Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Iodo-N-methylbenzamide (2IMB) is a compound that has been shown in preliminary studies to have a high nucleophilic attack rate. It reacts with palladium complexes to form a stereoselective reaction and, when coupled with amide, aminosulfonyl, or tnf-α, can be used as an excellent model system for inflammatory diseases. 2IMB has also been shown to have anti-inflammatory properties by inhibiting prostaglandin synthesis. The deuterium isotope effect is the most important factor in determining the reactivity of the molecule. This effect causes the substitution of hydrogen atoms by deuterium atoms at various points on the molecule and affects the reaction yield.

5-Propyloctanoic acid is a fatty acid that is structurally related to octanoic acid. It has been shown to cause nerve demyelination in rats and mice, as well as sciatic nerve lesions in rabbits. 5-Propyloctanoic acid can be used as a potential antiepileptic drug, with anticonvulsant properties. This fatty acid also has the ability to inhibit lipoperoxide (LOOH) production by binding to LOOH and preventing its formation. The uptake of 5-propyloctanoic acid into cells is mediated by an uptake system, which may be inhibited by other chemicals.

4-Isocyanato-4,5,6,7-tetrahydro-1-benzothiophene is a urea derivative that is used as an herbicide. It is a member of the class of pesticides known as isothiocyanates and has been shown to be toxic to animals. 4-Isocyanato-4,5,6,7-tetrahydro-1-benzothiophene inhibits the production of urea in mammals by binding to the enzyme ornithine transcarbamylase (OTC). This binding prevents the formation of carbamoyl phosphate and argininosuccinate from ammonia and citrulline. The inhibition of this enzyme leads to decreased synthesis of arginine and eventually cell death.

Versatile small molecule scaffold

3-Ethylpentanoic acid is a fatty acid that is naturally found in the human body and can be synthesized by the body from other fatty acids. 3-Ethylpentanoic acid has been shown to inhibit histone deacetylase (HDAC) activity, which may be a possible mechanism for its antitumor effects. HDAC inhibitors are being studied as potential anticancer drugs. 3-Ethylpentanoic acid also inhibits the enzymatic activity of fatty acid synthase, thereby preventing the production of branched-chain fatty acids that are toxic to the liver. In addition, 3-ethylpentanoic acid has been shown to have pharmacokinetic properties in rats and mice with high levels of enzymes that convert it into a more hydrophobic form, which may lead to better absorption from the gastrointestinal tract and decreased metabolism by enzymes in the liver.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold