Ácidos y reactivos sintéticos

<p>Applications Tetrabutylammonium Bromide is used in the synthesis of polymer solar cells. Also used in the synthesis of single component green-light emitting electrochemical cells.<br>References Yun, H. et al.: Chem. A Eur. J., 19, 13242 (2013); Sun, M. et al.: J. Disp. Tech., 9, 476 (2013);<br></p>

<p>Applications 1,5-Diazabicyclo[4.3.0]non-5-ene is used as a nucleophilic catalyst for the Freidel-Crafts C-acylation of pyrroles and indoles. 1,5-Diazabicyclo[4.3.0]non-5-ene is also an inhibitor of indoleamine-N-methyltransferase (II) of rabbit lung in vitro.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandel, L.: Biochem. Pharmacol., 25, 2251 (1976); Taylor, J., et al.: Org. Lett., 12, 5740 (2010)<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Stability Unstable in Solution, Air Sensitive<br>Applications An antirheumatic agent.<br>References Masutani, K., et al.: Clin. Nephrol., 70, 464 (2008), Kobata, Y., et al.: Modern Rheumatol., 19, 629 (2009), Oki, K., et al.: Inflam. Res., 58, 571 (2009),<br></p>

<p>Applications Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases.<br>References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>

<p>Applications 1-Chloropentane is used for studies on the antimicrobial activity of some halogenated hydrocarbons and their derivatives, effect of chlorinated hydrocarbons on the myelin sheath of peripheral nerve tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kalatskaya, L. M., et al.: Fiziologicheski Aktivnye Veshchestva; 20, 77 (1988); Rumsby, M. G., et al.: J. Neurochem., 13, 1513 (1966)<br></p>

<p>Applications (+)-Muscarine Chloride modulates calcium channel currents in rats.<br>References Stewart, A. E., et al.: J. Neurophysiol., 81, 72-84 (1999);<br></p>

<p>Applications Bepotastine is a histamine H1 receptor antagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).<br>References Kaminuma, O. et al.: Biol. Pharm. Bull., 21, 411 (1998); Kitaba, S. et al.: J. Allergy, No pp. given (2008); Lyseng-Williamson, K.A., Drugs, 70, 1579 (2010);<br></p>

<p>Applications 3,3-Diphenylpropylamine is a metabolite of Prenylamine (P712800). 3,3-Diphenylpropylamine showed antiextensor effects as well as neuroexcitatory effects and antagonized barbital-induced loss of the righting reflex.<br>References Hornke, I. et al.: Arzneim.-Forsch., 20, 791 (1970); Remberg, G. et al.: Biomed. Mass Spec., 4, 197 (1977); Helke, C. et al.: Eur. J. Pharmacol., 48, 231 (1978);<br></p>

<p>Applications Vaborbactam is a non-β-lactam β-lactamase inhibitor. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the beta-lactamase enzymes that would otherwise degrade them. When combined with an appropriate antibiotic it can be used for the treatment of gram-negative bacterial.<br>References Hecker, S.J., et al.: Journal of Medicinal Chemistry, 58, 3682 (2015);<br></p>

<p>Applications Ethyl 3-Bromopyruvate is used in the preparation of 1,2,4-trisubstituted imidazoles as inhibitors of growth factor-β type I ALK5 inhibitors.<br>References Guo, C. et al.: Bioorg. Med. Chem. Lett., 23, 5850 (2013); Catarzi, D. et al.: Farmaco, 48, 447 (1993);<br></p>

<p>Applications RAD 140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM).<br>References Miller, C.P., et al.: ACS Med. Chem. Lett., 2, 124-129 (2011)<br></p>

<p>Applications Sofalcone is a substituted chalcone with anti-ulcer activity.<br>References Matsuo, Y., et al.: Arzneim. Forsch., 33, 242 (1983), Suwa, T., et al.: Jpn. J. Pharmacol., 35, 47 (1984),<br></p>

<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>

<p>Applications A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.<br>References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Bismuth(III) chloride (cas# 7787-60-2) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Used in tests for skin corrosivity.<br> E0<br>References Fentem, J.H., et al.: Toxicology in Vitro, 12, 483 (1998),<br></p>

<p>Applications 2-CHLOROSTYRENE (cas# 2039-87-4) is a useful research chemical.<br></p>

<p>Applications Allenylboronic acid pinacol ester<br></p>

<p>Applications 2,3-O-Isopropylidene-L-threitol is an intermediate in the synthesis of versicolactone compounds.<br>References Wang, L., et al.: Tetrahedron. Lett., 54, 6729 (2013);<br></p>

<p>Applications cis-1-Ethoxy-2-(tributylstannyl)ethene is used in the synthesis of (+)-pleuromutilin (P610500), an antibiotic substance produced by the basidiomycetes Pleurotus mutilus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fazakerley, N.J., et. al.: Chem. Eur. J., 19, 6718 (2013)<br></p>

<p>Applications 3-Chloro-2,4-pentanedione is an useful building block reagent in the preparation of organic compounds of research interest that has been studied as a possible β-​diketone for antitumor treatment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakano, K., et. al.: Anticancer Res., 24, 711 (2004);Lever, A. B. P.: Inorg. Chem., 29, 1271 (1990);Dawood, K., et. al.: Bioorg. Med. Chem., 14, 3672 (2006)<br></p>

<p>Stability Store in a Cool Dry Area.<br>Applications A metabolite of 1,4-diethenylbenzene.<br>References Linhart, I., et al.: Xenobiotica, 19, 645 (1989),<br></p>

<p>Applications 3-Methyl-1-(4-sulfophenyl)-2-pyrazolin-5-one acts as a reagent for the identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors. Ecto-5'-nucleotidase inhibition is thought to provide an attractive approach to cancer therapy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iqbal, J., et al.: Eur. J. Med. Chem., 70, 685 (2013)<br></p>

<p>Applications N-Benzylethanolamine is used in the synthesis of imidazoles as potent calcitonin (CGRP) antagonists. Also it aids in the preparation of benzofused hydroxamix acids, as useful fragments for the synthesis of histone deacetylase inhibitors.<br>References Tora, G. et al.: Bioorg. Med. Chem. Lett., 23, 5684 (2013); Marastoni, E. et al.: Bioorg. Med. Chem. Lett., 23, 4091 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tin (II) Chloride (in dilute solutions of HCl) is used as a reductant, and is utilized to prepare surfaces for electroless plating. Tin (II) Chloride is also used as a mordant in the textile industry because of its ability to form an insoluble precipitate with the dye, ultimately fixing it into the fiber. Tin (II) Chloride is also a reagent that is known to produce DNA damage in Chinese hamster ovary cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, R., et al.: J. Electrochem. Soc., 119, 433 (1972); Jothi, D.: Autex. Res. J., 8, 49 (2008); McLean, J., et al.: Mutat. Res. Lett., 119, 195 (1983);<br></p>

<p>Applications 3,3-Diphenylpropionic Acid is used in the preparation of steroid 5α-reductase inhibiting acylpiperidines. It can also be used in the preparation of calpain-inhibitory piptidyl α-ketoacids and esters.<br>References Picard, F. et al.: J. Med. Chem., 45, 3406 (2002); Donkor, I. et al.: J. Med. Chem., 51, 4346 (2008);<br></p>

<p>Applications Protected D-Glucitol.<br></p>

<p>Applications 1,1,1-Trimethoxybutane is used in the synthesis of angiotensin II receptor antagonists affecting blood pressure. Also used in the preparation of inhibitors of cyclin-dependant kinases.<br>References Yanagisawa, H. et al.: J. Med. Chem., 39, 323 (1996);<br></p>

<p>Applications (R)-RuCl[(p-cymene)(BINAP)]Cl is a ruthenium BINAP catalysts.<br>References Yue, C., et al.: Yingyong Huagong, 43, 1042 (2014); Bernas, H., et al.: Catal. Sci. Technol., 2, 1901 (2012)<br></p>

<p>Applications tert-ButylBrettPhos is a ligand commonly found on palladium catalysts used in the regioselective 2-amination of polychloropyrimidines.<br>References Smith, S.M., Buchwald, S.L., Org. Lett., 9, 2180-2183 (2016)<br></p>

<p>Applications Strontium Chloride Hexahydrate is used in the preparation of mesoporous strontium titanate thin films.<br>References Mohammadi, M. et al.: J. Coat. Tech. Res., 8, 585 (2011);<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).<br>References Takano, R. et al.: J. Carb. Chem., 14, 885 (1995); Rao, K. et al.: Synth. Comm., 37, 2275 (2007);<br></p>

<p>Applications Platinum chloride is a useful inorganic reagent which has been used in the preparation and characterization of Ru-Pt core-shell nanoparticles.<br>References Jin, S.; et al.: Yingyong Huaxue 35, 239 (2018).<br></p>

<p>Applications DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) (cas# 15529-49-4) is a useful research chemical.<br></p>

<p>Applications Benzeneruthenium(II) Chloride Dimer is a catalyst for SNAr reactions of fluoroarenes and cyclic amines, a precatalyst for the hydrogenation of β-keto esters and a precursor for the preparation of other ruthenium catalysts.<br></p>

<p>Applications Bariumhydroxidemonohydrate (cas# 22326-55-2) is a useful research chemical.<br></p>

<p>Applications Chloro(triethylphosphine)gold is an analogue of auranofin. Auranofin and its analogs show antimicrobial activity against multidrug-resistant pathogens<br>References Tizian M. et al.: Chem. Med. Chem. 13(22), 2448-2454 (2018)<br></p>

<p>Applications 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is an heterocyclic building block used in the synthesis of various chemical compounds.<br></p>

<p>Applications LITHIUM FLUORIDE (cas# 7789-24-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Potassium Peroxymonosulfate Sulfate is an extremely potent oxidizer. It also may act as a bactericidal agent as treatment of bacterial spores with this agent leads to damage to the spore’s inner membrane. Plays a role in oxidative halogenation of various carbonyl and ketone compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cortezzo, D. et al.: J. App. Microbio., 97, 838 (2004); Marri, M. et al.: Tetrahedron Lett., 52, 6554 (2011); Macharla, A. et al.: Tetrahedron Lett., 53, 191 (2012);<br></p>

<p>Applications 4-Amino-1-(diethylamino)pentane was used as a reagent in the synthesis of chromone-2-carboxamide derivatives which displayed cytotoxic activity against specific cancer cell lines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bousejra-ElGarah, F., et al.: Med. Chem. Res., 1054, pages ahead of print (2016);<br></p>

<p>Applications 1,5-Cyclooctadiene(pyridine)(tricyclohexylphosphine)iridium(I) Hexafluorophosphate is a catalyst that is used in the synthesis of 4α,5-Dihydro Simvastatin (D450010). 4α,5-Dihydro Simvastatin is an impurity in the synthesis of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>

<p>Applications 3-Bromo-2-methylbenzoic Acid is a disubstituted benzoic acid used in the preparation of various biologically active compounds such as α-2 adrenoceptor agonists, Smootherned receptor anatogonists and HIV-1 entry inhibitors.<br>References Stoilov, I. et al.: J. Hetercyc. Chem., 30, 1645 (1993); Katritzky, A. et al.: J. Med. Chem., 52, 7631 (2009); Pan, S. et al.: ACS Med. Chem. Lett., 1, 130 (2010);<br></p>

<p>Applications Mesitylcopper is an organometal used to synthesize compounds such as copper diketonate complexes.<br>References Larson, Alec. et al., Inorg. Chem. 59, 423-432(2020);<br></p>

<p>Stability Light Sensitive<br>Applications Butyl Nitrite is reagent used in the preparation of p-hydroxyphenylpyruvate dioxygenase inhibitors which has herbicidal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Witschel, M., Bioorg. Med. Chem., 17, 4221 (2009)<br></p>

