Building Blocks

<p>Applications 2-Butynoic Acid is used as a reagent in the synthesis of BMS 911543 (B596075); a potent JAK2 inhibitor used as a potential treatment for myeloproliferative disorders. 2-Butynoic Acid is also used in the preparation of chirally pure 1,2,3,4-tetrahydroisoquinoline analogs as anti-cancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fitzgerald, M.A., et al.: J. Org. Chem., 80, 6001 (2015); Ramanivas, T., et al.: Eur. J. Med. Chem., 92, 608 (2015)<br></p>

<p>Applications Phenyl chloroformate is a corrosive liquid that is used to synthesize Urazole, a five membered heterocyclic compound that reacts with aldoses to form α and β pyranosides and furanosides. Phenyl chloroformate is also used as a reagent to prepare Sorafenib (S676850), a multikinase inhibitor that targets the tumour and tumour vasculature in patients with melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boettecher, B. &amp; Meister, A.: Anal. Biochem., 138, 449 (1984); Chai, W., et al.: Tetrahedron Lett., 53, 3514 (20112); Eisen, T., et al.: Brit. J. Cancer, 95, 581 (2006); Kolb, V., et al.: J. Mol. Evol., 38, 549 (1994); Llovet, J., et al.: Engl. J. Med., 359, 378 (2008)<br></p>

<p>Applications 2-Bromobenzoic acid is a sterically hindered ortho-bromo compound that is used as a starting material to synthesize quinazolinones (e.g. 8-Hydroxy-2-methyl-4(3H)-quinazolinone [H948330]).<br>References Liu, X., et al.: Angew. Chem. Int. Edit., 121, 354 (2009); Lu, G., et al.: Tetrahedron Lett., 46, 4255 (2005)<br></p>

<p>Applications 1-Heptyne can be used for cycloisomerization of alkynyl imines and alkynylation of oxiranes.<br>References Kel’in, A. V., et al.: J. Am. Chem. Soc. 123, 2074 (2001); Yamaguichi, M., et al.: Tetrahedron Lett. 24, 391 (1983)<br></p>

<p>Applications 2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.<br>References Baker, W., et al.: J. Chem. Soc., 2303 (1948);Friden-Saxin, M., et al.: J. Med. Chem., 55, 7104 (2012)<br></p>

<p>Applications A regent used for the synthesis of HIV-1 protease inhibitors and antiplasmin drugs<br>References Isoda, S., et al.: Chem. Pharm. Bull., 28, 2329-36 (1980), Melnick, M., et al.: J. Med. Chem., 39, 2795 (1996),<br></p>

<p>Stability Air Sensitive<br>Applications A potent agonist at hOR17-4 (a human testicular olfactory receptor) and acts as a strong chemoattractant in sperm behavioral assays. The bourgeonal-hOR17-4 signaling pathway potentially governs chemical communication between sperm and egg and may be used to manipulate or block fertilization. Bourgeonal is an aromatic aldehyde used in perfumery. It has a fragrance reminiscent of lily of the valley, otherwise described as floral, watery, green and aldehydic. It is a pale yellow liquid at room temperature.<br>References Spehr, M., et al.: Science, 299, 2054 (2003)<br></p>

<p>Applications trans-Cinnamoyl chloride (cas# 102-92-1) is a useful research chemical.<br></p>

<p>Applications 4-Chloropyridine n-oxide (cas# 1121-76-2) is a useful research chemical.<br></p>

<p>Applications 3-Methyl-3-(methylamino)butanoic Acid Methyl Ester is an derivative of substituted 3-pyrrolidinols with potential anticholinergic activities.<br>References Ryan, C.W., et al.; J. Org. Chem., 27, 2901 (1962);<br></p>

<p>Applications 1,4-Diidobenzene is used in single molecular bridging of Au nanogaps. It can also form copolymers with ethynylbenzenes in sponge to give elastic hydrophobic materials.<br>References Komoto, Yuki., et al.: J. Phys. Chem. C, 117(46), 24277-24282 (2013)<br></p>

<p>Applications 3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, R., et. al.: J. Med. Chem., 56, 6069 (2013)<br></p>

<p>Applications 1-Acetylnaphthalene is used in the preparation of S(-)-1-(1'-naphthyl) ethanol, an important synthetic intermediate of mevinic acid analog.<br>References Kamble, A.L. et al.: J. Mol. Catal. B Enzym., 35, 1 (2005); Bhattacharyya, M. et al.: Biores. Technol., 98, 1958 (2007);<br></p>

<p>Applications trans-3-Hexenedioic Acid is used as a starting material in the synthesis of Adipic Acid (A291590) which is primarily used in the synthesis of nylon.<br>References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012); Li, C., et al.: Electrochim. Acta, 56, 1529 (2010)<br></p>

<p>Applications 4-Nitrophenyl Phosphorodichloridate is used as a reagent in the synthesis of dihydrobenzodioxaphosphocine oxide derivatives which have antioxidant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Siva Prasad, S., et al.: J. Heterocyclic Chem., no vol., no pp. (2016, ahead of print)<br></p>

<p>Applications (E)-3-Hexenoic Acid is a useful organic reagent. It was used to design optically active selenium reagents with a chiral tertiary amino groups. It is a side-chain for penicillin F (CAS# 118-53-6).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fujita, K., et al.: Tetrahedron, 53, 2029 (1997);<br></p>