Ácidos y reactivos sintéticos

<p>Applications A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Chiu, T.A., et al.: J. Pharmacol. Exp. Ther., 252, 711 (1990), McIntyre, M., et al.: Pharmacol. Ther., 74, 181 (1997), Pitt, B., et al.: Lancet, 355, 1582 (2000);<br></p>

<p>Applications Girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H., et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R., et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications Ketanserin Tartrate is used in nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis for preventing a variety of diseases ranging from cancer to ischemic injury.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gohil, V. M., et al.: Nat. Biotechnol, 28, 249 (2010)<br></p>

<p>Stability Store in freezer<br>Applications Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine.<br>References Yoon, C., et al.: Mol. Cancer Res., 7, 361 (2009), Giussani, P., et al.: J. Biol. Chem., 284, 5088 (2009), Chen-Quay, S., et al.: J. Pharm. Sci., 98, 606 (2009), Satoh, Y., et al.: J. Biochem., 145, 31 (2009),<br></p>

<p>Impurity Atomoxetine EP Impurity E<br>Applications (S)-(+)-Mandelic Acid (Atomoxetine EP Impurity E) is an antiseptic (urinary).<br>References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007), Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009),<br></p>

<p>Applications AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>

<p>Applications MK8722 is a systemic, direct pan-activator of AMP-activated protein kinase.<br>References Feng, Danqing, et al.: ACS Med. Chem. Let., 9(1), 39-44 (2018);Myers, Robert W., et al.: Science, 357(6350), 507-511 (2017)<br></p>

<p>Applications Mirtazapine is an α2-Adrenergic blocker; analogue of Mianserin. Antidepressant.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Lead(IV) acetate is most commonly used in synthetic chemistry as an oxidizing agent, and is a versatile precursor for lead-containing compounds. Lead(IV) acetate is a toxic substance to humans, and is also known to induce oxidative damage and hyperlipidemia in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newairy, A., et al.: Food Chem. Toxicol., 47, 813 (2009); Rahman, S. &amp; Sultana, S.: Chem.-Biol. Int., 160, 61 (2006); Yadav, R.: Synlett, 2012, 1262 (2012)<br></p>

<p>Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Displays antibacterial properties due to the presence of the quaternary amine and the counter ion.<br>References Igalsbe, M. L. et al.; Bioorgan. Med. Chem Lett 19, 4984 (2009)<br></p>

<p>Applications Heptadecafluorooctanesulfonic acid tetraethylammonium salt (CAS# 56773-42-3) is a surfactant used in the electroplating process of various metals, such as chromium and nickel. Heptadecafluorooctanesulfonic acid tetraethylammonium salt is an environmental pollutant, and has been detected in processed foods.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Guo, L.; et al.: Guangdong Huagong, 42, 119 (2015); Wang, Z.; et al.: Environment International, 69, 166 (2014); Moreta, C.; et al.: J. Chromatogr. A, 1355, 211 (2014).<br></p>

<p>Applications CIL56 inhibits YAP/Tead transcriptional activity. Has anti-tumour effects on oesophageal adenocarcinoma with therapeutic potential in combination with 5-FU. Involved in ferroptosis, mediated by iron-dependent ROS.<br>References Dixon, Scott J., et al.: ACS Chemical Biology., 10, 1604 (2015); Shimada, Kenichi., et al.; Nature Chemical Biology., 12, 497 (2016)<br></p>

<p>Applications Pyridine-Sulfur Trioxide Complex is used in the sulfation of squid ink polysaccharides (SIPs) as a potential candidate compound for the prevention of tumor metastasis. Pyridine-Sulfur Trioxide Complex is also used in the preparation and anticoagulation test of sulfated silk fibroin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, S. et al.: Carb. Polymers, 81, 560 (2010); Li, S. et al.: Canya Kexue, 36, 553 (2010);<br></p>

<p>Applications β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions.<br>References Chung, C.H., et al.: Calcif. Tissue. Int., 51, 305 (1992);<br></p>

<p>Applications 1-Hexyne is a reagent used in the preparation of triazole hydroxamic acid derivatives as selective MMP-2 inhibitors using click chemistry. 1-Hexyne is a potent inhibitor of nitrification in soil. A reagent for the preparation of functionalized isoindolinones via ring closing metathesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zapico, J., et al.: Anales de la Real Academia Nacional de Farmacia, 77, 99 (2011); El-Sayed, S., et al.: Alexandria Sci. Exchange, 24, 327 (2003); Pierce, J. G., et al.: J. Organomet. Chem., 692, 4618 (2007)<br></p>

