Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Cyclobutylmethanesulfonamide is a ligand that binds to the benzene ring of the protein cryptochrome. It is used in the treatment of Alzheimer's disease, glaucoma, dementia, and hyperactivity. Cyclobutylmethanesulfonamide provides protection against parasitic infestations by inhibiting the growth of erythrocytes, leukocytes, and some helminths. This drug also has an agriculturally beneficial effect by acting as a parasiticide against insects such as beetles, flies, ticks, and lice. Cyclobutylmethanesulfonamide is structurally very similar to pyridines but with a sulfonyl group at position 4 instead of a hydrogen atom.

Versatile small molecule scaffold

Versatile small molecule scaffold

2,6-Dimercaptopurine (2,6-DMP) is an immunosuppressive drug that is used to prevent organ transplants from being rejected. It blocks the synthesis of DNA and RNA in cells by inhibiting the enzyme thymidylate synthase. The reaction mechanism involves a nucleophilic attack on the phosphorus atom of 2,6-DMP by a proton from water or another nucleophile such as urea or ammonia. 2,6-DMP is metabolized through a number of tautomeric forms, which are neutral and acidic in pH. One example of this is when 2,6-DMP reacts with hydrochloric acid to form a conjugate base that can be excreted in urine.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-2,3-dihydro-1H-inden-1-one is a nitrogen heterocycle that can be synthesized by an asymmetric synthesis. It has been shown to inhibit the proliferation of T cells in vitro and in vivo and to suppress the development of autoimmune diseases. 2-Chloro-2,3-dihydro-1H-inden-1-one binds to a receptor on T cells and inhibits the function of this receptor. The drug was also found to be effective against trichomonas vaginalis in mice, although it has not yet been tested on humans. 2CHDI reacts with malonic acid or pyrazine carboxylic acid under acidic conditions to form a molecule with two carbonyl groups. This reaction is synergistic with hydrogen fluoride (HF) as a catalyst, which can also react with water molecules to form hydrogen gas and hydrofluoric acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Fluorohexanoic acid is a synthetic chemical that belongs to the group of fluorinated aliphatic acids. It has been shown to inhibit the NS3 protease from hepatitis C virus. The hydroxy group on the 2-fluorohexanoic acid molecule allows it to cleave peptide bonds in proteins, which are necessary for their function. This chemical can be used as a linker between two proteins or other molecules that need to be attached together.