Ácidos y reactivos sintéticos

<p>Applications Osmium Tetroxide (4% in H2O) is a reagent that is used in the dihydroxylation process in the synthesis of 3-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]-1,2-propanediol (D436535). 3-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]-1,2-propanediol is involved in biological studies as microsomal cytochrome P 450 isoenzymes from Penicillium italicum interaction with sterol demethylation inhibitor fungicides.<br>References Guan, J., et al.: Pest. Biochem. Physiol., 42, 24 (1992);<br></p>

<p>Applications Isobutyl Acetoacetate is a building block that has been used as a reactant in the preparation of b-annulated 1,4-dihydropyridine derivatives as TGFβ signaling inhibitors.<br>References Schade, D., et. al.: J. Med. Chem., 55, 9946 (2012)<br></p>

<p>Applications [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II), is a palladium catalyst used in chemical synthesis of various compounds.<br></p>

<p>Applications Vanadium(IV) Oxide Acetylacetonate is used as a catalyst in organic chemistry and is also an intermediate in synthetic reactions, such as the synthesis of novel oxovanadium complexes that display antitumor activity.<br>References Rui, W. et al.: Polyhedron, 117, 803 (2016); Tahmasebi, V. et al.: J. Mol. Struct., 1123, 367 (2016);<br></p>

<p>Applications (R)-5-Oxotetrahydrofuran-2-carboxylic Acid is an intermediate used to synthesize 2',3'-dideoxy-4'-selenonucleosides as potential antiviral agents.<br>References Jeong, L., et al.: Bioorg. Med. Chem., 16, 9891 (2008)<br></p>

<p>Applications Zinc Bromide is used as a catalyst in the synthesis of tetrazoles which exhibit antibacterial activity in vitro. Zinc Bromide is also a zinc salt that is added as a nutritional or functional ingredient in food and oral care products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cui, J., et al.: Xiandai Shengwuyixue Jinzhan, 12, 3478 (2012); Keast, R.S.J.: J. Food Sci., 68, 1871 (2003)<br></p>

<p>Applications Copper(I) Chloride, has many applications. The main use of copper(I) Chloride is as a precursor to the fungicide copper oxychloride. In organic synthesis, CuCl is used as an initiator of radical reactions such as the hydrostannation of α,β-unsaturated ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wade, L. G., et al.: Org. Chem., 5th Ed., 871 (2003); Ooi, T., et al.: Tetrahedron Lett., 40, 2133 (1999);<br></p>

<p>Applications [1,2-Bis(diphenylphosphino)ethane]dichloropalladium(II) is a precatalyst used in the production of acrylic acid sodium salt via coupling of CO2 with ethene.<br>References Vavasori, A.; et al.: Pure Appl. Chem., 90, 315 (2018).<br></p>

<p>Applications Tetrakis(acetonitrile)palladium Bis(tetrafluoroborate) is used to prepare an α-Diimine-transition metal complex, which is used as a catalyst for polymerization of olefins. It is also a catalyst used in cross coupling reaction for C-C, C-O, and C-N bond formation.<br>References Feldman, J., et al.: Organometallics, 16, 1514 (1997); Johnson, L., et al.: PCT Int. Appl., WO 9623010 A2 19960801 (1996); Poppenbery, J., et al.: Surface Sci., 2011; Pijnenburg, N., et al.: Dalton Transactions, 40, 8896 (2011); Kilpin, K., et al.: Inorg. Chem., 50, 6334 (2011)<br></p>

<p>Applications (S)-Benzyl 2-(5-Bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate is an intermediate in the synthesis of ent-Eletriptan (E505005), an enantiomeric impurity of the serotonin 5-HTIB/ID receptor agonist Eletriptan (E505000).<br>References Orita, A., et al.: Green Chem., 3, 13 (2001);<br></p>

<p>Applications Diisopropyl Azodicarboxylate is an azodicarboxylic acid derivative used as a reagent in the production of many organic compounds. Diisopropyl Azodicarboxylate is commonly used as an oxidizer in Mitsunobu reactions and can also serve as a selective deprotectant of N-benzyl groups in the presence of other protecting groups.<br>References Pichika, R. et al.: Nuc. Med. Biol., 38, 1183 (2011); Kroutil, J. et al.: Synthesis, 3, 446 (2004); Hughes, D.L. et al.: Org. React., 42, 335 (1992);<br></p>

