Ácidos y reactivos sintéticos

<p>Stability Moisture Sensitive<br>Applications 4-Morpholinylsulfur Trifluoride is a chemical reagent used in the preparation of proline analogs. Also used in the preparation of difluoropiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mykhailiuk, P. et al.: Tetrahedron 67, 3091 (2011); Surmont, R. et al.: Synlett., 12, 1933 (2009);<br></p>

<p>Applications Calcium Hypochlorite is a general chemical reagent used in the preparation of deicing salt. As well used as a disinfecting agent for pools as well as a disinfecting additive for dental stone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Farnam, Y. et al.: Cement Conc. Comp., 64, 1 (2015); Twomey, J. et al.: J. Prosthet. Dent., 90, 282 (2003);<br></p>

<p>Applications Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid tumors, such as metastatic breast cancer.<br>References Duska, L. et al.: Gynecol. Oncol., 135, 44 (2014); Deeken, J. et al.: Cancer Chemother. Pharmacol., 73, 1071 (2014);<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Indium(III) trifluoromethanesulfonate is a catalyst that is used for hetero Diels-Alder reactions including intermolecular Diels-Alder reactions. It is also a catalyst for efficient acylation of alcohols, phenols and amines.<br>References Kamlesh, K.C., et al.: Synlett, 1999, 1743 (1999), Ali, T., et al.: Tetrahedron Lett., 40, 5621 (1999)<br></p>

<p>Applications Synthetic pentasaccharide corresponding to the anti-thrombin binding site of heparin. Anti-thrombotic.<br>References Herbert, J.M., et al.: Cardiovasc. Drug Rev., 15, 1 (1997), Turpie, A.G.G., et al.: Expert Opin. Drug Saf., 4, 707 (2005),<br></p>

<p>Applications Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.<br>References Rosen, L., et al.: J. Clin. Oncol., 25, 2369 (2007), Sherman, S., et al.: New Engl. J. Med., 359, 31 (2008),<br></p>

<p>Applications Batyl Alcohol is used to synthesize amphiphilic alkylglycerolipids with antitumor activities. It is also used in cosmetic compounds for prevention or treatment of erythema or dermatitis or promotion of wound healing.<br>References Ukawa, K., et al.: Chem. Pharma. Bull., 37, 3277 (1989); Schoenrock, U., et al.: Ger. (1995), DE 4420625 C1 19951102.<br></p>

<p>Stability Hygroscopic<br>Applications A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.<br>References Lau, O.D. et al.: Mol. Cell, 5, 589 (2000);<br></p>

<p>Applications The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3ß inhibitor (IC50=23nM).<br>References Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999), Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001), Bain, J., et al.: Biochem. J., in press.<br></p>

<p>Applications 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid (cas# 60875-16-3) is a useful research chemical.<br></p>

<p>Stability Very Hygroscopic<br>Applications Gadolinium Trichloride is a calcium-sensing receptor agonist and is known to work by inducing NLRP3 inflammasome activation in bone marrow-derived macrophages.<br>References Toyoda, Y., et al.: Toxicol. Sci., 126, 16 (2012); Ciceri, P., et al.: Biochem. Biophy. Res. Comm., 418, 770 (2012); Dangi.A., et al.: J. Immunol., 188, 3667 (2012);<br></p>

<p>Applications 4-(t-Boc-amino)-1-butyl Bromide (cas# 164365-88-2) is a compound useful in organic synthesis.<br>References Bendale, P., et al.: J. Med. Chem., 50, 4585 (2007), Lansdell, M., et al.: Bioorg. Med. Chem. Lett., 18, 4944 (2008), Imaeda, Y., et al.: Bioorg. Med. Chem., 16, 2243 (2008),<br></p>

<p>Stability Light Sensitive<br>Applications Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.<br>References Andrade, R.J., et al.: Hepatol., 44, 1581 (2006); Wajima, T., et al.: J. Pharma. Sci., 92, 2427 (2003); Sentellas, S.. et al.: J. Chroma., 976, 221 (2002);<br></p>

<p>Applications Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 &gt;100nM).<br>References Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)<br></p>

<p>Applications Methyl 8-Chloro-8-oxooctanoate is used as a reagent in the synthesis of β-cyclodextrin-6-deoxy-6-NHC(O)(CH2)6C(O)NHOH which is a β-cyclodextrin-capped histone deacetylase inhibitor that may have potential for use in treatment of cancers and inflammatory diseases. It is also used in one synthetic route for tubacin which is a known anticancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amin, J., et al.: Bioorg. Med. Chem. Lett., 23, 3346 (2013); Hong, J., et al.: Lett. Org. Chem., 7, 50 (2010);<br></p>

