Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzothiadiazole-7-carboxylic acid (BTHCA) is an activated compound that has been shown to have potent bactericidal activity. It is a member of the benzothiadiazole family of compounds, which are found in the environment and have been detected in human blood. BTHCA inhibits the enzyme hydroxycinnamoyltransferase, which leads to a decrease in shikimate production and folate levels. BTHCA also reversibly inhibits methionine synthase, leading to an accumulation of homocysteine and methionine, which are toxic substances that lead to DNA damage and cell death. This compound has been used as a pesticide for plants by blocking plant protein synthesis. Analysis of BTHCA has shown it is metabolized into p-coumaric acid, which may be responsible for its observed anti-inflammatory effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Chloromethyl propyl carbonate is a pyrimidine compound that has been proposed as a potential cancer drug. It has shown high resistance to the enzymes fatty acid synthase and tenofovir and has shown antiviral properties against HIV, herpes simplex, and hepatitis B. Chloromethyl propyl carbonate inhibits the production of acyclic nucleoside phosphonates. It also inhibits fatty acid synthesis by binding to the enzyme acyl-CoA synthetase 2. Chloromethyl propyl carbonate binds to nitrogen atoms in the active site of the enzyme glutamine synthetase, thereby inhibiting its activity. The pharmacokinetic properties of chloromethyl propyl carbonate have been studied in rats and dogs; it is absorbed orally with rapid distribution into tissues, including fat, liver, kidney, lung, and brain. The drug is metabolized by carboxyesterases in the liver and excreted in urine</p>

<p>1-Chloro-2,3-dihydro-1H-indene is a kinetic inhibitor. It has been shown to bind to the enzyme quinoline synthesis and to be reactive towards chloride ions. 1-Chloro-2,3-dihydro-1H-indene is used as an intermediate in the production of styrene. This monomer has high values for constant rate kinetics and exhibits a high affinity for chloride ions, which makes it a good candidate for use in polymerization reactions. The chlorine atom can be substituted with other atoms or groups, such as ethyl groups, halides, or transfer reactions. These derivatives are also known as quinoline derivatives.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,2-Dimethylcyclobutan-1-ol is an organic compound that belongs to the class of cyclopropanes. It is a stereospecific reaction product of 2,2-dimethylcyclopropanecarboxylic acid and sodium ethoxide in ethanol. This compound can be used as a chiral synthon for the synthesis of cyclopropane derivatives. The optical activity of this compound has been shown to be dependent on the configuration at the chiral center.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-(4-Bromophenyl)-5-oxovaleric acid is a molecule that has been synthesized to be used as a cancer drug. It is an amide derivative of the natural compound valproic acid and is being developed for the treatment of cancers, such as leukemia and melanoma. 5-(4-Bromophenyl)-5-oxovaleric acid has been shown to inhibit the function of integrin, which plays a role in cell adhesion and migration, with potential applications in wound healing. <br>The molecule has also been shown to have chemokine binding properties and may be useful in the treatment of diseases where chemokines are involved, such as HIV or AIDS. This compound also binds to CCR5 receptor and inhibits HIV entry into cells. The molecule has also been shown to antagonize survivin, an antiapoptotic protein that protects cells from undergoing apoptosis and prevents tumor suppression. The affinity of 5-(4-bromophenyl</p>

<p>3,5-Dichloro-2-hydroxybenzene-1-sulfonamide is a defoliant that was first developed in the 1950s. It is a desiccant that damages plants by blocking photosynthesis and causes leaf shedding. 3,5-Dichloro-2-hydroxybenzene-1-sulfonamide is used on cotton plants to control weeds and promote plant growth. This sulfonamide herbicide also has the ability to kill insects, such as potato beetles, which are harmful to crops.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Cyclooct-4-enol is a constant, synthesize, and uptake that has been studied using X-ray crystallography. Cyclooct-4-enol is not resistant to bladder cancer cells, but is resistant to molecular imaging probes such as acetonitrile. Cyclooct-4-enol can be used as a ligand in luminescent probes to help target cancer cells. There are two strategies for cyclooct-4-enol: hypervalent and second order rate constants. Hypervalent strategy would involve changing the hydrophobic groups on the molecule so that it can be more easily absorbed by the cell membrane, while the second order rate constant strategy would involve attaching a ligand to the molecule that targets specific cancer types.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-5-methoxy-1H-indole is an indole that can be synthesized in two steps from 3,4-dibromobenzene. It is a potassium salt that reacts with potassium t-butoxide to produce a mixture of potassium bis(3-bromoindolyl) and potassium bis(5-methoxyanilino). The product can be purified by recrystallization. 3-Bromo-5-methoxy-1H-indole has been used for Suzuki coupling reactions with various boronic acids or boronates.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>