<p>Applications A synthetic, quaternary ammonium anticholinergic. Antispasmodic; preanesthetic medicant.<br>References Kaltiala, E., et al.: J. Pharm. Pharmacol., 26, 352 (1974), Kongsrud, F., et al.: Acta Anaesthesiol. Scand., 26, 620 (1982),<br></p>

<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>

<p>Applications BENZAMIDINE (cas# 618-39-3) is a useful research chemical.<br></p>

<p>Applications Dibutyltin(IV) Oxide is used in studies pertaining to discovering novel antitumor agents. Antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boualam, M. et al.: App. Organometal. Chem., 6, 197 (1992); Hadi, S. et al.: Ori. J. Chem., 26, 775 (2010); Hadi, S. et al.: Modern. App. Sci., 3, 12 (2009);<br></p>

<p>Applications An aromatase inhibitor. Also blocks adrenal steroidogenesis.<br>References Santen, R.J. and Misbin, R.I.: Pharmacotherapy, 1, 95 (1981), Havlin, K.A. and Trump, D.L.: Cancer Threat. Res., 39, 83 (1988)<br></p>

<p>Applications (R)-(+)-α-Methylbenzylamine (cas# 3886-69-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Tin(II) Acetate is used in stannous oral care compositions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Surerus, K., et al.: Biochemistry, 1994, 33, 4980 (1994),<br></p>

<p>Impurity Paclitaxel - impurity G<br>Applications A semi-synthetic precursor of Paclitaxel. Paclitaxel - impurity G.<br></p>

<p>Applications A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.<br>References Pugazhenthi, U. et al.: Diabetol., 53, 2357 (2010); Li, C. et al.: Bioche,. Biophys. Res. Comm., 400, 563 (2010); Lupi, R. et al.: Diab. Obes. Metab., 10, 515 (2008); Kim, T.H. et al.: Bioconj. Chem., 22, 625 (2011);<br></p>

<p>Applications 1,3-Diaminopropane is a common chemical reagent, used in the synthesis of 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors applied in the treatment of Alzheimer’s disease. Also used in the synthesis of thrombosis inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spilovska, K. et al.: Molecules, 18, 2397 (2013); Smith, S. et al.: Blood, 120, 5103 (2012);<br></p>

<p>Applications Reagent used to produce chiral salts.<br>References An, J., et al.: J. Med. Chem., 52, 2667 (2009),<br></p>

<p>Stability Moisture and Temperature Sensitive<br>Applications Benzohydroxamic Acid (cas# 495-18-1) is a compound useful in organic synthesis.<br>References Siliphaivanh, P., et al.: Bioorg. Med. Chem. Lett., 17, 4619 (2007), Serafimova, R., et al.: Chem. Res. Toxicol., 20, 1225 (2007), Fielding, A., et al.: Biochem., 47, 9781 (2008),<br></p>

<p>Applications (1R,3S)-Camphoric Acid is used primarily as a reagent in syntheses of crystalline structures. It is used in the preparation of polymeric transition metal dipyridylamine D-camphorate complexes.<br>References Blake, K. et al.: Crys. Growth Des., 12, 5215 (2012);<br></p>

<p>Applications Potassium Carbonate is a common chemical reagent used in various organic reactions. It is used, for example, in the synthesis of Diazoxon (D416890); the oxidized form of Diazinon (D416880) which is an organophosphate insecticide. Diazoxon is shown to be a more potent acetylcholinesterase (AChE) inhibitor.<br>References Lazarevic-Pasti, T. D., et al.: J. Electroanal. Chem., 692 (2013); Pasti, T. L., J. Environ. Protect. Ecology, 12, 1168 (2011)<br></p>

<p>Applications A caffeine metabolite which showed high antioxidant activity. It is a very sensitive biomarker for the consumption of relatively small amount of coffee.<br>References Buchanan, C., et al.: J. Sci. Food Agric., 71, 459 (1996), Andreasen, M., et al.: J. Agric. Food Chem., 49, 5679 (2001), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008),<br></p>

<p>Applications Isohexanol is used as a cosmetic compound with an antimicrobial effect especially deodorants.<br></p>

