Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester is an inhibitor of acetylcholinesterase. It is a white solid that can be synthesized in two steps from commercially available starting materials. Inhibition of this enzyme leads to the accumulation of acetylcholine, which causes increased stimulation of nicotinic and muscarinic receptors. This drug has been shown to have IC50 values that are similar to those of the reference inhibitor donepezil. 1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester also interacts with sulfonyl chlorides, butyrylcholinesterase, and other proteins in a manner similar to donepezil. The molecular docking studies suggest that this compound binds competitively with the active site of acetylcholinesterase.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(4-Nitrophenoxy)propionic acid is a promiscuous compound that can be used to synthesize other compounds. It reacts with hydrochloric acid, nitro groups, and phosphorus pentoxide to produce nitro compounds. 3-(4-Nitrophenoxy)propionic acid reacts with benzoylamine in the presence of a cocatalyst to form alkoxycarbonyl products. The cocatalyst is typically a metal such as zinc or magnesium. 3-(4-Nitrophenoxy)propionic acid is also used as an agrochemical for controlling influenza virus and Influenzae bacteria.
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Versatile small molecule scaffold

2-Chloro-9H-carbazole (2CzC) is a heterocyclic compound that belongs to the group of carbazoles. It can be used as medicine and has been shown to be a good control experiment for other carbazoles. The nucleophilicity of 2CzC is affected by the functional groups present in the molecule, and it has been shown to react with anions such as Cl-, Br-, or I-. This heterocycle also has two resonance forms, which are generated by the electron delocalization in the ring system. The gas phase kinetics of 2CzC have been found to follow an Arrhenius relationship, with k = 3.6x10^3 M^-1 s^-1 at 298 K. Yields for this compound have been found to be high, with 90% yield when synthesized from chloroacetone and phenylmagnesium bromide.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methyl-2-phenylmorpholine is an industrial chemical that has a c1-c4 alkyl group. It can be used in the production of antidepressants, such as Tofranil, and other drugs. 2-Methyl-2-phenylmorpholine is also used in the industrial production of polymers.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Propylpyrazole is a non-classical inhibitor of aldehyde oxidase that has been shown to have an inhibitory effect on pentane. 1-Propylpyrazole has peroxidase-like activity, which means it can bind to lipid hydroperoxides in the presence of hydrogen peroxide or peroxidase. It has also been shown to be an effective inhibitor of dehydrogenase, which is an enzyme that catalyzes the oxidation of aldehydes and ketones to carboxylic acids. This drug is not active against classical aldehyde oxidases such as alcohol dehydrogenase, but it does inhibit polyunsaturated fatty acid synthesis by binding with cytochrome P450 enzymes.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

JMS-17-2 is a small molecule that was shown to have a potent and selective inhibitory effect on the production of chemokines in cancer cells. It blocks the interaction between CXCL12 and its receptor, CXCR4. This interaction is important for normal bone tissue development and function, as well as for chemotaxis and metastasis of cancer cells. JMS-17-2 has been shown to prevent tumor growth in animal models by inhibiting angiogenesis, or the formation of new blood vessels to supply nutrients to tumors. The drug also inhibits tumor growth by decreasing the number of primary tumors, reducing bone lesions, and inhibiting the progression of pancreatic cancer. Clinical trials are currently being conducted to assess the efficacy of JMS-17-2 in humans with advanced solid tumors.

Versatile small molecule scaffold

Please enquire for more information about Boc-4-(4-fluorophenyl)-piperidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methylbenzene-1,3-dicarbaldehyde is a divalent hydrocarbon that has an oxidation catalyst. This compound is used as an intermediate in the production of drugs and pharmaceuticals. It has been shown to have cardiovascular disorders, such as vasodilatation and hypotension. The mechanism of action is not fully understood but may be related to its ability to act as a nitrovasodilator by increasing nitric oxide (NO) release. 2-Methylbenzene-1,3-dicarbaldehyde also produces psychotic disorders when long term exposure occurs. This compound has been shown to have neurotoxic effects in animal models with long term exposure.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4-Dibromo-6-nitroaniline is a nitro compound that has been used in the production of dyes. It is also used as a component in the synthesis of other organic compounds. 2,4-Dibromo-6-nitroaniline can be produced by electrolysis of an acid solution containing radical cations and benzene. The radical cations are formed by proton transfer from the acid to the benzene, followed by electron transfer from benzene to the electrode. This process results in the formation of nitro groups on the benzene ring, which undergoes oxidation to form 2,4-dibromo-6-nitroaniline. The cyclic voltammetry shows that this process occurs via two pathways: one with a fast rate and one with a slow rate. The mechanism for this reaction is not yet known.

2-Phenyl-1,3,4-oxadiazole is a 2-phenyloxazole with an oxygen atom at the 1 position. It is a white crystalline solid that is soluble in water and has antibacterial properties. This chemical can be used as a catalyst for the synthesis of organic compounds. 2-Phenyl-1,3,4-oxadiazole reacts with nitro groups to form oxime derivatives and has been shown to inhibit the growth of fungi such as Candida albicans and Aspergillus niger. 2-Phenyl-1,3,4-oxadiazole can also be used as an antifungal agent against Trichophyton rubrum.
2-Phenyl-1,3,4-oxadiazole may be synthesized by reacting phenol with acetone in the presence of nitric acid or sulfuric acid. The structural formula for this compound is

1-Hydroxycyclopentane-1-carbonitrile is a monomer that is hydrolyzed to form benzoin and cyanohydrins. It can be used in the production of scifinder as a monomer or dimerizer.

Versatile small molecule scaffold

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.

3-Hydroxy-5-methylpyridine (3HMP) is a chemical substance that has been classified as an amine. It is a product of the metabolism of purines, which are nitrogenous bases found in DNA and RNA. 3HMP is produced by aerogenic bacteria (such as Enterobacter), and can be used to estimate the number of these bacteria present in water samples. 3HMP has been shown to have antiviral properties against influenza virus, and can be used as a biomarker for the presence of other viruses in animals. 3HMP also has mineralization properties, which have been studied extensively, particularly with regards to pancreatic disease.

Please enquire for more information about 4,5-Dihydro-1H-imidazol-2-amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

4,5-Dihydroxy-2,3-pentanedione is a carbonyl compound that is the product of the oxidation of ascorbic acid. It is used in wastewater treatment and has antimicrobial properties against infectious diseases. This compound has been shown to inhibit protein synthesis by binding to the ribosome and preventing the formation of peptide bonds between amino acids. 4,5-Dihydroxy-2,3-pentanedione has also been shown to bind to plasma proteins, which may be due to its acyl chain structure. 4,5-Dihydroxy-2,3-pentanedione can be synthesized in a catalytic mechanism that involves dehydroascorbic acid and molecular oxygen.

Piperyline is an alkanoic acid that has shown to be effective against skin cancer. It also has antimicrobial properties, which may be due to its ability to bind metal ions and form polymeric compounds. Piperyline inhibits microbial growth by inhibiting the synthesis of proteins and nucleic acids. The antimicrobial activity is related to its cationic polymerization with hydroxyl groups, which forms a structure that can inhibit microbial enzymes and disrupt microbial cell membranes. This compound also interacts with the skin's natural lipids, making it difficult for microorganisms to attach and grow on the skin. Piperyline is synthesized in organic chemistry laboratories as an amide precursor of other pharmaceuticals such as penicillin.