Ácidos y reactivos sintéticos

<p>Applications (3-Glycidoxypropyl)triethoxysilane is used in the fabric industry to treat and modify fabrics.<br>References Schramm, Christian, et al.: Coloration Tech., 133(3), 234-242 (2017);Grancaric, Ana Marija, et al.: Pro. in Org. Coatings, 103, 174-181 (2017); Yeo, Jun-Seok, et al.: J. of Ind. and Eng. Chem., 45, 301-306 (2017)<br></p>

<p>Applications Tetrabutylammonium Bromide is used in the synthesis of polymer solar cells. Also used in the synthesis of single component green-light emitting electrochemical cells.<br>References Yun, H. et al.: Chem. A Eur. J., 19, 13242 (2013); Sun, M. et al.: J. Disp. Tech., 9, 476 (2013);<br></p>

<p>Applications Barium hydroxide octahydrate is a reagent that is used in solid state metathesis of rocksalt oxides for synthesis of perovskite oxides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandal, T. K., et al.: J. Mat. Chem., 14, 1273 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications EDDHA is used as an inorganic fertilizer.<br>References Kalantari, S.et al.: Comm. Soil Sci. Plant Anal., 42, 123 (2011); Albano, J. et al.: HortSci., 47, 269 (2012);<br></p>

<p>Applications TG101348 is a selective inhibitor of JAK2 tyrosine kinase. Potent JAK2 inhibitor.<br>References Rosenthal, A., et al.: Expert Opin. Pharmacotherapy, 15, 1265 (2014); Geyer, H.L., et al.: Hematol., 17, s129 (2012); Zhou, T. et al.: Leukemia, 28, 404 (2014)<br></p>

<p>Applications Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.<br>References Conte, L. A.: U.S. Pat. Appl. Publ. (2020), US 20200345687 A1<br></p>

<p>Stability Hygroscopic<br>Applications 1,4-Pentanediol is a useful synthetic intermediate. It was used in the preparation of poly(ortho ester). 1,4-Pentanediol on dehydration in water at 573K yields five-membered ether, 2-methyltetrahydrofuran.<br>References Heller, J., et al.: J. Controlled Release, 78, 133 (2002); Yamaguchi, A., et al.: green Chem., 11, 48 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications Sodium Sulfide Nonahydrate is used as a reagent in the synthesis of surface functionalized cadmium sulfide quantum dots.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Veinot, J.G.C., et al.: Chem. Mater., 9, 2117 (1997)<br></p>

<p>Applications Dimethyl Aminoterephthalate is used to prepare imidazotetrazinones as probes for action of temozolomide. It can be used to prepare aminoquinazolines with neurokinin-2 receptor antagonist activity.<br>References Clark, A., et al.: J. Med. Chem., 38, 1493 (1995); Jacobs, R., et al.: Bioorg. Med. Chem. Lett., 5, 2879 (1995)<br></p>

<p>Applications Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.<br>References Emuebie, O. et al: Aus. J. Basic App. Sci., 5, 507 (2011); Cambal, L. et al.: Chem. Res. Toxicol., 24, 1104 (2011); Lam, X. et al.: J. Pharm. Sci., 86, 1250 (1997);<br></p>

<p>Applications SRT1720 acts as a therapeutic in the treatment of type 2 diabetes. It modulates calories and contributes to glucose homeostasis and insulin sensitivity.<br>References Milne, J. et al.: Nature, 450, 712 (2007);<br></p>

<p>Applications 3-(2-Hydroxyphenyl)Propionic Acid (cas# 495-78-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A deuterated selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),<br></p>

<p>Applications Shows antiulcer activity in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Uchida, M., et al.: Chem. Pharm. Bull., 33, 3775 (1985), Yamasaki, K., et al.: Eur. J. Pharmacol., 142, 23 (1987),<br></p>

<p>Applications Anticholinergic.<br>References Umetzu, T., et al.: Eur. J. Pharmacol., 64, 69 (1980),<br></p>

<p>Applications Sodium Borohydride is used as a reagent in the reduction of amino acids and their derivatives. Also used in the catalysis of ammonia borane dehydrogenation.<br> E0<br>References McKennon, M. et al.: J. Org. Chem., 58, 3568 (1993); Denney, M. et al.: J. Am. Chem. Soc., 128, 12048 (2006);<br></p>

