Building Blocks

Versatile small molecule scaffold

2-Methyl-5-phenylpentanoic acid is a chiral, asymmetric catalyst for the hydrogenation of prochiral alkenes. It is prepared by the reaction of ferrocenyl phosphine with 2-methyl-5-phenylpentanoic acid. The product is obtained as a racemic mixture of enantiomers that can be separated by chromatography or crystallization.

Versatile small molecule scaffold

Research has shown that (4-Ethoxy-3-methoxybenzyl)amine (EMBA) is a potent inhibitor of bacterial growth. The alkylation of EMBA with methylamine and benzene leads to the formation of aureus, which is an antibiotic that can be used to treat staphylococcus infections. In addition, EMBA can also be methylated with hydroxylamine to form benzylamine, a compound that inhibits the synthesis of the cell wall in bacteria. These properties make EMBA an effective antimicrobial agent.

Versatile small molecule scaffold

Versatile small molecule scaffold

Rac-2,2'-Methylenebis(4-oxatricyclo[5.2.1.0,2,6]dec-8-ene)-3,5-dione is a polyvalent anhydride that has been used as a crosslinking agent in epoxy resin systems and as a viscosity modifier in polymerizable systems. It is also used as an additive to improve the properties of powder coatings and to produce polycarboxylic acid dispersions for use in alkyd resins and oil field chemical additives. The material is supplied as a colloidal suspension in water with a particle size of less than 1 micron. Racemic 2,2'-Methylenebis(4-oxatricyclo[5.2.1.0,2,6]dec-8-ene)-3,5-dione (rac-(1R,2S,6R,7S)-

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 2-(indol-3-yl)-2-oxoacetate is a hydroxy derivative of the amino acid tyrosine. It inhibits the enzyme tyrosine hydroxylase, which catalyzes the conversion of tyrosine to L-DOPA. This in turn affects dopamine synthesis and has an inhibitory effect on rat brain. Ethyl 2-(indol-3-yl)-2-oxoacetate also inhibits methylmagnesium borohydride in vitro, which is a reagent that breaks down esters, amides, and nitriles. Tyrosine hydroxylase is inhibited by the presence of two hydroxy groups on the ethyl side chain and one hydroxy group on the indole ring. It can be used as a structural analogue for other drugs that are used to treat Parkinson's disease or depression.

2-Methyl-1,3-benzoxazol-4-ol is a planar torsion with a chloride. The crystal structure of 2-Methyl-1,3-benzoxazol-4-ol has been solved by XRD and the molecular weight was found to be 253.2 g/mol. The chemical formula for 2-Methyl-1,3-benzoxazol-4-ol is C11H12ClNO2.
The benzoxazole ring in 2 methyl 1,3 benzoxazole 4 ol is planar and contains two methyl groups on the 4 position. This molecule can exist as either cis or trans form depending on the geometry of the molecule. The cis form has two hydrogen atoms on the opposite side of the molecule to each other whereas in trans it has only one hydrogen atom on opposite sides of the molecule. These two forms are not interchangeable and have different physical properties such as

Versatile small molecule scaffold

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2-Hydroxyethyl benzoate is a model system that has been used to study the mechanism of hydrolysis of an ester with a hydroxyl group. The reaction products are a metal hydroxide and a chloride ion. 2-Hydroxyethyl benzoate is an antimicrobial agent that has shown activity against bacteria, fungi, and protozoa. It is thought to work by reacting with fatty acids in the cell membrane, leading to disruption of the membrane and leakage of cellular contents. It also reacts with chloride ions to form hydroxybenzoic acid and water molecules. The activation energy for this reaction was found to be around 19 kJ mol−1.

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.

Versatile small molecule scaffold

1-Hydroxycyclopentane-1-carbonitrile is a monomer that is hydrolyzed to form benzoin and cyanohydrins. It can be used in the production of scifinder as a monomer or dimerizer.

Versatile small molecule scaffold

3-Hydroxy-5-methylpyridine (3HMP) is a chemical substance that has been classified as an amine. It is a product of the metabolism of purines, which are nitrogenous bases found in DNA and RNA. 3HMP is produced by aerogenic bacteria (such as Enterobacter), and can be used to estimate the number of these bacteria present in water samples. 3HMP has been shown to have antiviral properties against influenza virus, and can be used as a biomarker for the presence of other viruses in animals. 3HMP also has mineralization properties, which have been studied extensively, particularly with regards to pancreatic disease.

4,5-Dihydroxy-2,3-pentanedione is a carbonyl compound that is the product of the oxidation of ascorbic acid. It is used in wastewater treatment and has antimicrobial properties against infectious diseases. This compound has been shown to inhibit protein synthesis by binding to the ribosome and preventing the formation of peptide bonds between amino acids. 4,5-Dihydroxy-2,3-pentanedione has also been shown to bind to plasma proteins, which may be due to its acyl chain structure. 4,5-Dihydroxy-2,3-pentanedione can be synthesized in a catalytic mechanism that involves dehydroascorbic acid and molecular oxygen.

Piperyline is an alkanoic acid that has shown to be effective against skin cancer. It also has antimicrobial properties, which may be due to its ability to bind metal ions and form polymeric compounds. Piperyline inhibits microbial growth by inhibiting the synthesis of proteins and nucleic acids. The antimicrobial activity is related to its cationic polymerization with hydroxyl groups, which forms a structure that can inhibit microbial enzymes and disrupt microbial cell membranes. This compound also interacts with the skin's natural lipids, making it difficult for microorganisms to attach and grow on the skin. Piperyline is synthesized in organic chemistry laboratories as an amide precursor of other pharmaceuticals such as penicillin.