Ácidos y reactivos sintéticos

<p>Applications Dichlorobis(triphenylphosphine) Palladium (II) is used primarily in organometallic catalytic reactions due to the palladium content of the compound. It is also involved in crystalized structures of metallacyclic complexes which show antiinflammatory and antifungal properties.<br>References Paul, P. et al.: J. Organometal. Chem., 724, 281 (2013); Pandiarajan, D. et al.: J. Organometal. Chem., 708-709, 18, (2012); Shhaheen, F. et al.: J. Organometal. Chem., 693, 315 (2010);<br></p>

<p>Applications (S)-4-(prop-1-En-2-yl)cyclohex-1-enecarbaldehyde (cas# 18031-40-8) is a useful research chemical. A possible biomarker of Parkinson’s disease.<br>References Drupad, K. T., et al.: ACS Central Science, (2019)<br></p>

<p>Applications 2-Chloro-4-fluorobenzoic Acid s a useful synthetic intermediate. It can be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. It can also be used to synthesize (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists.<br>References Barnett, H., et al.: Bioorg. Med. Chem. Lett., 19, 158 (2009); Tsukamoto, I., et al.: Bioog. Med. Chem., 16, 9524 (2008)<br></p>

<p>Applications 2-(2-Boc-aminoethoxy)ethanol is a reactant that has been used in the synthesis of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, X., et. al.: Molecules, 18, 13957 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.<br>References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),<br></p>

<p>Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.<br>References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);<br></p>

<p>Applications The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3ß inhibitor (IC50=23nM).<br>References Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999), Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001), Bain, J., et al.: Biochem. J., in press.<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Applications Lithium hydroxide is a reagent that is used in the synthesis of O-Desmethyl Mebeverine Acid O-β-D-Glucuronide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Calcium Hypochlorite is a general chemical reagent used in the preparation of deicing salt. As well used as a disinfecting agent for pools as well as a disinfecting additive for dental stone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Farnam, Y. et al.: Cement Conc. Comp., 64, 1 (2015); Twomey, J. et al.: J. Prosthet. Dent., 90, 282 (2003);<br></p>

<p>Applications 4-Methoxybenzenemethanamine is used in the synthesis of COX2 inhibitors based on a pyrimidine scaffold. Also used in the preparation of SIRT1 inhibitors. Used in anti-cancer treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tietz, O. et al.: Org. Biomol. Chem., Eur. J. Med. Chem., 69, 125 (2013);<br></p>

<p>Applications (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.<br>References Agouridas, C., et al.: J. Med. Chem., 41, 4080 (1998);<br></p>

<p>Applications LY 2874455 is a pan-FGFR inhibitor which remain the focus of research for use in lung and bladder cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gozgit, J. et al.: Mol. Cancer Ther., 11, 690 (2012); Zhao, G. et al.: Mol. Cancer Ther., 10, 2200 (2011);<br></p>

<p>Applications 1,2-Dibromo-4,5-dimethylbenzene is used as a reagent in the synthesis of Thalidomide (T338850); an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Also a teratogenic sedative and immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.<br>References Chen, J., et al.: Org. Biomol. Chem., 12, 5578 (2014); D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994); Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993); Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>

<p>Applications (S)-(+)-Benzyl Glycidyl Ether is used as a reactant in the synthesis of (+)-Discodermolide.<br>References Smith, A.B. et al.: J. Am. Chem. Soc., 122, 8654 (2000);<br></p>

<p>Stability Light Sensitive<br>Applications (S)-β-Pinene is a monoterpene that naturally occur in various plants. Due to its pine-like smell, its been used as a major constituent of hop aroma and flavor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Jingyi., et la.: J. Neurochem., 121, 881 (2012); Wu, J., et al.: J. Med. Plants. Res., 6, 2832 (2012);<br></p>

<p>Applications Tetrapropylammonium bromide (cas# 1941-30-6) is a useful research chemical.<br></p>

<p>Applications (S)-(-)-Alpha-Methoxy-Alpha-(Trifluoromethyl)Phenylacetic Acid (cas# 17257-71-5) is a useful research chemical.<br></p>

<p>Applications 3-Phenylpropyne is a useful synthetic intermediate. It is an intermediate used to synthesize carlina oxide. It can also be used to prepare triazole substituted pyrazolopyrimidinamide derivatives via click chemistry as potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klein, M., et al.: Org. Biomol. Chem., 7, 3421 (2009)<br></p>

<p>Stability Very Hygroscopic<br>Applications Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).<br>References (1) Klamer, D., et al.: Eur. J. Pharmacol. (2004) 503: 103-107(2) Marletta, M.A.: J. Med. Chem., 37(13), 1899 (1994)(3) Zhang, H.Q., et al.: J. Med. Chem., 40, 3869 (1997)<br></p>

<p>Applications Tin(II) trifluoromethanesulfonate (cas# 62086-04-8) is a useful research chemical.<br></p>

<p>Applications 2,3-Dichloroquinoxaline is a dichlorinated quinoxaline derivative with antimicrobial activity. 2,3-Dichloroquinoxaline is used in the preparation of quinoxaline derivatives of cancer chemopreventive activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metzner, J. et al.: Pharmazie, 36, 368 (1981); Galal, S.A&gt; et al.: Eur. J. Med. Chem., 46, 327 (2011);<br></p>

<p>Applications Sodium Perborate Tetrahydrate acts as a bleaching agent using oxygen causing less degradation to dyes and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murray, L. et al.: J. Am. Oil Chem. Soc., 45, 493 (1968);<br></p>

<p>Applications 2-Bromophenylacetic Acid is used as the starting material in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630); a degredation product of Asenapine (A788000) which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist structurally related to Mianserin (M341500, HCl). Also used as an antipsychotic.<br>References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A., et al.: Brain Res., 631, 191 (1993); Andree, B., et al.: Psychopharmacology, 131, 339 (1997); Richelson, E., et al.: Life Sci., 68, 29 (2000)<br></p>

<p>Applications Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.<br>References Kuntzman, R., et al.: Clin. Pharmacol. Ther., 11, 829 (1970), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Carter, J.E., et al.: Anal. Profiles Drug Subs., 9, 71 (1980),<br></p>

<p>Applications Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.<br>References Shao, J., et al.: Shiyong Yixue Zazhi, 31, 4143 (2015); Gerstner, E. R., et al.: Transl. Cancer Res., 5, 211 (2016)<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethylenediamine Hydrochloride is a reagent used to synthesize new opioid ligand as an analgesics with mixed agonist and antagonist properties to induce tolerance and dependence.<br>References Salvadori, S., et al.: Bioorg. Med. Chem., 15, 6876-6881 (2007);<br></p>

<p>Applications Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.<br></p>

<p>Applications (R)-tert-Butyl 2-hydroxypropanoate is an intermediate used in the stereo controlled synthesis of hydroxy carboxylic acids from L-amino acids.<br>References Kunz, H., et al.: Tetrahedron Lett., 28, 1873 (1987)<br></p>

<p>Applications 4-Fluoro-3-nitrobenzenesulfonyl chloride is a used in the preparation of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.<br>References Zhou, Haibin., et al.: J. Med. Chem., 55, 6149 (2012);<br></p>

<p>Applications 4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hardtmann, G.E. et al.: J. Med. Chem., 18, 447 (1975); Bartl, V. et al.: Coll. Czechoslov. Chem. Comm., 45, 3182 (1980);<br></p>

<p>Applications CUR 61414 is a proline derivative as mediator of hedgehog signaling pathways for pharmaceutical and cosmetic uses. CUR 61414 is a Nucleoside analog. CUR 61414 is an antimetabolite antitumor combination Gemcitabine cancer treatment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Van der Riet, P., et al.: Cancer Res., 54, 25 (1994), Hahn, H., et al.: Cell, 85, 841 (1996), Johnson, R., et al.: Science, 272, 1668 (1996), Ingham, P., et al.: Genes Dev., 15, 3059 (2001),<br></p>

<p>Applications Ethyl Succinoyl Chloride, used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012);<br></p>

<p>Applications Bismuth Citrate is a reagent used in the preparation of nano-array wires and nanotubes. Also used in the preparation of collidal bismuth subcitrate with ulcer healing properties.<br>References Chen, R. et al.: Chem. Commun (Camb)., 21, 2265 (2006); Asato, E. et al.: Inorg. Chem., 34, 2447 (1995);<br></p>

<p>Applications 4-Chlorophenyl Isocyanate, is an intermediate used for the synthesis of novel pyrimido[5,4-c]quinolin-4(3H)-one derivatives, having antibacterial and antifungal activities. It is also shown to have anti tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Yu., et al.: Youji Huaxue, 33(5), 1074 (2013); Moos, G. E., et al.: Cancer Res., 31(7), 937 (1971);<br></p>

<p>Applications 1,3-Diiodopropane is a useful research chemical. A reagent used in the preparation of synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial properties.<br>References Ellis, G. L., et al.: Bioorg. Med. Chem. Lett., 18, 1720 (2008)<br></p>

<p>Applications An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.<br>References Senderowicz, A.M., et al.: J. Clin. Oncol., 16, 2986 (1998), Thomas, J.P., et al.: Cancer Chemother. Pharmacol., 50, 465 (2002), Raju, U., et al.: Cancer Res., 63, 3263 (2003), Pumfery, A., et al.: Curr. Pharm. Des., 12, 1949 (2006),<br></p>

<p>Applications BDP 37 is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4). It is also an ampakine drug that facilitates activation of glutamatergic AMPA receptors.<br>References (1) Arai, A., et al.: J. Pharmacol. Exp. Ther., 278, 627 (1996)(2) Marini, A., et al.: J. Biol. Chem., 273, 29394 (1998)(3) Balkowiec, A., et al.: J. Neurosci., 22, 10399 (2002) (4) Dicou, E., et al.: Brain Res., 970, 221 (2003)<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications 1,4-Dichloro-2-butyne used in the synthesis of 1,4-disubstituted 1,2,3-triazoles. Also, it is used in the approach of the 20S-camptothecin family of antitumor agents.<br>References Feldman, A. et al.: Org. Lett., 6, 3897 (2004); Josien, H. et al.: Chem. Eur. J., 4, 67 (1998);<br></p>

<p>Applications 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression<br>References Qian, F., et al.: Cancer Immunology Immunothrapy, 61, 2013 (2012)<br></p>

<p>Applications α-Phenyllongifolol is an impurity in the synthesis of Longifolene (L469455) which is a constituent of black cumin seed and may exhibit anticancer and antibacterial activities.<br>References Hajhashemi, V., et al.: Phytother. Res 18, 195 (2004); Bourgou, S., et al.: S Afr J Bot 76, 210 (2010)<br></p>

<p>Applications A useful intermediate in the synthesis of polypeptides.<br></p>

<p>Applications 2-Amino-4-methylphenylboronic acid, pinacol ester<br></p>

<p>Applications Ethynyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Freidreich’s ataxia. It also aids in the preparation of conjugated polymers with sn anthracene backbone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, C. et al.: Pharmaceu. 4, 1578 (2011); Kobayashi, E. et al.: J. Polym. Sci. Part A: Polym. Chem., 28, 2641 (1990);<br></p>

<p>Applications Guanadine thiocyanate is a strong protein denaturant. It is used as a chaotropic agent for the isolation of intact RNA during the process of cell lysis. It shows strong irreversible inhibition on enveloped viruses. It is a key chemical used to isolate the virus’ genetic material, or RNA so that it can be tested.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.<br>References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);<br></p>

<p>Applications An amide analog of Eugenol, and is used therapeutically as an antispasmodic.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 14, 6502 (2006),<br></p>

<p>Applications 4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones.<br>References Perez-Cruz, F. et al.: Bioorg Med. Chem. Lett., 22, 5569 (2012); Liu, H. et al.: J. Mol. Cata. A. Chem., 244, 68 (2006);<br></p>

<p>Applications 4-(Bromomethyl)benzoic Acid Methyl Ester is an ester derivative of a bromoalkylated benzoic acid. 4-(Bromomethyl)benzoic Acid Methyl Ester is used in the preparation of potential anti-HIV agents. It is also used as a catalyst for rearrangement of benzylthiothiazoline derivatives in the preparation aldose reductase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, M. et al.: Bioorg. Med. Chem. Lett., 8, 833 (1998); Nagao, Y. et al.: Chem. Pharmac. Bull., 36, 509 (1988);<br></p>

<p>Applications Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles.<br>References Harrington, M. et al.: Eur. J. Clin. Nutr., 65, 20 (2011); Takasawa, K. et al.: Nutrients, 7, 103 (2015);<br></p>

<p>Applications Tocainide Hydrochloride is used as an anti-arrythmic drug as myocardial depressants.<br>References Courtney, K. et al. J. Molec. Cell. Cardiol., 12, 1273 (1980); Kwok, D. et al.: Res. Comm. Chem. Path. Pharm., 67, 395 (1990);<br></p>

<p>Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.<br>References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications N-Boc-6-hydroxyhexylamine (cas# 75937-12-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Calcium Sulfate Dihydrate is obtained from gypsum, a naturally occurring compound. Also used in the preparation of calcium sulfate and calcium sulfoaluminate.<br>References Strydom, C. et al.: J. Therm. Anal., 49, 1501 (1997); Winnefeld, F. et al.: DGCh-Monograph., 44, 30 (2011);<br></p>

<p>Applications Mercury(II) acetate is a reagent that is used in the investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prevost, M., et al.: J. Org. Chem. 79, 10504 (2014);<br></p>

<p>Applications 5-(Trifluoromethyl)picolinic Acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.<br>References Tresadern, G., et al.: Bioorg. Med. Chem. Lett., 21, 7255 (2011); Watanabe, T., et al.: Bioorg. Med. Chem., 20, 5839 (2010);<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications Benzenesulfonyl Chloride is used in the synthesis of cecloprotoberberine derivatives as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Y. et al.: Eur. J. Med. Chem., 68, 463 (2013);<br></p>