<p>Applications 5-Hydroxymatrineis an alkaloid isolated from Chines Sophorae radix and Sophora tomentosa L..<br>References Ota, N., et al.: Shoyakugaku Zasshi, 33, 140 (1979); Komatsu, M., et al.: Cem. Pharm. Bull., 26, 3863 (1978)<br></p>

<p>Applications K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.<br>References Sanvitale, C.E., et al.: PLoS One, 8, e62721 (2013)<br></p>

<p>Applications Dihydrokainic acid is an EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake.<br>References Grunewald, M., et al.: J. Biol. Chem., 275, 9684 (2000); Shimamoto, K., et al.: Mol. Pharmacol., 53, 195 (1998);<br></p>

<p>Applications Bevirimat is a HIV-1 maturation inhibitor, targetting the Gag CA-SP1 cleavage site. HIV Inhibitor.<br>References Coric, P. et al.: Eur. J. Med. Chem., 62, 453 (2013); Waki, K. et al.: PLoS Path., 8, e1002997 (2012);<br></p>

<p>Applications (R)-3-(Boc-amino)piperidine is Boc protected (R)-3-Aminopiperidine (A627920, Dihydrochloride salt) which has been used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin.<br>References Xie, Hui., et. al.: Eur. J. Med. Chem., 68, 312 (2013)<br></p>

<p>Applications 5-(Trifluoromethyl)picolinic Acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.<br>References Tresadern, G., et al.: Bioorg. Med. Chem. Lett., 21, 7255 (2011); Watanabe, T., et al.: Bioorg. Med. Chem., 20, 5839 (2010);<br></p>

<p>Applications 4-(2,3-Dimethoxyphenyl)butanoic acid is a butyrate analogue with effects on apoptosis, proliferation and histone deacetylase (HDAC) activity in HT-29 colorectal cancer cells.<br>References Scheppach, W., et al.: Eur. J. Cancer, 31A, 1077 (1995), Wu, J., et al.: J. Lipid Res., 46, 1944 (2005), Kiefer, J., et al.: Br. J. Nutr., 96, 803 (2006),<br></p>

<p>Applications Trimethylphenylammonium tribromide is a brominating agent, and is also used as an oxidizing agent in the preparation of disulfides and sulfoxides from thiols and sulfides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ghorbani-Choghamarani, A., et al.: Phosphorus Sulfur, 186, 1665 (2011); Gonzalez, A., et al.: Phytochemistry, 12, 1113 (1973)<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications 3-Hydroxyquinoline is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetragedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002);<br></p>

<p>Applications Methyl 2,​5-​Dihydroxybenzoate is a general reagent used in the synthesis of angiogenesis inhibitors that display anti-tumor activity.<br>References Marin-Ramos, N. et al.: J. Med. Chem, 58, 3757 (2015);<br></p>

<p>Applications 18α-Glycyrrhetinic Acid rapidly and reversibly blocks gap junction intercellular communication (GJIC).<br>References Guo, Y., et. al.: Am. J. Phys.: 276, L1018 (1999)<br></p>

<p>Applications Precursor to Kifunensine.<br>References Kayakiri, H., et al.: Chem. Pharm. Bull., 39, 1378 (1991),<br></p>

<p>Applications DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br>Chemical Name: DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br></p>

<p>Applications AMG 337 is a potent and selective inhibitor of mesencymal epethelial transition factor (MET factor) which has been implicated in several cancers.<br>References Boezio, A. et al.: J. Med. Chem., 59, 2326 (2016);<br></p>

<p>Applications Lithium Chloride is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br>References Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications A metabolite of Cilostazol (C441500), used as internal standard.<br>References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),<br></p>

<p>Applications Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.<br>References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>

<p>Applications Lithium hydroxide is a reagent that is used in the synthesis of O-Desmethyl Mebeverine Acid O-β-D-Glucuronide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disea<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Applications rac 2-Lauroyl-3-chloropropanediol-d5 (cas# 1330055-73-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Diphenyl Phosphite is a reactant used in the synthesis of α-hydroxyphosphonates and α-hydroxyphosphinates for their antioxidant and antimicrobial activity.<br>References Sampath, C. et al.: Phosphor. Sulfur Silicon. Rel. Elem., 191, 95 (2016);<br></p>

<p>Applications TETRAMETHYLAMMONIUM BOROHYDRIDE (cas# 16883-45-7) is a useful research chemical.<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications 5-Methylsalicylamide (cas# 39506-61-1) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Indium(III) chloride tetrahydrate (cas# 22519-64-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its analogues.<br>References Neyyarapally, A.T. et al.: Ind. J. Chem., 11, 325 (1973); Jones, C.D. et al.: J. Med. Chem., 27, 1057 (1984); Nakata, K. et al.: Molecules, 15, 6773 (2010);<br></p>

