Building Blocks

<p>6,7-dimethoxyquinoline is a palladium-catalyzed coupling agent that has been shown to inhibit the growth of cells by blocking epidermal growth factor receptor. It has been shown to be effective in inhibiting restenosis and angioplasty in animal models. 6,7-Dimethoxyquinoline also has an innovative mechanism of action for cancer treatment as it inhibits the activation of certain signal transduction molecules. It also acts as a potent inhibitor for chloride channels and other ion channels, which may lead to its use as a powerful antihypertensive agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 5-aminothiophene-2-carboxylate is a hydrazine derivative that can be synthesized in two steps from ethyl 2-chloroacetate, ethyl chloroformate and sodium hydroxide. It has been shown to react with the trimethylsilyl chloride and trifluoroacetic anhydride in the presence of trifluoroacetic acid to form the corresponding 4-hydroxycoumarin derivative. The regioselective synthesis of ethyl 5-aminothiophene-2-carboxylate is achieved by using x-ray crystallography to identify the most reactive positions on the molecule for nucleophilic attack. This compound is efficient for generating 4-hydroxycoumarin derivatives, which are used as pharmaceuticals or as precursors for organic synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-(Hydroxymethyl)imidazolidine-2,4-dione (HMI) is a synthetic compound that has been shown to be effective for the treatment of tuberculosis. HMI is an analog of d-serine and is immobilized on activated carbon to produce filtration media. It was found to be more efficient than other immobilization methods in terms of yield, operational time, and filtration capacity. The affinity and chiral properties of HMI make it a good candidate for use as a drug delivery system.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Boc-2-hydroxy-2-phenylethylamine is a chemical that inhibits the reuptake of serotonin, which is a monoamine neurotransmitter. It is classified as a reuptake inhibitor. N-Boc-2-hydroxy-2-phenylethylamine competitively binds to the transporter that removes serotonin from the synapse, which leads to increased concentrations of serotonin in the synapse. This drug has shown efficacy in treating depression and could be used as an antidepressant.</p>

<p>Ethyl 3-oxododecanoate is a molecule that was synthesized by the bioassay-guided synthesis of flavonoids. It has antimicrobial activity against Pseudomonas aeruginosa and can be used for inhibiting bacterial growth in culture supernatant. Ethyl 3-oxododecanoate is an effective inhibitor of fatty acid biosynthesis, which makes it a potential therapeutic agent for infections caused by P. aeruginosa. This molecule has been modified to inhibit the production of lipopolysaccharide in P. aeruginosa, which inhibits its ability to stimulate immune responses and activate the complement system.</p>

<p>3-Ethynylpyridin-2-amine is a nucleophilic amine that has been synthesized as an intermediate for the synthesis of other compounds. It is a molecule that can be scavenged by electron deficiency and introduce water molecules to optimize biomolecular reactions. 3-Ethynylpyridin-2-amine is synthesized by reacting pyrrole with trifluoroacetic acid in the presence of ammonium hydroxide. The product can be isolated by removing the solvent and drying with magnesium sulfate. 3-Ethynylpyridin-2-amine has been shown to scavenge reactive oxygen species, such as hydrogen peroxide, which are produced during oxidative stress and have been implicated in many diseases, including cancer and cardiovascular disease.</p>

<p>Versatile small molecule scaffold</p>

<p>Pyrazine-2,3-dicarboxylic Acid Monoamide is a ligand that regulates the activity of metal ions. It has been shown to bind to alkali metal ions, such as potassium ion, and form coordination complexes with them. Pyrazine-2,3-dicarboxylic Acid Monoamide has also been shown to bind with other metals such as copper and zinc. The structural properties of these complexes have been determined by elemental analysis and X-ray crystallography. The coordination complexes have been found to have physicochemical properties similar to those of metal compounds.</p>

<p>4-Methyl-2-(4-methylbenzenesulfonamido)pentanoic acid (MBSA) is a synthetic histidine molecule that exhibits specificities for the pancreas. MBSA is converted to chloromethyl ketone when subjected to photooxidation. The mechanism of action of MBSA is postulated to be related to its chemical composition and kinetic properties, which are different from other histidines. Chemical analyses have shown that it has a tryptic pattern and an amino acid composition that is different from other histidines. It has been found that MBSA inactivates spermatozoa in vitro, which may be due to the presence of chloromethylketone on its molecular structure.</p>

