Building Blocks

<p>3-Chloro-N-methyl-2-nitroaniline is an antibiotic that belongs to the group of quinolone antibiotics. It has a broad spectrum against Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. 3-Chloro-N-methyl-2-nitroaniline binds to bacterial DNA gyrase and topoisomerase IV, as well as human DNA gyrase and topoisomerase II, inhibiting their activity. This leads to cell death by interfering with the production of proteins vital for cell division. The optimal parameters for this drug have been found using isothermal titration calorimetry on the enzyme gyrase in the presence of different concentrations of 3CMA. Pharmacological targets for this drug include DNA gyrase and topoisomerase IV.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5F-203 is a new chemical entity that has been shown to inhibit the function of cytochrome P450 1A1 (CYP1A1), which is involved in the metabolism of many substances, including drugs. It also inhibits the function of mitochondrial membrane potential and promotes reactive oxygen species production. These effects are thought to be responsible for its anticancer activity. 5F-203 has been studied in cancer cells and breast cancer cells with low potency. The biological properties of 5F-203 have not been determined yet.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2H-Benzo[b][1,4]oxathiepin-3(4H)-one is a hydrazine that can be used as an intermediate in chemical synthesis. It has the chemical properties of a carbonyl group, which includes an acyclic structure and α-amino acid substituents. 2H-Benzo[b][1,4]oxathiepin-3(4H)-one is an interaction compound that has been shown to have a cyclic structure with carboxylic acid substituents. The chemical properties of 2H-benzo[b][1,4]oxathiepin-3(4H)-one are similar to hydroxylamine.END&gt;&gt;</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Methylphenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5-one is a cross linking agent that is used in the production of polyurethanes. It is derived from 2,2'-oxydiethanol and can be used as a polymerization catalyst for polyurethane resins. 1-(2-Methylphenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5 -one has been shown to have antibacterial properties against gram positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae. The antibacterial activity was attributed to its ability to form covalent bonds with carboxylic acid groups on the bacterial cell wall.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Bicyclo[4.1.0]heptan-7-ylmethanol is a hydride inhibitor of lactate dehydrogenase, which is an enzyme that catalyzes the conversion of pyruvate to lactate in the liver. Bicyclo[4.1.0]heptan-7-ylmethanol has inhibitory properties against aldehyde dehydrogenase and alcohol dehydrogenase, which are enzymes involved in the metabolism of aldehydes and alcohols respectively. This substance also inhibits mitochondrial monoamine oxidase (MAO), which is an enzyme that breaks down neurotransmitters such as dopamine, norepinephrine, and serotonin. Bicyclo[4.1.0]heptan-7-ylmethanol can be used to inhibit the function of MAO in order to increase levels of these neurotransmitters in the brain, which may be helpful for conditions like depression or Parkinson</p>

<p>1-Benzothiophene-6-carboxylic acid is a nicotinic acetylcholine receptor agonist that has been shown to have high oral bioavailability and efficacy in vivo. It binds to the α7 nicotinic acetylcholine receptor and activates the receptor, leading to increased neurotransmitter release. 1-Benzothiophene-6-carboxylic acid has been shown to be effective in vivo in models of neuropathic pain and Parkinson's disease. This drug also has a low affinity for other receptors, such as muscarinic acetylcholine receptors, which reduces the chance of adverse effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-6(methylamino)purine is a potent inhibitor of xanthine oxidase. It is structurally similar to allopurinol, an inhibitor of xanthine oxidase that is used to treat gout. 2-Chloro-6(methylamino)purine inhibits the enzyme by forming a noncompetitive complex with it, which prevents the production of uric acid. This compound has been shown to be effective at inhibiting xanthine oxidase in humans and has been used as a lead compound for the development of new inhibitors of this enzyme.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>