<p>Applications Trimethoxy(octyl)silane is a surface modifier used as additive for polymer encapsulation and for controlled drug delivery.<br>References Erdem, B., et al.: Langmuir, 17, 2664 (2001); Doadrio, J., et al.: J. Mater. Chem., 16, 462 (2006);<br></p>

<p>Applications Sodium Pyrophosphate has been shown to enhance the rate of pyrophosphate hydrolysis by nonenzymatic catlysis and by inorganic pyrophoshatase. Pyrophosphoric Acid can be used for the preparation of vanadyl pyrophosphato methoxide cluster anion. Pyrophosphoric Acid is used in anion binding of inorganic phosphates due to is ability to form complexes.<br>References Stockbridge, R. B., Wolfenden, R.: J. Biol. Chem., 286, 18538 (2011); Herron, N., et. al.: J. AM. Chem. Soc., 119, 7149 (1997); Nation, D., et. al.: Inorg. Chem., 35, 4597 (1996)<br></p>

<p>Applications GSK360A orally active HIF-PHD inhibitor. GSK360A exerts systemic and local effects by stabilizing HIF-1α signaling and improves long-term ventricular function, remodeling, and vascularity in a model of established ventricular dysfunction. These findings suggest that GSK360A may be suitable for the treatment of post-MI remodeling and heart failure.<br>References Bao, W.-K. et al.: J. Cardio. Pharmacol., 56, 147 (2010);<br></p>

<p>Applications Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-binding inhibitor of Eg5 that prevents mitotic progression.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References DeBonis, S. et al.: J. Med. Chem., 51, 1115 (2008); Chadwick, D.J. et al.: J. Chem. Soc. Perk. Trans. Org. Bio-Org. Chem., 1, 102 (1983);<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.<br>References Levy, Harvey L., et al.: Lancet,  370, 504 (2007); Isojima, Yasushi., et al.: Proc Natl Acad Sci USA .,106, 15744 (2009); Burton, B. K., et al.: J. Inherit. Metab. Dis., 30, 700 (2007)<br></p>

<p>Stability Hygroscopic<br>Applications Sodium hexacyanoferrate(II) decahydrate is being used and studied as a possible cathode material for sodium ion batteries.<br>References Piernas-Munoz, J.M., et al.: Electrochim. Acta., 200, 123-30 (2016);<br></p>

<p>Applications Zaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.<br>References Hirate, K., et al.: Nerosci. Res., 54, 288 (2006); Yamamoto, M., et al.: Chirality, 2, 280 (1990); Inoue, M., et al.: J Pharmacol. Exp. Ther., 293, 662 (2000); Graven-Nielsen, T., et al.: Clin. J. Pain, 17, 2 (2001)<br></p>

<p>Applications Antilipemic.<br>References Fuccella, L.M., et al.: Clin. Pharmacol. Ther., 28, 790 (1980), Lovisolo, P.P., et al.: Pharmacol. Res. Commun., 13, 151 (1981), Aktories, K., et al.: Arzneim.-Forsch., 33, 1525 (1983), Boatman, P., et al.: J. Med. Chem., 51, 7653 (2008), Rigazio, S., et al.: Am. J. Physiol., 295, E413 (2008),<br></p>

<p>Applications 3-Mercaptopropionic Acid (cas# 107-96-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Lead(II) Nitrate, is toxic, an oxidising agent, and is categorized as probably carcinogenic to humans . It is shown to inhibit bacterial oxidation of ferrous iron in sulfate-rich systems. Other Lead(II) Nitrate applications include use as a heat stabilizer in nylon and polyesters, as a coating for photothermographic paper, and in rodenticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hongmei, w., et al.: J Hazard. Mat., 244, 718 (2013); Greenwoos, N. N., et al.: 388 (1997); Pauley, J. L., et al.: J. Amer. Chem. Soci., 76 (16), 4220 (1954);<br></p>

<p>Applications (-)-Perillyl Alcohol is a monoterpene that induces apoptosis in colon tumor cells. Also, it is used in preparation of terpene-vanilloid conjugates as anti-inflammatory agents.<br>References Young, Sherri C., et al.: U.S. Pat. Appl. Publ., (2020);<br></p>

<p>Impurity Flucytosine EP Impurity A<br>Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);<br></p>

