Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>The tert-butyl N-[1-(hydrazinecarbonyl)-2-hydroxyethyl]carbamate (TBHEC) is a molecule of tert-butyl with a carbonyl group. The carbonyl groups are mediated by hydrogen bonds. TBHEC has two-dimensional structure and is sandwiched between the carbonyl groups, forming a dihedral angle. One of the carbonyl groups has hydroxy group which forms a hydrogen bond with one of the hydroxy group on the other carbonyl group. The other three carbonyls of TBHEC form an equilateral triangle and are not involved in bonding.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 1-acetylcyclopropane-1-carboxylate is a synthetic quinolone antibacterial agent. It has been shown to inhibit gram-positive bacteria, such as Streptococcus pyogenes, Staphylococcus aureus, and Enterococcus faecalis. The compound also inhibits the growth of other gram-positive pathogens, such as Propionibacterium acnes and Corynebacterium diphtheriae. Ethyl 1-acetylcyclopropane-1-carboxylate binds to the enzyme DNA gyrase, which is required for bacterial replication and transcription. This binding prevents DNA from unwinding during replication and transcription, which leads to cell death by inhibiting protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,3,4,6-Tetrafluorobenzoic acid is a synthetic chemical that is used as a growth regulator in plants. It is often found in the form of its sodium salt. 2,3,4,6-Tetrafluorobenzoic acid regulates plant growth by inhibiting the production of auxins and other hormones. This compound has been shown to inhibit the synthesis of chlorophyll and disrupt plant metabolism at high concentrations. 2,3,4,6-Tetrafluorobenzoic acid also has been shown to be an effective insecticide when applied to plants.</p>

<p>2-Hydroxy-4-methylquinoline-3-carboxylic acid (HMQC) is a chloride thionyl bioactive compound that interacts with the kidneys. HMQC has been extracted from plants and is also found in human urine. The efficiency of this method for extracting HMQC depends on the amount of organic solvents used and the temperature at which it is hydrolyzed, as well as its stability. HMQC can be extracted by carbon tetrachloride (CCl) or tetrachloride (Cl), which are alkaline hydrolysis solvents. HMQC is an efficient diuretic and has shown to be an effective treatment for acute renal failure.</p>

<p>2-N-Cyclopropylamino-4,6-dichloro triazine is a chlorinated triazine herbicide. It is used to control broadleaf weeds and grasses in rice fields. The toxic effects of 2-N-cyclopropylamino-4,6-dichloro triazine are related to its amination by ethanol in the presence of hydrochloric acid. This reaction takes place in the presence of water, yielding cyanuric chloride and hydrogen chloride gas. Cyanuric chloride reacts with water to form cyanuric acid and hydrogen chloride gas. Cyanuric acid is highly toxic because it inhibits the Krebs cycle in cells, which leads to cell death. The reaction time for this herbicide ranges from 8 hours to 24 hours depending on the temperature.</p>

<p>2-(Benzyloxy)-4-methoxybenzenecarbaldehyde (BMB) is an anticancer agent that has been shown to induce apoptosis in cancer cells. This compound reduces the mitochondrial membrane potential, which leads to the release of cytochrome c and loss of mitochondrial membrane potential. BMB also inhibits protein synthesis and has a strong inhibitory effect on cell proliferation. In addition, it has been shown to be effective against pancreatic cancer cells. This compound may be useful for the treatment of other cancers as well, such as breast, colon, and prostate cancer.</p>

6,6-Dimethylbicyclo[3.1.1]hept-2-ene is an α-pinene molecule that has been shown to have cytotoxic properties in mammalian cells and significant anticancer activity against pancreatic cancer cells. The molecular structure of 6,6-dimethylbicyclo[3.1.1]hept-2-ene includes a double bond between carbons 6 and 7, which is where the molecule gets its name from. This compound has been shown to be able to induce apoptosis in cancer cells by activating the CB2 receptor and inhibiting the activity of molecules called GPR55 and TRPV4. 6,6-Dimethylbicyclo[3.1.1]hept-2-ene also reacts with intramolecular hydrogen to form a bicyclic system with a double bond between carbons 1 and 2, which increases its cytotoxicity against cancer cells due to the

