Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methyloctanenitrile is an oxime that can be hydrocyanated to produce a regioselective addition product. This reaction is catalyzed by the presence of hydroxylamine, which acts as a ligand in the transition state. The reaction proceeds with anti-markovnikov selectivity, which is due to the hydroxyl group on the methyl group. This reaction has been optimized for frequency and rates of reaction, and can be used with aldoximes as well.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Pentafluorothio)benzaldehyde is a natural product that yields in the cancer cell. The fluorine atom has been shown to have a significant effect on the potency of this compound, with ligand binding affinities increasing by two orders of magnitude when fluorine is present. The 4-(Pentafluorothio)benzaldehyde exhibits nanomolar range activity against colon carcinoma cells and translocates inside these cells. This compound also inhibits nf-κb and chiral cycle, which are both important for cancer growth. 4-(Pentafluorothio)benzaldehyde has been shown to inhibit cancer cell proliferation in vitro and in vivo, demonstrating its potential as an anticancer drug.

5-Bromo-4-isopropylpyrimidine is an alkylating agent that forms a C–N bond with acylation reactions. This compound can be used as a substrate for acylation reactions and is catalyzed by copper or silver salts. 5-Bromo-4-isopropylpyrimidine reacts with carboxylic acids to form esters, which are useful for the synthesis of compounds such as corticosteroids. 5-Bromo-4-isopropylpyrimidine is also used in biomolecular chemistry to form acetal bonds with alcohols and other organic compounds.

Versatile small molecule scaffold

2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide Benzenesulfonic Acid is a molecule that binds to tropomyosin, a protein that is involved in the contraction of skeletal and cardiac muscles. This drug has been shown to inhibit the growth of viruses by binding to their nucleic acids and preventing them from replicating. It also inhibits chloride ion channels, leading to an increase in intracellular calcium levels. 2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide Benzenesulfonic Acid is used as a cytotoxic agent against tumor cells in cell culture experiments and transgenic animals. The drug can be used for the treatment of prostate cancer, breast cancer, and colon cancer.

Versatile small molecule scaffold

Versatile small molecule scaffold

DFPM is an organic compound with the chemical formula C8H6F3N. It has been shown to have a weak effect on the production of cytosolic Ca2+ in plant cells. DFPM also binds to and inhibits the activity of an unknown protein that is involved in regulating Ca2+ levels. The binding site for DFPM is located at the active site of this protein, which is located in the cytosol. The binding site for DFPM has not been identified.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold