Compuestos halogenados

Applications 2,4'-Dibromobenzophenone (CAS# 78281-59-1) is a useful research chemical compound.

Applications 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)

Applications 4,5-Dibromo-2-benzoylpyrrole is used in preparation of 2,3-Dibromo-5-benzoyl Pyrrole via amidation of morpholine with Benzoyl Chloride, followed by Friedel-Crafts reaction with pyrrole and substitution with Br2.
References Yang, Q., et al.: Faming Zhuanli Shenqing, (2012);

Applications 1-CHLOROHEXANE (cas# 544-10-5) is a useful research chemical.

Applications 6-Fluoro-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a useful research chemical.

Applications 4-((4-Chlorophenyl)(phenyl)methyl)-1,1-Bis(2-(2-hydroxyethoxy)ethyl)piperazin-1-ium Bromide is a useful research compound.

Applications N-(2,4-Dichloro-5-methoxyphenyl)acetamide is a reactant used in the chlorination of acetanilides with benzyltrimethylammonium tetrachloroiodate(B316185).
References Kajigaeshi, S., et al.: Bull. Chem. Soc. Jpn., 63, 941 (1990)

Applications 5-FLUORO-2,3-DIHYDROBENZOFURAN (cas# 245762-35-0) is a useful research chemical.

Applications 2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin is an intermediate in the synthesis of N-Dides(2-chloroethyl) N-(2-Hydroxyethyl),N-(2-ethoxyethyl) Cyclophosphamide (C984610) which is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.
References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)

Applications N-(2-Bromo-5-fluorophenyl)acetamide is a reagent in the preparation of fluorinated rhodacyanine analogues with antileishmanial properties.
References Lasing, T., et al.: Bioorg. Med. Chem., 28, 115187 (2020)

Applications p-Chlorobenzoyl anisole is a reagent used in the synthesis of styrenyl ethers via Bamford-Stevens reaction of aryloxy/alkoxy acetophenones.
References Mete, T. B. et al.: Chem. Selec. 3(26), 7656-7659. (2018)