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Phenethylbenzaldehyde is a phenylaldehyde derivative that can be used as a reagent for the conversion of aldehydes to their corresponding hydroxylamines. It is also an important precursor in the synthesis of many heterocycles. 2-Phenethylbenzaldehyde can be used as an additive in perfumes and cosmetics because it has a pleasant odor and low toxicity. This substance is stable at room temperature, but decomposes at high temperatures. 2-Phenethylbenzaldehyde reacts with deuterium to produce carbenes, which are reactive intermediates that may react with other molecules to form new compounds. This compound reacts with light or ultraviolet light (UV) photons to form diazo, which may react with other molecules to form new compounds. The sensitivity of 2-phenethylbenzaldehyde is increased when it contains deuterium isotopes.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-4,5-dimethoxyaniline is an organic compound that is a member of the class of ethers. It can be used in a variety of chemical reactions such as benzoquinone synthesis, arylation, and chlorination. 2-Chloro-4,5-dimethoxyaniline is soluble in methanol, but insoluble in water. It decomposes when heated and can react with hydrogen chloride or chlorine to form hydrogen chloride gas or chlorine gas respectively.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Hydrazinylacetic acid hydrochloride is a nitro compound that is used as an intermediate in organic synthesis and as a pharmaceutical agent. This drug has antiviral activity, and has been shown to inhibit the replication of both influenza virus and human immunodeficiency virus. It also inhibits angiotensin-converting enzyme, which is involved in the regulation of blood pressure and blood volume. In addition, 2-hydrazinylacetic acid hydrochloride inhibits the production of hepatitis B virus surface antigen (HBsAg) in infected cells and inhibits the growth of cultured hepatoma cells. This drug also has anti-inflammatory properties and can be used to treat inflammatory diseases such as rheumatoid arthritis. 2-Hydrazinylacetic acid hydrochloride is absorbed by the skin when topically applied, but not through oral administration.</p>

<p>4-(3-Morpholinopropyl)-3-thiosemicarbazide is a thiadiazine compound that inhibits protein glycation and glycation. It has been shown to effectively inhibit glycation in vitro and vivo with the model system. 4-(3-Morpholinopropyl)-3-thiosemicarbazide has been shown to have anti-inflammatory properties, which may be due to its ability to block the formation of advanced glycated end products (AGEs) by blocking the reaction between glucose and proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(E)-Coniferol is a coniferyl alcohol that is found in plants. It is synthesized from the coniferyl alcohol and eugenol by oxidation of the double bond with hydrogen peroxide. (E)-Coniferol has been shown to have physiological effects. It also binds to ATP-binding cassette transporter proteins and can be used as a model system for polymer compositions. (E)-Coniferol has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.</p>

Methyl 2-methyl-4-oxopentanoate is a natural product that can be prepared by enzymatic hydrolysis of methyl 2-methyl-4-oxobutanoate. It has been shown to have anti-inflammatory activities, which may be due to its ability to inhibit lipase activity in the pancreas. Methyl 2-methyl-4-oxopentanoate is an α,α′-(1,2,3,6,-tetrahydropyridyl) ester with an enantiomeric excess of 100%. This compound also has been shown to interact with lipases at physiological concentrations and kinetic parameters are known for the interaction. Methyl 2-methyl-4-oxopentanoate is able to inhibit lipase activity when it binds reversibly in a noncompetitive manner.

<p>Sodium dipentylcarbamodithioate is an aliphatic hydrocarbon that is used as a coupling agent in organic synthesis. It has been known to react with molybdenum, forming a product that resembles the structure of fatty acids. Sodium dipentylcarbamodithioate also reacts with glycerin to form an ester. This reaction product is a viscosity modifier and corrosion inhibitor for petroleum products. The functional groups of this compound are dithiocarbamic, which are acidic and react with fatty acids to form salts.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-chloro-2-oxo-3-phenylpropanoate is a covalent analog of paclitaxel. It has been synthesized by the chemoenzymatic reaction of acetyl chloride, chloroacetic acid, and phenylacetaldehyde in the presence of thiosemicarbazide. The yield is 80%. The product has been shown to have similar biological activity as paclitaxel. The synthesis of methyl 3-chloro-2-oxo-3-phenylpropanoate is based on nature.</p>

<p>Versatile small molecule scaffold</p>

<p>N-Acetylprocainamide is a prodrug that is hydrolyzed in vivo to procainamide, its active form. Procainamide is used for the treatment of cardiac arrhythmias, but has been shown to have minimal toxicity. N-acetylprocainamide has been shown to be effective in experimental models and has minimal toxicity in long-term studies. This drug can be administered orally or intravenously and has been shown to have a low rate constant. The analytical method for this drug is chromatographic analysis.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-Nitroethenyl)furan is a phosphatase inhibitor that has been shown to be active against Leishmania, an intracellular parasite. This drug prevents the production of energy in the form of ATP by inhibiting the activity of phosphatases and thus disrupting cellular homeostasis. 2-(2-Nitroethenyl)furan binds to the enzyme with irreversible inhibition, which leads to clinical relevance in vitro and in vivo studies. The CD-1 mouse model has demonstrated that 2-(2-Nitroethenyl)furan inhibits bacterial growth with a prolonged half-life. In vitro assays have shown that this drug inhibits protein synthesis and is effective against resistant microorganisms.</p>

