Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Methyl-3-phenylpiperidine is a tertiary amine that contains a quaternary carbon. It has three different conformers, which can be determined by the presence of trifluoromethanesulfonic acid. The tertiary amine has two hydrogen atoms on the nitrogen atom and one hydrogen atom on the methyl group. 3-Methyl-3-phenylpiperidine is stable at room temperature in ethanol and preferentially reacts with sodium borohydride to form sodium N-(3-methyl-3-phenylpiperidinium) borohydride. This compound also has an electron withdrawing substituent, so it will have a higher thermodynamic stability than benzene or pyridinium salts.

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Cyclopropylurea is a synthetic anticancer drug that was originally developed as an antihypertensive agent. It has been shown to have inhibitory effects on cancer cells and inflammatory diseases, including cyclic nucleotide phosphodiesterase (cNPD) and b-raf. 1-Cyclopropylurea also inhibits the synthesis of epoxyeicosatrienoic acids (EETs) in vitro, suggesting that it may be useful for the treatment of cardiovascular diseases such as hypertension.
1-Cyclopropylurea has been shown to inhibit cell proliferation in culture by causing G2/M phase arrest and apoptosis. The mechanism of action of 1-cyclopropylurea is not well understood, but it has been suggested that the drug prevents the phosphorylation of b-raf, which prevents the activation of mitogen activated protein kinases (MAPKs).

N-Methyl-1,3-benzoxazol-2-amine is a linker molecule that has been used in the synthesis of chlorides, molecular ions, trifluoroacetic acid, bromoacetone, yields and benzyne. It is also a precursor to the synthesis of benzoxazoles and alkylhalides. This compound reacts with cyclization reactions such as imino and benzoxazole. N-Methyl-1,3-benzoxazol-2-amine is also used in the gas phase to synthesize phenacyls.

Versatile small molecule scaffold

The isoxazole ring of 3-(pyridin-4-yl)isoxazol-5-amine is stabilized by hydrogen bonds. The orientation of the pyridine ring and the two asymmetric carbon atoms result in a chiral center. The molecule has two possible structures. The result of this is a molecule that can be stabilized with one or the other configuration, depending on how it is synthesized.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Biphenyl-4-thiol is a biphenyl derivative that is used in the treatment of fatty acid oxidation disorders. It is a lipophilic molecule that accumulates in red blood cells and can be detected by surface-enhanced Raman spectroscopy. Biphenyl-4-thiol has been shown to interact with the lipid bilayer, which may be due to its ability to form monolayers on the surface of red blood cells. The dipole moment of biphenyl-4-thiol causes an accumulation of electrons on one side of the molecule, which leads to electrochemical impedance changes upon exposure to electromagnetic radiation. X-ray absorption studies have shown that biphenyl-4-thiol has good chemical stability, which may be due to its aromaticity.

4-Chloro-8-nitroquinazoline is a potent antiproliferative agent that binds to the FGFR3 receptor and inhibits the proliferation of bladder cancer cells. It also has potent activity against bladder cancer cells in culture and inhibits cell growth by binding to submicromolar concentrations of this protein. 4-Chloro-8-nitroquinazoline may be useful for the treatment of bladder cancer, which is a disease characterized by uncontrolled cell division. This drug can inhibit proliferation of bladder cancer cells by interfering with their ability to signal through FGFR3 receptors, thereby inhibiting the activation of downstream signaling pathways that regulate cell cycle progression.

2-Amino-5-acetylpyridine is a potent adenosine kinase inhibitor. It binds to the ATP site of the enzyme and inhibits the production of ATP, which is necessary for the normal functioning of cells. 2-Amino-5-acetylpyridine has been shown to be orally bioavailable in rat studies. In computational studies, it was found that analogues with a longer side chain may provide greater potency and oral bioavailability. Computational studies also revealed that 2-amino-5-acetylpyridine may have selectivity for adenosine over other substrates.

2-(Piperidin-2-yl)acetic acid (2-PA) is a coordination complex that binds to the l-tartaric acid ligand, which is an amide. This compound may be used to treat urinary infections and fatty alcohols. 2-PA has shown anticancer activity in vitro and in vivo against a wide range of cancer cells. 2-PA also inhibits the production of isoflavonoid, which is a plant hormone that has been shown to possess anticancer properties. It also has been shown to have anti-inflammatory effects and can inhibit lipase activity. This compound can be synthesized using organic solvents at temperatures between -20°C and 180°C.