<p>2-Hydroxy-3-isopropylbenzaldehyde is an aldehyde with the chemical formula C9H10O4. It is synthesized from 2,3-dihydroxybenzaldehyde by cyanosilylation and has an enantiomeric purity of 99%. The conformation of 2-hydroxy-3-isopropylbenzaldehyde can be determined by 2D NMR techniques as well as x-ray diffraction. The x-ray structure indicates that the molecule has a chair conformation, with a dihedral angle of 60°.<br>2-Hydroxy-3-isopropylbenzaldehyde can be used in the synthesis of heteroaromatic compounds, such as indole derivatives, through catalytic hydrogenation. This compound also reacts with sodium nitrite to form salicylaldehydes and alicyclic compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Hydroxy-4-[(5-methyl-1,2-oxazole-4-carbonyl)amino]benzoic acid is an ion channel inhibitor. It is a ligand that binds to the receptor site of voltage gated potassium channels and prevents the flow of ions through the channel. This inhibits the depolarization of nerve cells and reduces pain sensation. 2HMBAA has been used as a research tool for investigating protein interactions and has been shown to be a potent inhibitor of peptide binding to antibody sites on cell membranes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Amino-4-methoxynaphthalen HCl is an alkaloid that is synthesised from 1-Amino-4-(N,N-dimethylamino)naphthalene. It is a tetracyclic compound and it has been shown to be effective in the treatment of hypertension and other cardiovascular diseases.</p>

<p>Versatile small molecule scaffold</p>

<p>N/A</p>

<p>2-(2-Methoxyethoxy)benzaldehyde is a fluorescent organic compound that has binding properties to ethylene. It undergoes photophysical and chemosensors reactions, and can be used as a moiety in the synthesis of other compounds. 2-(2-Methoxyethoxy)benzaldehyde can be used as an enhancer for thiazole derivatives, which are metal ion chelators. The enhancement of thiazole derivatives is due to the presence of electron-donating methoxy groups on the benzaldehyde ring. 2-(2-Methoxyethoxy)benzaldehyde also has electrochemical properties that make it useful for the detection of metal ions such as copper ions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Benzoylpyrimidine is an anti-cancer drug that can be used as a monotherapy or in combination with other drugs. It has been shown to have significant activity against cancer cells and tuberculosis. This compound is synthesized by reacting aryl amine with benzoyl chloride in presence of potassium cyanide, followed by hydrolysis of the resulting nitrile. 5-Benzoylpyrimidine has also been shown to inhibit the growth of fungi, such as Candida albicans, Saccharomyces cerevisiae, and Aspergillus niger. The mechanism of action for this drug is not fully understood but may involve inhibition of protein synthesis at the ribosome level or inhibition of mitochondrial function.<br>5-Benzoylpyrimidine also inhibits the growth of bacteria such as Staphylococcus aureus, Enterobacter aerogenes and Klebsiella pneumoniae.</p>

<p>1,2-Dihydro-1,10-phenanthrolin-2-one is a ligand that binds to copper. It has been shown to be a functional group of the copper complex. The 1,2-dihydro-1,10-phenanthrolin-2-one molecule is able to bind to Alzheimer's disease amyloid plaques in vitro and may mediate their removal from the brain. This compound also interacts with metal ions such as copper oxide and phosphorus pentachloride. Mechanistic studies have been conducted using low energy electron diffraction device. Studies have shown that 1,2-dihydro-1,10 phenanthrolin 2 one binds to carboxylic acid groups on enzymes called esterases and inhibits their function by preventing them from binding phosphate groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Ethoxy-4-hydroxy-1,5-naphthyridine-3-carboxylic acid is a condensation product of pyrrolidino, propyl and hydroxylamine. It is an antifilarial agent that inhibits the growth of filaria and filariidae. This compound has shown efficacy in the treatment of cycloalkyl and piperidino nematodes, as well as in the elimination of malonate from the body. 6-Ethoxy-4-hydroxy-1,5-naphthyridine 3 carboxylic acid is also used to treat family members who have been infected with morpholinos.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-(4-Methylbenzenesulfonamido)-2-phenylacetic acid is a molecule with two nitrogen atoms in its structure. It contains one carboxylate group and the molecular weight of this compound is 178.22 g/mol. This molecule has a low molecular weight, which makes it a good candidate for use in organic synthesis. It can be produced by reacting ethylene with transition metal ions such as titanium tetrachloride or zirconium tetrachloride. 2-(4-Methylbenzenesulfonamido)-2-phenylacetic acid is resistant to both oxidation and reduction, making it an ideal candidate for use in organic synthesis. 2-(4-Methylbenzenesulfonamido)-2-phenylacetic acid diffracts light at a wavelength of 0.34 nm, making it useful for determining the size and shape of molecules that are crystallized from solution.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>