<p>Applications Dilithium Tetrachlorocuprate is an intermediate used in the synthesis of 10-Methylundecanol (M338110), an intermediate in the synthesis of Sulfobacin A;Also, it is derived from Lithium Chloride (L469105), which is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamiyama, T., et al.: J. Antibiot., 48, 924 (1995), Gupta, P., et al.: Tetrahedron Lett., 45, 9641 (2004); Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications CataCXium A is a catalyst. CataCXium A is an electron-rich phosphine ligand used for palladium catalyzed cross-coupling reactions like Heck and Suzuki coupling reactions.<br>References Martek, B. A., et al.: Org. Lett., PagesAhead of Print (2020); Geng, H., et al.: Org. Lett., 22, 1160 (2020); Carny, T., et al.: J. Org. Chem., 84, 12499 (2019); Martin, S. C., et al.: ACS Med. Chem., 10, 1380 (2019); Takale, B. S., et al.: Chem. Sci., 10, 8825 (2019)<br></p>

<p>Applications Methyl α-bromophenylacetate is used in synthetic chemistry as an initiator for polymerization reactions (such as the polymerization of methyl methacrylate). Methyl α-bromophenylacetate is also used as a reagent to synthesize compounds that act as selective Serotonin (HCl: S274980) reuptake inhibitors (SSRI). SSRIs are used to modulate symptoms in autistic patients.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fors, B. &amp; Hawker, C.: Angew. Chem. Int. Edit., 51, 8850 (2012); Ghoneim, O., et al.: Bioorgan. Med. Chem. Lett., 21, 6714 (2011); O’Reilly, R., et al.: Macromolecules, 40, 7441 (2007)<br></p>

<p>Applications Ruthenium(IV) Oxide Hydrate is a coalescence inhibitor of hydrous RuO2 crystallites for capacitor electrodes preparation in hydrothermal process.<br>References Chang, K., et al.: Appl. Phys. Lett., 88, 193102 (2006)<br></p>

<p>Applications Tris(acetonitrile)cyclopentadienylruthenium(II) Hexafluorophosphate is a catalyst, and catalyzes the reaction of diynes with aldehydes and N,N-dimethylformamide and also catalyzes other organic reactions.<br>References Yamamoto, Y., et al.: J. Org. Chem., 82, 7964 (2017); Weber, S. M., org. lett., 19, 564 (2017); Wilkinson, L. A., et al.: Organometallics, 36, 4376 (2017)<br></p>

<p>Applications AMMONIUM IODIDE (cas# 12027-06-4) is a useful research chemical.<br></p>

<p>Applications Copper (II) Bromide is used as a catalyst in chemical reactions. Used in the coupling of o-Iodophenols and aryl acetylenes avoiding the use of palladium. Copper (II) Bromide is also used in the preparation of NK1/NK2 receptor antagonists used in the regulation of tachykinin.<br>References Bates, C. et al.: Org. Lett., 4, 4727 (2002); Albert, J. et al.: 45, 4972 (2002);<br></p>

<p>Applications Benzyltributylammonium Bromide (cas# 25316-59-0) is a useful research chemical.<br></p>

<p>Applications 5,6,7,8-Tetrahydro-1-naphthylamine is used as a reagent in the synthesis of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. 5,6,7,8-Tetrahydro-1-naphthylamine is also used as a reagent in the synthesis of benzopyrans and related compounds as inhibitors of the hypoxia inducible factor pathway.<br>References Roy, S., et al.: Eur. J. Med. Chem., 75, 426 (2014); Mooring, S.R., et al.: J. Med. Chem., 54, 8471 (2011)<br></p>

<p>Applications 2-Nitropropane is an oxidative stress-inducing agent and also a carcinogen. It is used in the induction of DNA polymerase β-dependent base excision repair in response to oxidative stress in the liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cabelof, D.C., et al.: Carcinogenesis,23, 1419 (2002); Kreis, P., et al.: Carcinogenesis, 21, 295 (2000)<br></p>

<p>Applications DI-TERT-BUTYLSILANE (cas# 30736-07-3) is a useful research chemical.<br></p>

<p>Applications Copper(I) cyanide is useful as a catalyst and as a reagent in the preparation of nitriles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dieter, R.K., et al.: J. Org. Chem., 79, 1125 (2014);<br></p>

<p>Applications (S)-(-)-Glycidol is a cyclic AB 2-type monomer that can be polymerized in a ring-opening multibranching polymerization. S)-(-)-Glycidol is also used as a starting reagent to synthesize non-peptidic HIV protease inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chiummiento, L., et al.: Tetrahedron, 65, 5984 (2009); Tokar, R., et al.: Macromolecules, 27, 320 (1994)<br></p>

<p>Stability Light Sensitive<br>Applications Butyl Nitrite is reagent used in the preparation of p-hydroxyphenylpyruvate dioxygenase inhibitors which has herbicidal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Witschel, M., Bioorg. Med. Chem., 17, 4221 (2009)<br></p>

