Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-(Benzyloxy)pentanal is a quinoline derivative that inhibits the enzyme reverse transcriptase, which is an extracellular enzyme that synthesizes DNA from RNA. It also inhibits nucleotide synthesis and interacts with other enzymes such as DNA polymerase. 5-(Benzyloxy)pentanal has been shown to inhibit tumor growth by inhibiting the production of cancer-related proteins. The compound was synthesized in a stereoselective manner by reacting piperidine with allyl bromide followed by oxidation to form the corresponding aldehyde. This method was used to produce an enantiomerically pure compound, which exhibits inhibitory activity against HIV-1 integrase.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

9-Methylfluorene-9-carboxylic acid is an organic compound that has a benzyl group attached to the 9th carbon of the fluorene ring. It is a colorless solid with a melting point of -78.5 °C. The synthesis of this compound involves the reaction of 9-fluorenone with diethyl ether in the presence of formic acid and phosphorous pentoxide. This reaction results in the formation of 9-methylene-9-fluorene, which is then oxidized to form 9-methylanthracene. Finally, methanol is added to form 9-methylfluorene-9-carboxylic acid. The molecular weight for this compound is 152 g/mol and it has an mp at -78.5 °C and bp at 138 °C. This compound can be used as a fingerprinting agent due to its characteristic UV absorption spectrum, which peaks

Versatile small molecule scaffold

4-(Hexyloxy)phenyl]methanol (4-HPMA) is a liquid crystal and crystalline compound that is synthesized from an aryl group. 4-HPMA has been used in the production of devices such as liquid crystal displays, and is currently being investigated for use in crystalline compounds. Its mesogenic properties have made it useful for the production of crystalline materials with a high melting point, and its aryl ring structure makes it suitable for use in organic crystals.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 2-cyano-2-cyclohexylacetate is an organic compound that belongs to the group of cycloaliphatic amides. It is a colorless liquid with a camphoraceous odor. The molecule consists of two rings: one of these is an aromatic ring, and the other is a saturated cycloalkane ring. This compound is prepared by the saponification and decarboxylation of camphene. Ethyl 2-cyano-2-cyclohexylacetate has been shown to react with hydrochloric acid to form nitro compounds, which are gaseous at room temperature. At higher temperatures, it decomposes into peroxides, peroxide, and isopropyl radicals.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Sodium 2-fluorobenzene-1-sulfinate is an arylation agent that can be used to synthesize substituted phenols. It is a regioselective reagent, which means it only reacts at the para position of the aromatic ring. The carbonate group can be removed by treatment with tripotassium phosphate in acidic solution, yielding the corresponding n-oxide. Sodium 2-fluorobenzene-1-sulfinate can also be used for palladium-catalyzed arylating reactions. This reaction requires a stoichiometric amount of triphenylphosphine and yields excellent yields. It reacts with diphenylphosphine to form the corresponding oxide in high yield. Sodium 2-fluorobenzene-1-sulfinate is commercially available and synlett has been reported.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Azepane-1-carbonyl chloride is a molecule that has been shown to be efficacious in the treatment of trypanosomiasis. It is a urea derivative that works by inhibiting the activity of a specific enzyme, adenylate kinase, which is essential for the metabolism of nucleotides and nucleosides. Azepane-1-carbonyl chloride binds to this enzyme and prevents it from converting ATP into AMP, which leads to cell death. This molecule has been shown to have antiviral properties against murine leukemia virus and trypanosoma cruzi. However, it does not seem to work as well on human cells. The efficacy of azepane-1-carbonyl chloride in vivo has also been demonstrated using an animal model. The effects of this molecule are dose dependent and there may be potential for optimization by changing its structure or metabolic stability.

4,5,6,7-Tetrahydro-benzo[d]isoxazol-3-ol (THI) is a chromatic integrating device that utilizes an algorithm and coding to update circuitry and devices. THI interacts with the optical vector techniques in order to position itself. The circuitry updates in response to the interaction with the optical vector techniques. THI can be utilized for many purposes such as updating bandwidth, devices, or interaction.

Thieno[3,2-c]pyridin-4-ol is a thienopyridone that is an inhibitor of the bromodomain. It has been shown to inhibit the bromodomain, which is a protein domain that also binds acetylated histones. The inhibition of this domain leads to chromatin condensation and DNA compaction, inhibiting transcription and replication. Thieno[3,2-c]pyridin-4-ol has been shown to have anti-inflammatory effects in vivo and in vitro.