Building Blocks

Applications 4-Fluoroanisole-2,3,5,6-d4 (CAS# 1219802-94-4) is a useful isotopically labeled research compound.

Applications 2-Fluoroaniline-4,6-d2,ND2 (CAS# 1219804-77-9) is a useful isotopically labeled research compound.

Applications (4-Fluorophenyl)acetic-alpha,alpha-d2 Acid (CAS# 113715-48-3) is a useful isotopically labeled research compound.

Stability Moisture Sensitive
Applications 4-Fluorobenzoyl Chloride is used in the synthesis of tryphostins which act as inhibitors of EGF receptor and Erb82/neu tyrosine kinases. Also used in the synthesis of 1,2,4-triazole-3-thiones as antidepressant agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gazit, A. et al.: J. Med. Chem., 34, 1896 (1991); Kane, J. et al.: J. Med. Chem.,

Applications N-Methylpyrrole, is versatile building block use for the synthesis of more complex biologically active compounds. It can be used for the preparation of gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter, used for the treatment of renal disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hiroyuki, H., et al.: Kidney Intern., 79(1), 46 (2011); Shinohara, K. et al.: Anti-Cancer Drugs, 21(3), 228 (2010);

Applications 6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.
References Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23 (16), 4493 (2013);

Applications 4-Fluorobenzoyl-d4 Chloride (CAS# 1071809-52-3) is a useful isotopically labeled research compound.

Applications p-Fluorobenzyl Chloride is a chemical intermediate in the synthesis of various pharmaceutical and agricultural goods.
References Wang, J., et al.: J. Agr. Food. Chem., 59, 9892 (2011); Wang, J.M., et al.: J. Chem. Info. Model., 47, 1395 (2007); Yang, E., et al.: Rapid. Commu. Mass. Spectro., 19, 759 (2005); Cronin, M.T.D., et al.: Sci. Total. Environ., 204, 75 (1997);

Applications Methyl Propiolate is used as a reagent in the synthesis of a novel class of salicylic acid derivatives for inhibiting the protein tyrosine phosphatase YopH from Yersinia pestis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Paudyal, M.P., et al.: Bioorg. Med. Chem., 22, 6781 (2014)

Applications 4-Fluorobenzyl-alpha,alpha-d2 Chloride (CAS# 1219804-18-8) is a useful isotopically labeled research compound.

Applications 3-Fluorobenzoic Acid (cas# 455-38-9) is a compound useful in organic synthesis.

Applications 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid is a reactant used in the preparation of DPP-IV inhibitors.
References Kato, N., et. al.: Bioorg. Med. Chem, 19, 7221 (2011)

Applications 3-Fluorophenylmethylboronic acid pinacol ester

Applications 3-Fluoropicolinonitrile

Applications L-Valine-d8-N-FMOC (CAS# 1007834-06-1) is a useful isotopically labeled research compound.

Applications N-Fmoc-D-valine is an N-Fmoc-protected form of D-Valine (V094200). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.
References Chu, W., et al.: J. Am. Chem. Soc., 116, 7971 (1994); Gilbert, S & Migeon, B.: J. Cell. Phys., 92, 161 (1977); Salzman, L., et al.: J. Biol. Chem., 239, 1864 (1964); Sordillo, L., et al.: Cell Biol. Int. Rep., 12, 355 (1988)

Applications 3-Formyl-2-methylbenzoic Acid can be prepared to inhibit mTORC to treat cystic fibrosis.
References O’Neill, D.J., et.al., PCT Int. Appl., 565, (2018);