<p>Applications Labelled DL-Homocystine is used in the synthesis of potential antitumor agents through inhibition of L-asparagine. There is growing clinical evidence that elevated homocysteine levels are associated with an increased risk of venous and arterial thrombosis.<br>References Brynes, S. et al.: J. Pharm. Sci., 67, 1550 (1978); Lauricella, A. et al.: Thromb. Res., 107, 75 (2002);<br></p>

<p>Applications A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate. Potent Bcl-2 family inhibitor.<br>References Adams, J., et al.: Science, 281, 1322 (1998), Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (2001), Kitada, S., et al.: J. Med. Chem., 46, 4259 (2003), Danial, N., et al.: Clin. Cancer Res., 13, 7254 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Vitamin (enzyme cofactor). Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004),<br></p>

<p>Impurity Roxatidine Impurity 3<br>Applications 3-Hydroxybenzaldehyde (cas# 100-83-4) is a compound useful in organic synthesis.<br></p>

<p>Applications WY 14643 is a potent peroxisome proliferator and activator of PPARα.<br>References Issemann, I., et al.: Nature, 347, 645 (1990); Staels, B,, et al.: Nature, 393, 790 (1998); Lee, S., et al.: Mol. Cell. Biol., 15, 3012 (1995)<br></p>

<p>Applications It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. It is useful as biomarker in human lung cancer cell. Potent MEK inhibitor.<br>References Ciardiello, F., et al.: Clin. Cancer Res., 7, 1459 (2001), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001),<br></p>

<p>Applications Bucindolol is a high-affinity, competitive beta blocker used in the treatment of congestive heart failure and hypertension.<br>References Hershberger, R., et al.: J. Cardiovasc. Pharm., 15, 959 (1990); Pollock, S., et al.: Am. J. Cardiol., 66, 603 (1990); Rotmensch, H., et al.: Am. J. Cardiol., 54, 353 (1984)<br></p>

<p>Applications MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.<br>References Indovina, P., et al.: Cancer Bilo. Ther., 15, 380 (2014);<br></p>

<p>Applications A silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products. Approximate M.W. 4000.<br>References Disapio, A. et al.: Int. J. Cosmet. Sci. 10, 75(1988)<br></p>

<p>Applications Rhodium(III) chloride is often used in synthetic chemistry as a hydrogenation catalyst. Rhodium(III) chloride is also used to make transition metal complexes, some of which are used as reagents in the decarbonylation dehydration reactions of fatty acids to alkenes.<br>References Foglia, T. &amp; Barr, P.: J. Am. Oil Chem. Soc., 53, 737 (1976); Hillis, J. &amp; DeArmond, M.: J. Lum., 4, 273 (1971); James, B. &amp; Rempel, G.: Can. J. Chem., 44, 233 (1966)<br></p>

<p>Impurity Ziprasidone EP Impurity A<br>Applications 3-(1-Piperazinyl)-1,2-benzisothiazole (Ziprasidone EP Impurity A) is a reagent used to synthesize Ziprasidone (Z485000, HCl salt, monohydrate), a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prakash, C., et al.: Brit. J. Clin. Pharmacol., 49, 35S (2000); Orjales, A., et al.: J. Med. Chem., 46, 5512 (2003); Graham, J., et al.: Bioorg. Med. Chem. Lett., 18, 489 (2008); Bench, C.J., et al.: Psychopharmacology, 112, 308 (1993), Goldstein, J.M.: Exp. Opin. Invest. Drugs, 4, 291 (1995)<br></p>

<p>Applications Iodine is used in ionic liquids in the preparation of dye-sensitized solar cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, P. et al.: J. Phys. Chem. B, 107, 13280 (2003); Kubo, W. et al.: J. Phys. Chem. B. 105, 12809 (2001);<br></p>

<p>Stability Light Sensitive<br>Applications Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamm, J.J., et al.: J. Am. Acad. Dermatol., 6, 652 (1982), Warrel, R.P., et al.: Leukemia, 8, 929 (1994), Sasai, Y., et al.: J. Neurol., 249, 41 (2002),<br></p>

<p>Applications LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.<br>References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);<br></p>

<p>Applications (-)-Terpinen-4-ol (cas# 20126-76-5) is a useful research chemical.<br></p>

<p>Applications A labelled nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.<br>References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),<br></p>

