Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Chloro-1-ethyl-1H-pyrazole is an alkylhydrazine. It can be prepared by reacting 5-chloro-1,2-dihydro-3H-[1,2,4]triazole with ethyl chloride and sodium hydroxide in water. The yield of 5-chloro-1,2-dihydro-[3H]-pyrazole can be increased by using a dimethylhydrazine as the starting material. The reaction of 5-chloro-[3H]-pyrazole with benzoyl chloride in acetic acid yields the corresponding alkylhydrazone. The reaction of 5-(chloromethyl)-1,2-(dihydro)pyrazole with potassium bromide yields the corresponding dimethylhydrazine. Hydrazines and hydrazones are both nitrogen containing compounds that react with organic compounds in a similar way to form

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Thiazol-5-yl)acetic acid is an antimicrobial that is used as a fungicide. It has been shown to inhibit the growth of Fusarium and Curvularia. 2-(Thiazol-5-yl)acetic acid also has fungicidal activity against Refluxing, butanoic acid, and Oxysporum. This compound has been found to be effective against fungi in a number of different studies. 2-(Thiazol-5-yl)acetic acid inhibits the synthesis of ribosomes by inhibiting mRNA translation, leading to cell death by inhibition of protein synthesis.

Versatile small molecule scaffold

N-Methylquinolin-2-amine is a quinoline derivative that binds to the fatty acid ester of amides, which are found on the surface of cells. It has high specificity for hydroxy groups and is operational in aqueous solutions. N-Methylquinolin-2-amine has been shown to have activity against Alzheimer's disease by binding to the fatty acid ester of amide and blocking the function of ligands. The reaction time can be reduced by adding hydroxy group and alkyl group to the molecule. A molecular orbital diagram shows how this compound reacts with an amide substrate. This drug can be used as a diagnostic or postoperative treatment for Alzheimer's disease.

Versatile small molecule scaffold

2-bromo-1-cyclopentylethan-1-one is a racemic mixture of two enantiomers, 2-bromo-1-(2-methylpropyl)ethanone and 1-(2-methylpropyl)-2-(phenyl)ethanone. The compound has been shown to inhibit cell proliferation in vitro and has been used in the treatment of allergies without any observed side effects. This drug may act by inhibition of the synthesis of L-amino acids or vitamin B6, which are required for cell division. It may also have an effect on alkylating DNA, leading to inhibition of protein synthesis.