Building Blocks

<p>Stability Moisture Sensitive<br>Applications 10-Bromodecanol can be used to synthesize rotaxane dendrimers. It can also be used to synthesize J2326, a molecule that induces neurite outgrowth in neuronal cells.<br>References Wei, W., et al.: Proc. Natl. Acad. Sci. USA 112, 5597 (2015); Chang, P., et al.: Neuropharmacology 92, 146 (2015)<br></p>

<p>Applications 4-Nitrobenzonitrile (cas# 619-72-7) is a useful research chemical.<br></p>

<p>Applications 4-Nitrobenzonitrile-d4 (CAS# 1219798-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Ethynylcyclohexanol is used in the preparation of 9-methyladenines used as adenosine receptor antagonists. Also used in the cycloadition of alkynes to organic azides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harada, H. et al.: J. Med. Chem. 44, 170 (2001); Zhang, L. et al.: J. Am. Chem. Soc., 127, 15998 (2005);<br></p>

<p>Applications Isobutyric Anhydride is used as a highly reactive and non-water producing acyl donor for hydrolase-catalyzed enantioselective esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, J.-H., et al.: Appl. Microbiol. Biot., 43, 402 (1995)<br></p>

<p>Applications 4-Pentenal acts as a reagent used in the screening of the phytochemical, antibacterial and cytotoxic activity of medicinal plant of Tamilnadu.<br>References Nameirakpam, N. D., et al.: Int. J. Pharm. Res. BioSci., 1 (2012)<br></p>

<p>Applications Ethyl 4-Iodobenzoate (cas# 51934-41-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Propyl Acetoacetate is used as a reagent in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists.<br>References Crespo, A., et al.: ACS Med. Chem. Lett., 4, 1031 (2013)<br></p>

<p>Applications A precursor to 3-Methyl-2-butenyl-1-thiol which is very unstable. We will provide a detailed procedure for the preparation of the thiol from the thiolacetate with spectral data upon request.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Dimethyl Phosphite is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.<br>References Suleimen, E.M., et al.: Chem. Nat. Compd., 50, 846 (2014); Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014)<br></p>

<p>Applications 3-Ethylsalicylaldehyde is an intermediate in the synthesis of thiosemicarbazones, inhibitors of lysophosphatidic acid acyltransferase.<br>References PCT Int. Appl. (2015), WO 2015157242 A1 20151015. Johnston, E V., et al.: J. Org. Chem., 75, 4596 (2010);<br></p>

<p>Applications 6-Chloro-1-hexanol is used as a reagent in the synthesis of 3-(4-Chloro butyl)-1H-indole-5-carbonitrile; a key intermediate of the antidepressant drug Vilazodone (V265000).<br>References Anitha, N., et al.: Synthetic Commun., 44, 3563 (2014)<br></p>

<p>Applications An intermediate in the formation of L-egothioneine, a natural amino acid ubiquitously present in cells and tissues of most plants and mammalian species. In humans, L-ergothioneine is found in red blood cells, liver, kidney, brain, seminal fluid, and cataract-free lenses at concentrations ranging from 100 uM to 2 mM. L-ergothioneine is exclusively biosynthesized in fungi and mycobacteria. Hence, humans assimilate it through dietary intake.L-ergothioneine has been proven to act as an antioxidant in vivo and to afford protection from g and UV radiation as well as from singlet oxygen in vivo. Recently, it has been shown that L-ergothioneine protects isolated perfused heart against the deleterious effect of post-ischemic reperfusion.The intermediate, 2-mercaptohistine has been used for the<br>References Makinen, K.K., et al.: Eur. J. Biochem., 123, 171 (1982), Howard, R.J., et al.: Biochem. Pharmacol., 35, 1589 (1986),<br></p>

<p>Applications Adipoyl Chloride can be used in the synthesis of nylon. Also it is used in the synthesis of chiral polymer for membrane application.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaymans, R. et al.: J. Polym. Sci., 15, 535 (1977); Hazarika, S. et al.: Polym. J., 41, 1067 (2009);<br></p>

<p>Applications 4-Chloro-2,6-dimethoxypyrimidine (cas# 6320-15-6) is a compound useful in organic synthesis.<br></p>