<p>Applications Zinc Sulfate Monohydrate is a special compound fertilizer for improving rapeseed yield.<br>References Liu, H., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications RK 33 is an inhibitor of DDX3, an ATP-dependent RNA helicase (1). Aberrant regulation of DDX3 is related to various diseases such as prostate and breast cancer (2). RK 33 was shown to decrease proliferation of prostate cancer cells and induced a G1 phase cell-cycle arrest (2).<br>References (1) Botlagunta, M. et al.: PLoS One. 6, e17563 (2011) (2) Xie, M., et al.: Cancer Res. 76, 6340 (2016)<br></p>

<p>Applications Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.<br>References Cook, P., James, I.: New England J. Med. 305, 1560 (1981); DeNoble, V., et al.: Pharmacol. Biochem. Be., 24, 1123 (1986)<br></p>

<p>Applications N-(2-Carboxy-2-hydroxycaproyl)hydrazobenzene is an impurity in the synthesis of pheylbutazone (P319570) derivatives.<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>

<p>Applications Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase.<br>References Arch. Biochem. Biophys., 221, 593 (1983), Clin. Biochem., 17, 3 (1984), Trends Bio. Sci., 9, 32, (1984), J. Biol. Chem., 260, 15873-15879 (1985), FEBS, 1985, 28 (1986)<br></p>

<p>Applications Halogenated derivative of Febrifugine. Used as an antiprotozoal (coccidiostat).<br>References McIntosh, L., et al.: Biochem. Cell Biol., 73, 181 (1995), Leshem, Y., et al.: Exp. Cell Res., 274, 288 (2002),<br></p>

<p>Applications Cognition enhancer related to Piracetam. Nootropic.<br>References Foltyn, P., et al.: Arzneim.-Forsch., 33, 865 (1983), Yamada, K., et al.: Pharmacol. Biochem. Behav., 22, 645 (1985), Schlappi, B., et al.: Drug Invest., 5, 50 (1993),<br></p>

<p>Applications (S)-(-)-Bupivacaine Hydrochloride is the salt analogue of a local anaesthetic used for epidural and intrathecal anaesthesia.<br>References Tullar, B., et al.: J. Med. Chem., 14, 891 (1971); Schmidt, A., et al.: Pharm. Res., 22, 2121 (2005)<br></p>

<p>Applications Alfuzosin (CAS# 81403-80-7) is a useful research chemical compound.<br></p>

<p>Applications 3-Ethylpentane (cas# 617-78-7) is a useful research chemical.<br></p>

<p>Stability Toxic<br>Applications 2-Chloro-4-methylpyrimidine (cas# 13036-57-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.<br>References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),<br></p>

<p>Applications Ammonium carbonate is a reagent that is used in the synthesis of D,L-Carbidopa (C175915 which is an inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963),<br></p>

<p>Applications L-2-Aminobutanol has potential application as an inhibitor of L-Fucosidases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blaser, A. et al.: Org. Lett., 2, 1733 (2000);<br></p>

<p>Applications Ammonium Chloride is used as a main component and source of nitrogen in fertilizer.<br>References Crill, P. et al.: Soil Biol. Biochem., 26, 1331 (1994); Zaman, M. et al.: Biol. Fert. Soils, 29, 178 (1999);<br></p>

<p>Applications Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);<br></p>

<p>Applications Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),<br></p>

<p>Applications A cholinergic receptor involved in the production of gastric acid. Cholinergic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ohshiba, Y., et al.: Chem. Pharm. Bull., 43, 1067 (1995), Chen, S., et al.: J. Pharmacol. Exp. Ther., 313, 765 (2005), Nangle, M., et al.: Br. J. Pharmacol., 148, 423 (2006),<br></p>

<p>Applications Potassium persulfate is an inorganic compound that is a strong oxidant. It is used in organic reactions for polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Garry, J. C., et al.: Bioorg. Med. Chem. Lett., 21, 4589 (2011);<br></p>

<p>Applications A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.<br>References Yamada, Y. et al.: Horm. Metab. Res., 40, 539 (2008); Kopelman, P. et al.: Int. J. Obes., 31, 494 (2007); Kopelman, P. et al.: Obesity, 18, 108 (2010);<br></p>