<p>Applications Mesitylcopper is an organometal used to synthesize compounds such as copper diketonate complexes.<br>References Larson, Alec. et al., Inorg. Chem. 59, 423-432(2020);<br></p>

<p>Applications Tetraethylammonium P-Toluenesulfonate (cas# 733-44-8) is a useful research chemical.<br></p>

<p>Applications Acetylenedicarboxylic Acid is used as an electrolyte in the fabrication of anodic nanoporous alumina. It is also used as a reagent in the synthesis of several organic compounds including that of derivatives of metronodazole (antibiotic and antiprotozoal medication) which display increased antimicrobial and antiparasitic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kikuchi, T., et al.: Electrochem. Lett., 3, C25 (2014); Al-Masoudi, N., et al.: Monatsh. Chem., 147, 383 (2016);<br></p>

<p>Applications Sodium sulphate decahydrate (CAS# 7727-73-3) is a useful research chemical compound.<br></p>

<p>Applications Synthetic intermediate. Can be used in the synthesis of dialkylphenanthrenylamines.<br></p>

<p>Applications 2,4-Dichlorobenzoyl Chloride is a reactant used in the synthesis of aroyl(sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mahdavi, M., et. al.: Eur. J. Med. Chem., 82, 308 (2014)<br></p>

<p>Applications 3-Bromo-2-methylbenzoic Acid is a disubstituted benzoic acid used in the preparation of various biologically active compounds such as α-2 adrenoceptor agonists, Smootherned receptor anatogonists and HIV-1 entry inhibitors.<br>References Stoilov, I. et al.: J. Hetercyc. Chem., 30, 1645 (1993); Katritzky, A. et al.: J. Med. Chem., 52, 7631 (2009); Pan, S. et al.: ACS Med. Chem. Lett., 1, 130 (2010);<br></p>

<p>Applications Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents.<br>References Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986), Miller, K.D., et al.: Invest. New Drugs, 22, 69 (2004), Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (2004), Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005)<br></p>

<p>Applications 1,5-Cyclooctadiene(pyridine)(tricyclohexylphosphine)iridium(I) Hexafluorophosphate is a catalyst that is used in the synthesis of 4α,5-Dihydro Simvastatin (D450010). 4α,5-Dihydro Simvastatin is an impurity in the synthesis of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>

<p>Applications 4-Amino-1-(diethylamino)pentane was used as a reagent in the synthesis of chromone-2-carboxamide derivatives which displayed cytotoxic activity against specific cancer cell lines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bousejra-ElGarah, F., et al.: Med. Chem. Res., 1054, pages ahead of print (2016);<br></p>

<p>Applications 3-Morpholinopropylamine is a reactant used in the preparation of pyridinyl-quinazolinone derivatives as potential anti-influenza A virus compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, S., et. al.: Chem. Biol. Drug Design., (Ahead of Print) (2015)<br></p>

<p>Applications Diisopropyl Malonate is a disinfection byproduct of Isoprothiolane (I874300); a dithiolane pesticide commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.<br>References Chin, K.M.: Malay. Agric. J., 50, 221 (1975); Ikeda, Y. et al.: Biosci. Biotech. Biochem., 57, 288 (1993); Nakamura, H.: Rev. Plant Prot. Res., 10, 1 (1977); Reddy, A.P.K. et al.: Pesticide, 22, 21 (1988); Jinno, H., et al.: Arch. Toxicol., 71, 550 (1997)<br></p>

<p>Stability Hygroscopic<br>Applications 3-Phenylpropylamine is an compound used for the synthesis of various pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamochi, Y., et al.: Tetrahedron. Lett., 32, 3511 (1991);<br></p>

<p>Applications Trichloroacetic Anhydride is used in organometallic reactions as well as oxadiazole containing 5-lipoxygenase activating protein inhibitors.<br>References Takahashi, H. et al.: J. Med. Chem., 58, 1669 (2015);<br></p>

<p>Applications LITHIUM FLUORIDE (cas# 7789-24-4) is a useful research chemical.<br></p>

<p>Applications 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is an heterocyclic building block used in the synthesis of various chemical compounds.<br></p>

<p>Applications Chloro(triethylphosphine)gold is an analogue of auranofin. Auranofin and its analogs show antimicrobial activity against multidrug-resistant pathogens<br>References Tizian M. et al.: Chem. Med. Chem. 13(22), 2448-2454 (2018)<br></p>

<p>Applications Bariumhydroxidemonohydrate (cas# 22326-55-2) is a useful research chemical.<br></p>