Building Blocks

Versatile small molecule scaffold

<p>Dimethylaminobutyronitrile (DMAbN) is a quaternary ammonium compound that is used in the synthesis of pharmaceuticals and agrochemicals. It is an inhibitor of aggrecan, which is a glycoprotein found in cartilage. DMAbN has been shown to inhibit the expression of receptors in osteoarthritic joints.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,2,3,4-Tetrahydro-1,5-naphthyridine is a mitotic inhibitor that binds to the protein cyclin. It is present in two forms: pyrrolidino and aryloxy. The pyrrolidino form is an anticancer agent that inhibits mitosis by binding to the active site of the enzyme DNA polymerase. The second form has been shown to have antitumor properties and inhibit protein synthesis in tumor cells. Tetrahydro-1,5-naphthyridine also has an anticancer effect on leukemia cells and other types of cancer cells. It has been shown to inhibit the growth of tumor cells by inhibiting protein synthesis through inhibition of enzymes such as cyclopentyl and protein inhibitor. This drug also has a tautomeric form that is an inhibitor of cyclohexane ring formation during metabolism in animals. Tetrahydro-1,5-naph</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Pyridin-2-yl)butanoic acid hydrochloride (4-APB) is a potent inhibitor of ion channels, including the nicotinic acetylcholine receptor and the NMDA receptor. 4-APB is a ligand for the GABA receptors and benzodiazepine sites on GABA A receptors. It has been shown to inhibit the activity of protein kinase C and protein tyrosine kinase, which are enzymes that regulate cell growth. 4-APB has also been shown to inhibit the production of tumor necrosis factor-α (TNF-α) by inhibiting the activation of NFκβ in mouse macrophages.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>3-Bromoimidazo[1,5-a]pyridine is a chemical compound that is used in the production of organic semiconductors. It has an emission wavelength of 550 nm and a quantum yield of 0.2%. 3-Bromoimidazo[1,5-a]pyridine can be produced by reacting benzene with bromine to produce the product. The reaction has a yield of about 85% as measured by weight.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>GSK 205 is a histamine receptor agonist that has been shown to have analgesic properties in animal models of pain. It binds to the TRPV4 ion channel and activates it, which results in an increase in the intracellular concentration of cations and an influx of calcium. This response has been shown to be mediated by calmodulin binding and GSK 205 also stimulates pancreatic enzyme secretion by activating the cytosolic Ca2+ response element-binding protein (CREB) pathway. The CREB pathway is involved in cell proliferation and differentiation, as well as memory formation. GSK 205 has been shown to have no adverse effects on skin cells when used at physiological levels.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Methyl 2-(dimethylamino)-6-methylpyrimidine-4-carboxylate (MDMP) is a natural compound that has been shown to have biological properties. It has a locomotor activity in mice and inhibits the growth of methicillin-resistant Staphylococcus aureus and Mycobacterium tuberculosis. MDMP is an inhibitor molecule that blocks the enzyme DNA polymerase, thereby inhibiting DNA synthesis. This drug also inhibits the production of phosphatidylcholine, which is important for maintaining cell membrane integrity.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Morpholinoethyl isothiocyanate is a synthetic chemopreventive agent that has been shown to be an antioxidant and to induce apoptosis of cancer cells in vitro. It inhibits the growth of liver cancer cells by inhibiting the transcription of oncogenes, such as c-myc and c-jun, and also by inhibiting the activity of other enzymes, such as glutathione S-transferase. 2-Morpholinoethyl isothiocyanate also induces apoptosis in fibroblasts by activating transcription factors, such as NF-κB, which regulate the expression of proapoptotic genes.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Puerarin is a natural compound that is found in the roots of the plant Pueraria lobata. It has been shown to inhibit the binding of dopamine receptor agonists to their receptors, which may be due to its structural similarity to dopamine. Puerarin also inhibits the activity of an enzyme called tyrosine hydroxylase, which converts tyrosine into l-dopa and is a key enzyme in the synthesis of neurotransmitters such as dopamine and norepinephrine. Puerarin has been shown to have anti-inflammatory effects in tissue culture experiments, and it may possess potential for treating autoimmune diseases due to its ability to inhibit inflammatory responses.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

2-(4-Methoxy-3-nitrophenyl)acetic acid is a linker used in peptide synthesis. It reacts with benzylic alcohols to form stable, cleavable linkages. 2-(4-Methoxy-3-nitrophenyl)acetic acid preferentially reacts with phenylacetic acid and deprotects the benzyl group from a peptide. This product is stable at room temperature and can be used in solid phase chemistry, such as peptide synthesis.

<p>Versatile small molecule scaffold</p>