<p>Applications Mepindolol is a non-selective β-adrenoceptor blocking agent. Mepindolol is used in the treatment of glaucoma.<br>References Luque Otero, M. et al.: Br. J. Clin. Pharmacol., 17, 361 (1984); Beckmann, R. et al.: Arzneim.-Forsch., 36, 811 (1986);<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Orally active anthracycline; analog of Daunorubicin. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arcamone, F., et al.: Caner Treat. Rep., 60, 829 (1976), Zini, G., et al.: Cancer Chemother. Pharmacol., 16, 107 (1986), Gillies, H.C., et al.: Br.J. Clin. Pharmacol., 23, 303 (1987), Villani, F., et al.: Eur. J. Cancer Clin. Oncol., 25, 13 (1989),<br></p>

<p>Applications Antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kent, J., et al.: Lancet, 355, 911 (2000), Pacher, P., et al.: Curr. Med. Chem., 8, 89 (2001), Titier, K., et al.: Ther. Drug Monit., 25, 581 (2003), Eap, C., et al.: Ther. Drug Monit., 26, 152 (2004),<br></p>

<p>Applications Magnesium Chloride Hexahydrate is used in magnesium replacement therapy for those deficient in magnesium. Effective anaesthetic for cephalopods.<br>References Iezhitsa, I. et al.: Nutr. Neurosci., 14, 10 (2011); Culloty, S. et al.: Aquaculture., 107, 249 (1992);<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Applications Cupriethylenediamine Hydroxide is used as a solvent for cellulose.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, L., et al.: J. Applied Polym. Sci., 126, E244 (2012); Shi, W., et al.: Ind. Eng. Chem. Res., 52, 586 (2013); Cyrot, J., et al.: Bulletin de l'Institut Textile de France, 18, 211 (1964)<br></p>

<p>Applications Anticholinergic. Antispasmodic.<br>References Lundstam, S., et al.: Lancet, 1, 1096 (1982), Thompson, J., et al.: Br. Med. J., 299, 1140 (1989), Marthak, K., et al.: Curr. Med. Res. Opi., 12, 366 (1991), Panderi, I., et al.: J. Pharm. Biomed. Anal., 12, 151 (1994),<br></p>

<p>Applications D,L-2-Amino-3-phosphonopropionic acid is a phosphonate substituted derivative of Aspartic acid (A788955) and is a known antagonist of a receptor that is coupled to phosphoinositide metabolism in brain slices. D,L-2-Amino-3-phosphonopropionic acid is also an inhibitor of metabotropic glutamate receptors in rat brain.<br>References Hedberg, T. &amp; Stanton, P.: Eur. J. Pharma., 310, 19 (1996); Saugstad, J., et al.: Eur. J. Pharm.: Mol. Pharm., 289, 395 (1995); Schoepp, D., et al.: Mol. Pharm., 38, 222 (1990)<br></p>

<p>Applications WAY 127039-A-1 is a metabolite of Bromfenac sodium (B678550).<br>References Walsh, D.A., et al.: J. Med. Chem., 25, 446 (1982),<br></p>

<p>Stability Sensitive to moisture<br>Applications Isonicotinyl Chloride Hydrochloride, is a heterocyclic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the preparation of Tetrahydropyrroloquinolinone type dual inhibitors of Aromatase/Aldosterone Synthase, as a novel stagey for breast cancer patients with the risk of cardiovascular diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yin, L., et al.: J. Med. Chem., 56 (2), 460 (2013);<br></p>

<p>Applications A catalyst used in wide range of polymerization reaction. It has been used as a mild Lewis acid catalyst for the stereoselective Diels-Alder reaction as wel as in a Ziegler-Natta type catalyst system for the polymerization of 1,3-butadiene.<br>References Gong, D. et al.: Polymer, 50, 2826 (2009); Gorman, D. B. et al.: Chem. Comm., 1, 25 (2004);<br></p>

<p>Applications Larixol, is an intermediate in the synthesis of larixyl acetate. This compound is also found to have antibacterial activity and high potential antioxidant activity.<br>References Prideevech, P., et al.: Chiang Mai J. Sci, 40, 214 (2013)<br></p>

<p>Applications 1,1-Bis(hydroxymethyl)cyclopropane is used in the synthesis of morphine alkaloids. It also serves as an inhibitor of 5-lipoxygenase.<br>References Evans, D.A. et al.: Tetrahedron Lett., 23, 285 (1982); Arai, Y. et al.: J. Med. Chem., 26, 72 (1983);<br></p>

<p>Applications 1-(2,3-Epoxypropyl)-2-nitroimidazole is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.<br>References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)<br></p>