Building Blocks

<p>Applications 3-Mercaptophenol is a versatile reactant used in the study of mechanism and catalysis of the native chemical ligation reaction. It was also used as a reactant in the synthesis and biological evaluation of HSP90 inhibitors based on molecular dynamic calculated conformational analysis of radicicol and its analogs.<br>References Moulin, E., et al.: J. Am. Chem. Soc., 127, 6999 (2005); Johnson, E., Kent, S.: J. Am. Chem. Soc., 128, 6640 (2006);<br></p>

<p>Applications Ethyl Carbazate is used in the synthesis of P1 aryl heterocycle-based thrombin inhibitors. It can be also used to prepare diazenedicarboxamides as inhibitors of alanylalanine ligase.<br>References Young, M., et al.: J. Med. Chem., 47, 2995 (2004); Kovac, A., et al.: Bioorg. Med. Chem. Lett., 17, 2047 (2007)<br></p>

<p>Stability Hygroscopic<br>Applications Dimethyl Phosphite is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.<br>References Suleimen, E.M., et al.: Chem. Nat. Compd., 50, 846 (2014); Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014)<br></p>

<p>Applications Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.<br>References Karoui, A., et al.: Med. Chem. Res., 23, 1591 (2014);<br></p>

<p>Applications Used in the preparation of phenyloxadiazolyl pyridines as immunomodulating agents.<br>References Iwakubo, M., et al.: Bioorg. Med. Chem., 15, 350 (2007), Schaafsma, D., et al.: Eur. J. Pharmacol., 585, 398 (2008),<br></p>

<p>Applications m-Toluoyl Chloride is used as a reagent in the synthesis of glycine benzamides as oral GPR139 receptor agonists. m-Toluoyl Chloride is also used in the preparation of colchicine derivatives which have potent anticancer activity and reduced P-glycoprotein induction liability.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dvorak, C.A., et al.: ACS Med. Chem. Lett., 6, 1015 (2015); Singh, B., et al.: Org. Biomol. Chem., 13, 5674 (2015)<br></p>

<p>Applications An intermediate in the formation of L-egothioneine, a natural amino acid ubiquitously present in cells and tissues of most plants and mammalian species. In humans, L-ergothioneine is found in red blood cells, liver, kidney, brain, seminal fluid, and cataract-free lenses at concentrations ranging from 100 uM to 2 mM. L-ergothioneine is exclusively biosynthesized in fungi and mycobacteria. Hence, humans assimilate it through dietary intake.L-ergothioneine has been proven to act as an antioxidant in vivo and to afford protection from g and UV radiation as well as from singlet oxygen in vivo. Recently, it has been shown that L-ergothioneine protects isolated perfused heart against the deleterious effect of post-ischemic reperfusion.The intermediate, 2-mercaptohistine has been used for the<br>References Makinen, K.K., et al.: Eur. J. Biochem., 123, 171 (1982), Howard, R.J., et al.: Biochem. Pharmacol., 35, 1589 (1986),<br></p>

<p>Applications 2-Acetylfluorene (cas# 781-73-7) is a useful research chemical.<br></p>

<p>Applications 3-Methoxybenzenethiol is a versatile reactant used in the preparation of sulfides by cuprous iodide catalyzed coupling with aryl iodides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kwong, F., Buchwald, S.: Org. Lett., 4, 3517 (2002);<br></p>

<p>Applications Intermediate in the preparation of Ertapenem (E635000).<br></p>

<p>Applications An intermediate in the preparation of a potential inhibitor of GAR Tfase.<br>References Cheng, H. et al.: Bioorg. Med. Chem., 13, 3593 (2005)<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Bromoacetyl Bromide, is a builidng block used for various organic synthesis. It can be used for the synthesis of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Toshima, K., et al.: Yuki Gosei Kagaku Kyokaishi, 70, 1187 (2012);<br></p>

<p>Applications 1,3-Benzothiazole-4-sulfonyl Chloride (cas# 149575-65-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Used for preparation of [[(triazolylmethyl)pyridyl]phenyl]tetrazoles and related compounds as cardiovascular agents.<br>References Behforouz, M., et al.: J. Med. Chem., 46, 5773 (2003), Behforouz, M., et al.: Bioorg. Med. Chem., 15, 495 (2007),<br></p>

<p>Applications An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity.<br>References Tomasi, J., et al.: Chem. Rev., 105, 2999 (2005), Godula, K., et al.: Science, 312, 67 (2006), Davies, H., et al.: Nature, 451, 417 (2008),<br></p>

<p>Applications Used as a reactant or reagent in preparation of N-alkyl carbamates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lazewska, D. et al.: BioMed. Chem. Let., 19, 6682 (2009);<br></p>

<p>Applications Ammonium sulfide is a very useful reagent in various aspects ranging from large scale production of textile manufacture, trace metal analysis, patina to bronze, and as well as cell culture and organic reactions/synthesis. Recently it has been used as a cleaning solution in the study of semiconductor growth on indium phosphide with various metals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferrandis, P., et al.: J. Appl. Phys., 123, 161534/1-161534/10 (2018)<br></p>