Building Blocks

Versatile small molecule scaffold

6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine is a subunit of the benzene ring. It has been shown to be an antagonist for the n-methyl-d-aspartate receptor (NMDA), which is involved in memory and learning. Studies have shown that 6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine has a dose dependent effect on forebrain activity and can be used as a medicinal drug. This drug can also bind to positron emission tomography (PET) radiotracers and it's radiometabolites are found in the brain. 6,7,8,9 tetrahydro -5H benzo[7]annulen 7 amine has been shown to be effective at treating diseases such as epilepsy and Alzheimer's disease.

Versatile small molecule scaffold

3-Bromo-4-fluorotoluene is a monomer that can be used in the synthesis of polymers. It reacts with trifluoroacetic acid, magnesium chloride, and a nucleophile to form 3-bromo-4-fluoroacrylic acid. This reaction takes place at room temperature and does not require a catalyst. The reaction time for this process is about 2 hours. 3-Bromo-4-fluorotoluene can also react with trichloroacetic acid to form 3,4-dibromofluorotoluene which is then reacted with chloride to form 3,3'-dichlorobenzidinium chloride. The diluent used in this process is usually tetrahydrofuran or dichloromethane. In bioconjugate chemistry, 3-bromo-4-fluorotoluene has been used to synthes

Versatile small molecule scaffold

4-Acetylbenzene-1-sulfonyl fluoride is a fluorinating reagent that is used for the derivatization of organic compounds. It reacts with chlorides to form sulfonium chloride, which can be detected by UV absorbance or by fluorescence. 4-Acetylbenzene-1-sulfonyl fluoride has been validated for use in the analysis of fluoride in solutions and has been shown to be effective for the determination of sulfonyl fluorides.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Bromobenzyl fluoride is a conformationally constrained amide that is used as an intermediate in the synthesis of antibiotics and vitamins. This chemical has been shown to be active against resistant strains of bacteria, such as methicillin-resistant Staphylococcus aureus. 4-Bromobenzyl fluoride has also been shown to be effective against some parasites and fungi. The mechanism of action for this drug is not known, but it may be due to its ability to act as a nucleophile and react with the phosphate group on the enzyme reductoisomerase. It has been synthesized using fluorine chemistry, which focuses on the structure of electron orbitals and how they interact with one another.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Guanidinobutanoic acid is a metabolite of creatine that is excreted in the urine. The metabolic profiles of 4-guanidinobutanoic acid have been determined in rat kidneys and compared to other metabolites, such as creatinine, gamma-aminobutyric acid, and urea nitrogen. Chronic exposure to 4-guanidinobutanoic acid leads to an increase in urea nitrogen and creatinine levels. It also causes a decrease in enzyme activities and uptake of creatine by the kidney. 4-Guanidinobutanoic acid has not shown any toxic effects on the kidney or any other organ system at concentrations up to 1000 mg/kg body weight per day.

2-Bromo-2-ethyl-3-methylbutanamide is a fatty acid which is a possible nonsteroidal anti-inflammatory drug. It is also used in the production of pharmaceutical dosage forms, and in the manufacture of other chemicals. This compound has been shown to have analgesic effects, as well as other pharmacological activities such as antiemetic, anesthetic, and vasodilator properties. 2-Bromo-2-ethyl-3-methylbutanamide is soluble in organic solvents but insoluble in water. It can be reconstituted with sodium citrate or sodium bicarbonate to form a sterile solution for injection. The reconstituted solution should be refrigerated and used within 24 hours.

3,3-Diethyl-5-methyl-1,2,3,4-tetrahydropyridine-2,4-dione is an insoluble hydrophobic implantable drug that can be reconstituted with a diluent and injected. It has been developed as a targetable drug delivery system for iontophoresis devices and has shown clinical effects in the treatment of various diseases. 3,3-Diethyl-5-methyl-1,2,3,4-tetrahydropyridine-2,4-dione is a bioactive agent that acts as an ion channel blocker. It inhibits the uptake of calcium ions into cells by blocking voltage gated calcium channels in the cell membrane. This leads to a reduction in intracellular free calcium concentration and subsequent inhibition of cellular activity.