic oxidant that can activate a variety of bonds with high efficiency. In addition, this molecule has shown the ability to efficiently convert alcohols and esters into carbonyl compounds under dehydrogenative conditions.

1-(Pyrrolidin-1-yl)prop-2-en-1-one is a monomeric, hydrating, and inhibiting molecule. It has been shown to inhibit the homopolymerization of polydimethylsiloxane (PDMS) by competing with the PDMS for the active site on the enzyme DNA polymerase. 1-(Pyrrolidin-1-yl)prop-2-en-1-one also inhibits copolymerization of PDMS with methyl methacrylate (MMA). The inhibition constant for this molecule is 4.56 × 10 M, which corresponds to a half maximal inhibitory concentration of 2.14 × 10 M. The kinetic constants for 1-(pyrrolidin-1-yl)prop-2-en-1 one are k = 0.063/min and k = 0.0016/min, respectively.

3-Hydroxy-2-nitrobenzaldehyde (3HNB) is a potent inhibitor of glucose uptake. This compound inhibits the activity of glucose transporter 2 (GLUT2), which is responsible for transporting glucose across the cell membrane into the cell. In addition, 3HNB has been shown to inhibit the activity of other glucose transporters and enzymes involved in glycolysis and gluconeogenesis, leading to reduced rates of glucose production and increased rates of glucose consumption. The hypoglycemic effect of 3HNB is due to its inhibition of key enzymes involved in carbohydrate metabolism, as well as its ability to block GLUT2 from transporting glucose into cells. It has also been shown that 3HNB can cause weight loss by decreasing appetite and increasing energy expenditure in mice fed high fat diets.

Versatile small molecule scaffold

Versatile small molecule scaffold