<p>Applications DI-TERT-BUTYLSILANE (cas# 30736-07-3) is a useful research chemical.<br></p>

<p>Applications Benzyltributylammonium Bromide (cas# 25316-59-0) is a useful research chemical.<br></p>

<p>Applications Methyl α-bromophenylacetate is used in synthetic chemistry as an initiator for polymerization reactions (such as the polymerization of methyl methacrylate). Methyl α-bromophenylacetate is also used as a reagent to synthesize compounds that act as selective Serotonin (HCl: S274980) reuptake inhibitors (SSRI). SSRIs are used to modulate symptoms in autistic patients.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fors, B. &amp; Hawker, C.: Angew. Chem. Int. Edit., 51, 8850 (2012); Ghoneim, O., et al.: Bioorgan. Med. Chem. Lett., 21, 6714 (2011); O’Reilly, R., et al.: Macromolecules, 40, 7441 (2007)<br></p>

<p>Applications Dilithium Tetrachlorocuprate is an intermediate used in the synthesis of 10-Methylundecanol (M338110), an intermediate in the synthesis of Sulfobacin A;Also, it is derived from Lithium Chloride (L469105), which is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamiyama, T., et al.: J. Antibiot., 48, 924 (1995), Gupta, P., et al.: Tetrahedron Lett., 45, 9641 (2004); Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications Diisopropyl Azodicarboxylate is an azodicarboxylic acid derivative used as a reagent in the production of many organic compounds. Diisopropyl Azodicarboxylate is commonly used as an oxidizer in Mitsunobu reactions and can also serve as a selective deprotectant of N-benzyl groups in the presence of other protecting groups.<br>References Pichika, R. et al.: Nuc. Med. Biol., 38, 1183 (2011); Kroutil, J. et al.: Synthesis, 3, 446 (2004); Hughes, D.L. et al.: Org. React., 42, 335 (1992);<br></p>

<p>Applications Tetrakis(acetonitrile)palladium Bis(tetrafluoroborate) is used to prepare an α-Diimine-transition metal complex, which is used as a catalyst for polymerization of olefins. It is also a catalyst used in cross coupling reaction for C-C, C-O, and C-N bond formation.<br>References Feldman, J., et al.: Organometallics, 16, 1514 (1997); Johnson, L., et al.: PCT Int. Appl., WO 9623010 A2 19960801 (1996); Poppenbery, J., et al.: Surface Sci., 2011; Pijnenburg, N., et al.: Dalton Transactions, 40, 8896 (2011); Kilpin, K., et al.: Inorg. Chem., 50, 6334 (2011)<br></p>

<p>Applications [1,2-Bis(diphenylphosphino)ethane]dichloropalladium(II) is a precatalyst used in the production of acrylic acid sodium salt via coupling of CO2 with ethene.<br>References Vavasori, A.; et al.: Pure Appl. Chem., 90, 315 (2018).<br></p>

<p>Applications Copper(I) Chloride, has many applications. The main use of copper(I) Chloride is as a precursor to the fungicide copper oxychloride. In organic synthesis, CuCl is used as an initiator of radical reactions such as the hydrostannation of α,β-unsaturated ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wade, L. G., et al.: Org. Chem., 5th Ed., 871 (2003); Ooi, T., et al.: Tetrahedron Lett., 40, 2133 (1999);<br></p>

<p>Applications Zinc Bromide is used as a catalyst in the synthesis of tetrazoles which exhibit antibacterial activity in vitro. Zinc Bromide is also a zinc salt that is added as a nutritional or functional ingredient in food and oral care products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cui, J., et al.: Xiandai Shengwuyixue Jinzhan, 12, 3478 (2012); Keast, R.S.J.: J. Food Sci., 68, 1871 (2003)<br></p>

<p>Applications [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II), is a palladium catalyst used in chemical synthesis of various compounds.<br></p>