<p>Applications Ulipristal acetate is a selective progesterone receptor modulator. Ulipristal acetate is used during pregnancy.<br>References Gronemeijer, H., et al.: J. Steroid Biochem., 40, 271 (1991), Spitz, I., et al.: Contraception, 48, 403 (1993), Conneely, O., et al.: Steroids, 68, 771 (2003), Chwalisz, K., et al.: Endocr. Rev., 26, 423 (2005),<br></p>

<p>Applications Bromochloroacetic acid is a halogenated disinfection byproduct commonly found in drinking water, fruit juice, and cheese. Bromochloroacetic acid has been shown to cause mesothelioma, fibroadenomas, and adenomas in rats<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hang, C., et al.: Sci Total Environ. 543, 425 (2016); Cardador, M. J. and Gallego, M.: Food Chem. 173, 685 (2015); Natl Toxicol Program Tech Rep Ser. 549, 1 (2009)<br></p>

<p>Applications Protected 1,2-Phenyldiamine, an intermediate in the synthesis of histone deacetylase agents and antitumor agents.<br>References Andrews, D., et al.: Bioorg. Med. Chem. Lett., 18, 2580 (2008), Mahboobi, S., et al.: J. Med. Chem., 52, 2265 (2009),<br></p>

<p>Applications A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.<br>References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),<br></p>

<p>Applications 1-(Bromomethyl)-2-nitrobenzene is a reagent used in the synthesis of 1,3,4-oxadiazole derivatives possessing a benzotriazole moiety leading to anticancer activity. Also used in the preparation of antifungal triazole derivatives.<br>References Zhang, S. et al.: Bioorg. Med. Chem., 21, 3723 (2013); Yu, S. et al.: Arch. Pharm. Res., 36, 1215 (2013);<br></p>

<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>

<p>Applications Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications (R,R)-Labetalol Hydrochloride is a specific competitive antagonist at both α-and β-adrenergic receptor sites. (R,R)-Labetalol Hydrochloride is also used as an antihypertensive.<br>References Sybertz, E.J., et al.: J. Pharmacol. Exp. Ther., 218, 435 (1981), Clifton, J.E., et al.: J. Med. Chem., 25, 670 (1982), Goa, K.L., et al.: Drugs, 37, 583 (1989),<br></p>

<p>Applications 2-​Methoxy-​4-​methylphenol is used in treating inflammatory disorder, by inhibiting IL-6 expression and other expressions and activating nirp3 inflammasome in cells. Also used as one of the substances for the mechanism-based QSAR modelling of skin sensitization.<br>References Ka, Shuk M., et al.: Taiwan. (2015), TW I498114 B 20150901, Dearden, J. C., et al.: Chem. Res. Toxicol., 28, 1975 (2015)<br></p>

<p>Applications 2-Chloroethyl isocyanate is used as a reagent and building block in chemical synthesis. In particular, it is used in the preparation of functionalized aminobenzoboroxoles which are potential anti-cancer agents and also the synthesis of 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one which also exhibit antiproliferative activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suman, P., et al.: J. Organomet. Chem., Ahead of Print (2015); Maggio, B., et al.: Eur. J. Med. Chem., 96, 98 (2015)<br></p>

<p>Applications Used in the one-pot synthesis of 2-aminobenzimidazoles.<br>References Artman, G.D., et al.: Tetrahedron Lett., 51, 5319 (2010),<br></p>

<p>Applications Mercury(II) Chloride is used to produce amalgamated aluminium which is used as reducing agent. Mercury(II) Chloride is also used as a catalyst for the conversion of acetylene to vinyl chloride.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diuguid, L., et al.: J. Am. Chem. Soc., 12,3527 (1941);<br></p>

<p>Applications Used for preparation of hydrophilic polymers for biomedical devices.<br>References Delbressine, L., et al.: Xenobiotica, 11, 241 (1981), Gerberick, G., et al.: Toxicol. Sci., 97, 417 (2007),<br></p>

<p>Stability Very Hygroscopic<br>Applications Potassium trifluoroacetate (cas# 2923-16-2) is a useful research chemical.<br></p>

<p>Applications o-Acetyltoluene can be used as a reagent to prepare diaryl dihydropyrazoles as inhibitors of mitotic kinesin spindle protein (1). It is also used to synthesize aryl- and indolyl-cyanoaminopyridines with anti-inflammatory, analgesic, and antipyretic activities (2).<br>References (1) Cox, C., et al.: Bioorg. Med. Chem. Lett. (2005) 15, 2041 (2) Manna, F., et al.: Eur. J. Med. Chem. (1999) 34, 245-54<br></p>

