Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Chloro-9-(propan-2-yl)-9H-purine is an intermediate in the synthesis of nucleoside analogues. It is obtained by the catalyzed reaction of acetonitrile and purines, which undergoes regioisomerization to form a mixture of 6-chloro-9-(propyl)- and 6-chloro-9-(butyl)purine. This intermediate can be used for the alkynylation of amino acids or peptides with alkynes. The selective formation of one regioisomer can be achieved by using a chiral catalyst or by reacting with an optically active reagent such as (+)-camphor sulfonic acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ip7E is a neuroprotective agent that has been shown to be effective in the treatment of various neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. Ip7E is a small molecule that modulates the metabolism of cells and protects them from death by inducing changes in cell nuclei. It also prevents radiation-induced neuronal cell death. Ip7E has been shown to be effective when administered before or after the onset of disease, suggesting it may be a possible diagnostic for neurodegenerative diseases.
Ip7E binds to cellular membranes and stabilizes them against oxidative damage, thus protecting cells from death by apoptosis, necrosis, or autophagy. It also inhibits fatty acid synthase (FAS) activity and hepatic steatosis.
Ip7E has not yet been tested on humans but is being investigated as a potential drug target for neuroprotection in various neurological disorders.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

PhiKan 083 hydrochloride is a compound that binds to the response element in the promoter region of the gene. It is used for diagnosis and treatment of cancer, as well as other diseases such as inflammation and fibrosis. PhiKan 083 hydrochloride also has anti-inflammatory properties. It inhibits epidermal growth factor receptors, which may be due to its ability to bind to ubiquitin ligases and inhibit their activity. These interactions lead to decreased transcriptional regulation and reduced proliferation of cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Iodo-4-methylthiopyrimidine (2IMT) is a benzene derivative that is used in the treatment of melanoma. It has been shown to have cytotoxic and antiproliferative activities in vitro against human melanoma cell lines, as well as in vivo against melanoma cells in mice. 2IMT has been shown to inhibit the proliferation of human melanoma cells by binding to nucleic acid. This causes the cell cycle to arrest at the G1 phase, which leads to apoptosis. In addition, this drug inhibits DNA synthesis by inhibiting RNA polymerase II activity, leading to an increase in p53 levels and activation of p21 protein levels.