<p>Applications Isobutyl Acetoacetate is a building block that has been used as a reactant in the preparation of b-annulated 1,4-dihydropyridine derivatives as TGFβ signaling inhibitors.<br>References Schade, D., et. al.: J. Med. Chem., 55, 9946 (2012)<br></p>

<p>Applications Osmium Tetroxide (4% in H2O) is a reagent that is used in the dihydroxylation process in the synthesis of 3-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]-1,2-propanediol (D436535). 3-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]-1,2-propanediol is involved in biological studies as microsomal cytochrome P 450 isoenzymes from Penicillium italicum interaction with sterol demethylation inhibitor fungicides.<br>References Guan, J., et al.: Pest. Biochem. Physiol., 42, 24 (1992);<br></p>

<p>Applications Tris(trimethylsilyl)silane) is used in the synthesis of silated alkenes and alkynes. Also used in the preparation of fused quinolines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kopping, B.et al.: J. Org. Chem., 57, 3994 (1992); Du, W. et al.: Org. Lett., 5, 1765 (2003);<br></p>

<p>Applications Intermediate of 4-Hydroxydebrisoquine. S-Methyl-isothiouronium Hemisulfate is also a reagent used in the synthesis of strobilurin-pyrimidine derivatives for their anti-proliferative activity.<br>References Young, R.C., et al.: J. Med. Chem., 31, 670 (1988); Chai, B. et al.: Bioorg. Med. Chem. Lett., 23, 3505 (2013);<br></p>

<p>Applications n-Butyltriphenylphosphonium Bromide is used in the synthesis of inhibitors of tubulin polymerization thus expressing antimitotic and antitubulin properties. Also used in the synthesis of 3-phenylpropanoic acids as peroxisome proliferator-activated receptor dual agonists affecting the mitochondrial carnitine system.<br>References Cushman, M. et al.: J. Med. Chem., 38, 2041 (1995); Laghezza, A. et al.: J. Med. Chem., 56, 60 (2013);<br></p>

<p>Applications Di-O-acetyl-L-tartaric Anhydride (cas# 6283-74-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Bromoindoline is a brominated indoline derivative and a product of biocatalyzed halogenation of nucleobase analogs. 5-Bromoindoline is used in the synthetic preparation of biologically active compounds such as selective human β3 adrenergic receptor agonists.<br>References Mathvink, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 1869 (1999); Medici, R. et al.: Biotechnol. Lett., 33, 1999 (2011);<br></p>

<p>Applications Sodium Hydrogen Sulfate is used in production of Nickel Hydroxide Electrode material for Alkaline battery.<br>References Naboka, O., et al.: Eur. Pat. Appl., (2020);<br></p>

<p>Applications Chlorodifluoro-acetic Acid Sodium Salt (cas# 1895-39-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Pyrrole-1-carboxylic Acid tert-Butyl Ester is an intermediate in the synthesis of pyrrole derived anti-cancer Agent.<br>References Ondachi, P.W., et al.: J. Med. Chem., 57, 836 (2014); You, H., et al.: Euro. J. Med. Chem., 46, 1153 (2011);<br></p>

<p>Applications 1,1'-(AZODICARBONYL)DIPIPERIDINE (cas# 10465-81-3) is a useful research chemical.<br></p>

<p>Applications Cyclohexanecarbonyl Chloride is used to prepare 1,2,3-triazoles as inhibitors of human immunodeficiency virus type 1 protease. It was also used to synthesize benzothiazole as potent antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Whiting, M., et al.: J. Med. Chem., 49, 7697 (2006); Yoshida, M., et al.: Bioorg. Med. Chem. Lett., 15, 3328 (2005)<br></p>

<p>Applications 4-Oxocyclohexanecarboxylic Acid is used in the preparation of Indomethacin (I641000) analogues used in the treatment of prostate cancer. In addition it is used in the synthesis of β-alanine derivatives as glucagon receptor antagonists.<br>References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Lau, J. et al.: J. Med. Chem., 50, 113 (2007);<br></p>