<p>Applications 5-Carboxyfluorescein is a useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derives reagent. Dyes and metabolites.<br>References Theisen, P., et al.: Tetrahedron Lett., 33, 5033 (1992); Mattingly, P.: Bioconjgate Chem., 3, 430 (1992); Bertrand, R., et al.: Biochemistry, 34, 9500 (1995);<br></p>

<p>Applications Sodium Iodide is used in the synthesis of dye-sensitized solar cells. Also used in the preparation of propargylamines as inhibitors of lysine specific. demethylase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zalas, M. et al.: Electrochem. Acta., 108, 736 (2013); Schmitt, M. et al.: J. Med. Chem., 56, 7334 (2013);<br></p>

<p>Applications (R)-(-)-2-Amino-1-butanol (cas# 5856-63-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Zinc Nitrate Hexahydrate is a component used in the composition for nourishing and protecting fruit trees from acid rain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blankson, H., et al.: J. Nutr., 130, 2943 (2000), Won, J., et al.: J. Food Sci., 73, N39 (2008),<br></p>

<p>Applications Indigopurpurin is a purple 3,2-bisindole derivative and was shown to exhibit inhibitory allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. A possible glycogen synthase kinase-3 (GSK-3) inhibitor the active component of a traditional Congolese antiepilepsy treatment.<br>References Kim, M.H., et al.: J. Ethnopharmacol., 145, 214 (2013); Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Hsieh, W.L., et al.: J. Dermatol. Sci., 67, 140 (2012); Chem. and Eng. News page 6 Nov. 10 (2018)<br></p>

<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>

<p>Applications (1R)-(+)-α-Pinene is used in hydroboration reactions and the reduction of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, H. et al.: J. Org. Chem., 50, 1384 (1985);<br></p>

<p>Applications Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).<br>References Baker, W. &amp; White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)<br></p>

<p>Stability Air Sensitive<br>Applications Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, T.R. et al.: Bull. Kor. Chem. Soc., 3, 162 (1982); Badr, M.Z.A. et al.: Bull. Chem. Soc. Jap., 56, 326 (1983); Langler, R.F. et al.: Can. J. Chem., 57, 3193 (1979);<br></p>

<p>Applications 1,5-Diazabicyclo[4.3.0]non-5-ene is used as a nucleophilic catalyst for the Freidel-Crafts C-acylation of pyrroles and indoles. 1,5-Diazabicyclo[4.3.0]non-5-ene is also an inhibitor of indoleamine-N-methyltransferase (II) of rabbit lung in vitro.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandel, L.: Biochem. Pharmacol., 25, 2251 (1976); Taylor, J., et al.: Org. Lett., 12, 5740 (2010)<br></p>

<p>Applications Hydrogen Tetrafluoroborate(1-) is a useful building block for organic synthesis.<br>References Ohkuma, T., et al.: Journal of the American Chemical Society., 218, 8724 (2006)<br></p>

<p>Applications Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.<br>References Liagre B. et al.: Int. J. Mol. Med., 20, 451 (2007);<br></p>

<p>Applications Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.<br>References Geraud, G., et al.: Clin. Ther., 26, 1305 (2004), Bolay, H., et al.: Nat. Med., 8, 136 (2002), Scher, A., et al.: Pain, 106, 81 (2003), Richter, F., et al.: J. Cereb. Blood Flow Metab., 25, 1225 (2005),<br></p>

<p>Applications Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.<br>References Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013);<br></p>

<p>Applications Icilin is a potent agonist of the TRPM8 and ENaCδ ion channels.<br>References Noncovich, A., et al.: Bioorganic Med. Chem. Lett., 27, 3931-38 (2017);<br></p>

<p>Applications PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001), Pop, C., et al.: Biochemistry, 42, 12311 (2003), Li, L., et al.: Science, 305, 1471 (2004), Green, D., et al.: J. Clin. Invest., 115, 2610 (2005), Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009),<br></p>

<p>Applications 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. A potential candidate in the treatment of patients with renal parenchymal hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ohya, Y. et al.: Int. J. Clin. Pharmacol. Therap., 38, 304 (2000); Huh, W. S. et al.: Curr. Therap. Res., 61, 395 (2000); Katoh, M. et al.: Eur. J. Clin. Pharmacol., 55, 843 (2000);<br></p>

<p>Stability Light Sensitive<br>Applications Stereomeric with Cinchonidine (C441925). Antimalarial.<br>References Litchfield, J., et al.: J. Pharm. Exp. Ther., 96, 99 (1949), Trager, W., et al.: Science, 193, 673 (1976), Panisko, D., et al.: Drugs, 39, 160 (1990), Karle, J., et al.: Antimicrob. Agents Chemother., 36, 1538 (1992),<br></p>

<p>Applications Sodium Cyanate is used in biological study as tumor cell proliferation and metabolism inhibition.<br>References Hu, J. J., et al.: Cancer Chemoth. Pharm., 26, 269 (1990);<br></p>

<p>Applications Aliquat 336 is a reagent in the synthesis of Iso Promethazine (I822500, HCl); an impurity of Promethazine (P757000, HCl) which is an antihistaminic, antiemetic, and CNS depressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gasco, M.R., et al.: J. Pharma. Sci., 68, 612 (1979); Edge, W., et al.: J. Pharm. Pharmacol., 5, 279 (1953); Huang, et al.: J. Pharm. Sci., 59, 772 (1970); Shearer, C.M., et al.: Anal. Profiles Drug Subs., 5, 429 (1976)<br></p>

<p>Applications TRIPHENYLBISMUTH (cas# 603-33-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications WAY 100635 exhibits high affinity and efficacy at the dopamine D4 receptor (1,2,3). WAY 100635 is a potent 5-HT1A antagonist.<br>References (1) Tenbrink, R., et al.: J. Med. Chem., 39, 2435 (1996) (2) Khawaja, X., et al.: J. Neurochem., 98, 134 (2006)(3) Martel, J., et al.: Eur. J. Pharmacol., 574, 15 (2007)<br></p>

<p>Applications Udenafil is an oral phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction.<br>References Kim, T. et al.: Br. J. Clin. Pharmacol., 68, 43 (2009); Lee, C. et al.: J. Sex Med., 7, 2564 (2010); Bae, S.K. et al.: Biomed. Chrom., 22, 939 (2008);<br></p>

<p>Applications Potassium Ferrocyanide Trihydrate functions in the DNA-binding, cytotoxicity, cellular uptake, apoptosis and photocleavage studies of ruthenium(II) complexes.<br>References Deepika, N., et al.: J. Photochem. Photobiol., B: Biol., 160, 142 (2016)<br></p>

<p>Applications Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans.<br>References Pertovaara A., CNS Drug Reviews 11 (3), 273 (2005);<br></p>

<p>Stability Light Sensitive<br>Applications Farnesone is s useful building block for organic synthesis<br></p>

<p>Applications Ivacaftor is used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tetrakis(triphenylphosphine)palladium(0) is widely used as a catalyst for palladium-catalyzed coupling reactions.<br>References Malatesta. L., et al.: J. Chem. Soc., 1186 (1957);<br></p>

<p>Applications A silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products. Approximate M.W. 2000.<br>References Disapio, A. et al.: Int. J. Cosmet. Sci. 10, 75(1988)<br></p>

<p>Applications Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).<br>References Greve, J., et al.: Int. J. Dermatol., 50, 1294 (2011); Cole, S.W., et al.: Ann. Pharmacother., 47, 49 (2013)<br></p>

<p>Stability Moisture Sensitive<br>Applications n-Undecanoyl Chloride is an analog of Heptanoyl Chloride (H281235), which is used in the synthesis of novel class of 2-Aminopyrimidines as CDK1 and CDK2 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Samanta, R., et al.: Org. Lett., 14, 5518 (2012); Sabbah, M., et al.: Bioorg. Med. Chem., 20, 4727 (2012)<br></p>

<p>Applications 4-Pyridylthioacetic Acid (cas# 10351-19-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Sodium selenite is used in reducing carcinogenesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Phosphoric Acid Monosodium Salt Dihydrate, is a reagent widely used in the preparation of biological buffers. It is highly hygroscopic and can be used in many applications including in gel electrophoresis.<br>References Salaun, F.: "Influence of mineral environment on the buffering capacity of casein micelles", "Milchwissenschaft", 62(1):3<br></p>