<p>N-Methyl-N-(2-pyrrolidin-1-ylethyl)amine is a selective, orally bioavailable κ-opioid receptor antagonist. It has been shown to have improved selectivity for the κ-opioid receptor over the μ- and δ-opioid receptors. NMPEA has a long duration of action, with pharmacokinetic profiles that are independent of dose. This drug is a lead compound for the treatment of pain and opioid dependence.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>This compound is a selective hydrogenation catalyst with a high degree of selectivity for the reduction of chlorinated aliphatic and aromatic compounds. The catalyst can be immobilized on different supports, such as palladium on alumina or carbon. It has been shown that the nature of the support has an effect on the catalytic activity and selectivity. This immobilized catalyst is more stable than unsupported catalysts and it can be used in batch processes.</p>

<p>Methyl 2-(4-methoxyphenyl)-2-oxoacetate is a chemical compound synthesized from the reaction of acetone, benzene, and phosphorous pentachloride. The product is an oily liquid that is soluble in ether and chloroform. It can be used as a reagent to synthesize phosphonates and phosphite esters. Methyl 2-(4-methoxyphenyl)-2-oxoacetate is also used to prepare tetronic acid by dehydration and grignard reaction with bromoanisole.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Benzyl-6-oxopiperidine-3-carboxylic acid is a diastereomeric, intramolecular, efficient, functionalized primary amine. It is synthesized from the reaction of cyclohexanone and benzaldehyde in the presence of a base. The amine group is subsequently converted to an acid chloride with thionyl chloride and then reacted with 1,2-diaminocyclohexane. The product can be used as a precursor for other compounds.</p>

<p>2-(5-Oxopyrrolidin-3-yl)acetic acid is a succinimide monomer that can be polymerized to form polymers. It is also an isomer of hexacyclic and bicyclic compounds, which are both isomers of dimethyl glutarimide. The polymerization of 2-(5-oxopyrrolidin-3-yl)acetic acid is carried out by reacting it with other monomers such as ethylene glycol or methyl methacrylate. The polymerization reaction results in the formation of long chains of molecules called polymers. This process can be carried out in a two step process, where 2-(5-oxopyrrolidin-3-yl)acetic acid first reacts with ethylene glycol to form the desired product and then proceeds to react with methyl methacrylate to produce the desired polymer.</p>

<p>Cycloheptanecarbonitrile is a homogeneous catalyst that acts as a stabilizer, coenzyme, and fatty acid. It has been shown to be an effective nutritional supplement for inflammatory bowel disease and autoimmune diseases. Cycloheptanecarbonitrile is also reactive with quinoline derivatives and aromatic hydrocarbons, which may lead to cancer. This product is used in medicines such as coenzyme q10, which aids in the production of energy.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)acetic acid is an analog of benzoic acid that has been found to be a potent inhibitor of the enzyme carboxylesterase. 2-(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)acetic acid is used in the synthesis of other compounds by esterification with methanol or benzoic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Sodium citrate is a DNA methyltransferase inhibitor. It blocks the transfer of methyl groups to the dna, thereby inhibiting the production of methylated dna and preventing apoptosis. Sodium citrate also inhibits the expression of pro-apoptotic protein and can induce significant cytotoxicity in vitro. This drug has been shown to cause histological changes in cells through inhibition of DNA methyltransferases in HL-60 cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-Bromophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole is an aryl boronic acid that can be synthesized by a Suzuki reaction with an alkyl halide and sodium carbonate. This compound is used as a reagent in organic synthesis for the production of various pharmaceuticals. The most common use of this chemical is for the synthesis of angiotensin II antagonists. 2-(2-Bromophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole has also been shown to be a selective antagonist of angiotensin II type 1 receptors.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Methylphenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5-one is a cross linking agent that is used in the production of polyurethanes. It is derived from 2,2'-oxydiethanol and can be used as a polymerization catalyst for polyurethane resins. 1-(2-Methylphenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5 -one has been shown to have antibacterial properties against gram positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae. The antibacterial activity was attributed to its ability to form covalent bonds with carboxylic acid groups on the bacterial cell wall.</p>

<p>Versatile small molecule scaffold</p>

<p>N-Methyl-2-nitropyridin-3-amine is a hydroalcoholic compound that can stabilize the cell membrane of C. parapsilosis, which has been shown to inhibit growth and cause life-threatening effects. The benzyl group on the nitrogen atom of this compound helps to maintain its stability in water, as well as conferring some conformational rigidity to the molecule. Nitro groups are found on the ring of this organic compound, which gives it an inhibitory effect against pyridine rings in other molecules. This organic compound has a nitro group, which can be analyzed by parameters such as IR spectroscopy and NMR spectroscopy.</p>

<p>4-Nonylphenyl acetate is a phenolic compound that belongs to the class of anhydrides. It is used as a catalyst for the synthesis of 4-nonylphenol, which is an important precursor for the production of polymers, resins, and synthetic fibers. 4-Nonylphenyl acetate can be synthesized by the reaction of phenols and anhydride in the presence of a catalyst such as copper chloride or zinc chloride. This reaction can be carried out in either organic solvents or water. The yields are increased when microwave irradiation is used instead of conventional heating methods.</p>

Versatile small molecule scaffold