Building Blocks

Versatile small molecule scaffold

5-Chloropyrazine-2,3-dicarbonitrile (5CPD) is an organochlorine compound that is used as a chlorinating agent in the production of alkyl and aralkyl chlorides. 5CPD is a monofunctional reagent that can also be used for the synthesis of furyl and thionyl chloride.

Versatile small molecule scaffold

N'-hydroxyquinoline-2-carboximidamide is a small molecule that was optimized for the treatment of cancer. It can bind to the DNA-dependent RNA polymerase, inhibiting transcription and replication. N'-hydroxyquinoline-2-carboximidamide selectively inhibits a hallmark signaling pathway in cancer cells, which leads to cell death. This compound has been shown to be effective in inhibiting the growth of tumor cells in various tissues including liver, lung, brain, and prostate. It also produces minimal side effects as it does not cross the blood brain barrier or enter the central nervous system.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methyl-4-nitrobenzaldehyde is an oxidizing agent that can be used as a phase transfer catalyst. It selectively transfers radicals from organic to inorganic systems and is used as a selective radical initiator or a transfer catalyst in high yield. 2-Methyl-4-nitrobenzaldehyde reacts with the chloride ion to produce an active radical, which will then react with the substrate to form products. It is typically used at refluxing temperatures and in the presence of a cocl2 phase transfer catalyst. 2-Methyl-4-nitrobenzoic acid is formed when 2-methyl-4-nitrobenzaldehyde is oxidized.

4-(Trichloromethyl)pyridine is an organic compound that can be used as a pesticide. It is the main active ingredient in chloropicrin, which is used primarily for agricultural purposes to help protect crops from insect damage. 4-(Trichloromethyl)pyridine has been shown to have toxic effects on animals, including humans, and may cause adverse health effects such as headaches, nausea, vomiting and dizziness. The chemical reacts with hydrogen chloride in the presence of an organic solvent to form the chlorinated derivative of 4-chloropyridinol. The reactivity of 4-(trichloromethyl)pyridine towards nucleophilic inorganic bases has also been studied and it was found that it reacts with potassium hydroxide at room temperature to form a 1:1 mixture of 4-chloropyridinol and potassium chloride.

1H-Isoindol-3-amine is a coordination complex with a palladium atom coordinated to three active methylene ligands. It is used as an intermediate in the synthesis of organic compounds. 1H-Isoindol-3-amine can be synthesized by the reaction of sodium hydrogen with hydroxybenzoic acid, followed by the Suzuki coupling reaction with copper chloride and an aryl chloride. The coordination chemistry between 1H-Isoindol-3-amine and palladium has been studied using viscosity measurements and X-ray diffraction data. The coordination complexes are usually based on aryl chlorides, which are electron rich, electron deficient, or electrophilic. The reaction mechanism for 1H-Isoindol-3-amine has been recorded.

Versatile small molecule scaffold

Versatile small molecule scaffold

S,S-Diphenyl sulfoximine is a sulfoxide with the chemical formula C6H6O2S. It has been used as a synthetic intermediate for the production of other chemicals. S,S-Diphenyl sulfoximine is also an efficient method for methylation reactions in organic solvents and radical coupling. In addition, it can be used to form functional groups with the functional theory and its analogs have been used as control experiments. S,S-Diphenyl sulfoximine is monosubstituted by two phenyl groups.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 5-amino-2-furoate is a nitrofuran that is used as a reagent in the synthesis of other compounds. It has been shown to be metabolized by acetylation, hydrazine, and reduction. Methyl 5-amino-2-furoate can also act as an inhibitor of xanthine oxidase and xanthine dehydrogenase. The compound has been shown to inhibit the production of xanthine and aminofuran in an incubated system containing these enzymes. Spectrometry analysis showed that methyl 5-amino-2-furoate was reduced to form methyl 2,5-dihydroxybenzoate during incubation with xanthine oxidase and xanthine dehydrogenase.

Versatile small molecule scaffold