<p>Stability Very Moisture sensitive<br>Applications (R)-(+)-α-Methylbenzyl isocyanate is used in the synthesis of non-steroidal mineralocorticoid receptor antagonists. Also used in the synthesis of antiviral and anti-HIV agents such as DPC 961.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, C. et al.: ACS Med. Chem. Lett., 6, 461 (2015); Andrushko, V. (2013). Stereoselective Synthesis of Drugs and Natural Products. Hoboken, NJ: John WIley &amp; Sons.<br></p>

<p>Applications 4-Chloro-3-nitrophenol is degraded by Burkholderia sp. strain SJ98 and utilizes it as sole source of carbon, nitrogen and energy under aerobic conditions. Also it is an intermediate of 8-Hydroxychlorpromazine (H824905), which is a metabolite of chlorpromazine (C424750) which is used as an antiemetic.<br>References Pandey, J., et al.: Appl. Microbiol. Biotechnol., 92, 597-607 (2011); Roth, J., et al.: Comm. Psychopharmacol., 3, 235 (1979); Zhang, Z.: Handbook of Metabolic Pathways of Xenobiotics, 3, 1102 (2014); Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990)<br></p>

<p>Applications Phenylselenyl Bromide is used as a reagent in the synthesis of the antihyperglycemic agent, (+)-Antroquinonol. Phenylselenyl Bromide is also used in the preparation of 9-epi-Artemisinin (A777505); the chiral isomer of Artemisinin (A777500) which is an antimalarial.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sulake, R.S., et al.: J. Org. Chem., 80, 6044 (2015); Orabi, K.Y. et al.: Phytochem., 51, 257 (1999); Jefford, C.W. et al.: Helv. Chim. Acta, 83, 1239 (2000); Klayman, D.L., et al.: Science, 228, 1049 (1985)<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Nitrobenzyl Chloroformate is used in the preparation of prodrugs of cytotoxic acridines used in conjunction with enzyme prodrugs which counter carcinoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asche, C. et al.: Bioorg. Med. Chem. Lett., 16, 1990 (2006); Hay, M. et al.: J. Med. Chem., 46, 2546 (2003);<br></p>

<p>Stability Moisture Sensitive<br>Applications Aluminum Trichloride is a powerful chemical reagent used as a catalyst in Freidel Crafts reactions, alkylations and acylations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Groggins. P. et al.: Ind. Eng. Chem., 23, 152 (1931); Brown, H. et al.L J. Am. Chem. Soc., 80, 2291 (1958);<br></p>

<p>Applications Iron(III) Bromide is used in the production of new disinfectant and in the study of it’s antimicrobial activity, improved synthesis of neotame, an artificial sweetner.<br>References Gluzman, M. K., et al.: Farmatsevtichnii Zhurnal, 24, 37 (1969); Yan, R., et al.: From Shipin Kexue (Beijing, China) (2008), 29(12), 312-315<br></p>

<p>Applications A structural homologue of the natural polyamine spermidine with antitumor activity that may make it useful as a antineoplastic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prakash, N. et al.: Anticancer Res., 8, 563 (1988); Sunkara, P.S. et al.: Adv. Exp. Med. Biol., 250, 707 (1988); Porter, C.W. et al.: Cancer. Res., 42, 4072 (1982);<br></p>

<p>Applications 3-Bromopyridine-d4 is the isotope labelled analog of 3-Bromopyridine (B686740). Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),<br></p>

<p>Applications 3-Hexyn-1-ol is an unsaturated alcohol that, when subjected to stereoselective hydrogenation, produces cis-3-Hexen-1-ol (H295005), a compound that is important in the fragrance industry. 3-Hexyn-1-ol also exhibits antifungal properties against Aspergillus oryzae, a fungus that is used to produce fermented foods and beverages in Japan.<br>References Machida, M., et al.: Nature, 438, 1157 (2005); Sachse, A., et al.: Dalt. Trans., 42, 1378 (2013); Witte, P., et al.: Stud. Surf. Sci. Catal., 175, 135 (2010)<br></p>