<p>Applications A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Misumi, Y., et al.: J. Biol. Chem., 261 (1986), Mordente, J.A., et al.: J. Urol., 159, 275 (1998), Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1999), Nojiri, H., et al.: FEBS Letters, 453, 140 (1999),<br></p>

<p>Applications N-Boc-hydroxylamine is the protected form of Hydroxylamine (HCl: H943705). Hydroxylamine is used as an inhibitor between Z and P680 in photosystem II within plant chloroplasts. Hydroxylamine is also known to induce chromosomal damage in mammalian cells, inducing mutagenesis.<br>References Ghanotakis, D. &amp; Babcock, G.: FEBS Lett., 153, 231 (1983); Somers, C. &amp; Hsu, T.: P. Natl. Acad. Sci. USA, 48, 937 (1962)<br></p>

<p>Applications 2-(2-Aminophenyl)-1H-benzimidazole is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins. Also used in the synthesis of pharmaceutical agents targeting leishmania related parasites.<br>References Keurulainen, L. et al.: Bioorg. Med. Chem. Lett., 25, 1933 (2015); He, Y. et al.: Bioorg. Med. Chem., 23, 2798 (2015);<br></p>

<p>Applications 12-CROWN-4 (cas# 294-93-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Dimethylaminobenzylamine is used in the preparation of N-benzyl and N-aryl furylpurines as inhibitors of mycobacteria for potential use as antituberculosis agents.<br>References Bakkestuen, A., et al.: Bioorg. Med. Chem. Lett., 10, 1207 (2000), Gundersen, L., et al.: Med. Chem., 45, 1383 (2002),<br></p>

<p>Applications 6-Bromo-2H-1,4-benzoxazin-3(4H)-one is used in the synthesis of substituted benzoxazinones; selective 5-HT6 antagonists used for treating central nervous system diseases and gastrointestinal tract disorders.<br></p>

<p>Applications Fmoc-beta-alaninol<br></p>

<p>Applications 4-Bromostyrene<br></p>

<p>Stability Moisture Sensitive<br>Applications Bromotripyrrolidinophosphonium Hexafluorophosphate is a peptide coupling reagent that has been used in the synthesis of rostate tumor specific peptide-peptoid hybrid prodrugs.<br>References Li, S., et. al.: Chem. Commun., 47, 12840 (2011); Lee, J., et. al.: Bioorg. Med. Chem. Lett., 25, 2849 (2015)<br></p>

<p>Applications 4-Formyl-2-nitrophenol is an Intermediate used in synthesis of novel amodiaquine analogs as potential antimalarial and antifilarial compounds.<br>References Jiang, D.X., et al.: Int. J. Environ. Res., 5, 923 (2011); Al-Zereini, W., et al.: J. Antibiotic., 63, 297 (2010);<br></p>

<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>

<p>Applications 4-Fluoro-3-nitrobenzenesulfonyl chloride is a used in the preparation of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.<br>References Zhou, Haibin., et al.: J. Med. Chem., 55, 6149 (2012);<br></p>

<p>Applications 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cui, H., et al.: J. Med. Chem., 55, 10948 (2012); Kim, H., et al.: Bull. Kor. Chem. Soc., 34, 2311 (2013)<br></p>

<p>Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.<br>References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)<br></p>

<p>Applications Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.<br>References Kuntzman, R., et al.: Clin. Pharmacol. Ther., 11, 829 (1970), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Carter, J.E., et al.: Anal. Profiles Drug Subs., 9, 71 (1980),<br></p>

<p>Applications (S)-4-(prop-1-En-2-yl)cyclohex-1-enecarbaldehyde (cas# 18031-40-8) is a useful research chemical. A possible biomarker of Parkinson’s disease.<br>References Drupad, K. T., et al.: ACS Central Science, (2019)<br></p>

<p>Stability Air Sensitive (Oxidize)<br>Applications 3,3-Dimethylbutyraldehyde is an intermediate used to prepare spiro-oxindoles as potent, specific small-molecule Inhibitors of the MDM2-p53 Interaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ding, K., et al.: J. Med. Chem., 49, 3432 (2006); Yu, S., et al.: J. Med. Chem., 52, 7970 (2009)<br></p>

<p>Applications A useful wittig reagent.<br></p>

<p>Applications Disodium Tetrachloropalladate is an inorganic compound used in organometallic chemistry for the preparation of phosphine complexes of palladium.<br>References Ramirez-Rave, S., et al.: J. Orgometallic. Chem., 749, 287 (2014);<br></p>