Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester is an inhibitor of acetylcholinesterase. It is a white solid that can be synthesized in two steps from commercially available starting materials. Inhibition of this enzyme leads to the accumulation of acetylcholine, which causes increased stimulation of nicotinic and muscarinic receptors. This drug has been shown to have IC50 values that are similar to those of the reference inhibitor donepezil. 1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester also interacts with sulfonyl chlorides, butyrylcholinesterase, and other proteins in a manner similar to donepezil. The molecular docking studies suggest that this compound binds competitively with the active site of acetylcholinesterase.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6,8-Dimethoxyquinoline is a quinoline derivative that has been used to synthesize a number of other drugs. It has shown activity against cancer cells in vitro and in vivo and has been shown to have an anticholinergic effect on the central nervous system. 6,8-Dimethoxyquinoline also inhibits bacterial growth and is active against Gram-positive bacteria such as Enterococcus faecalis, Staphylococcus aureus, Streptococcus pyogenes, and Bacillus subtilis. This compound binds to the enzyme carbonic anhydrase II with high affinity. The binding of 6,8-dimethoxyquinoline with carbonic anhydrase II prevents the conversion of CO2 into carbonic acid, which may lead to cell death by inhibiting respiration.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold