Anillos de 6 miembros

Applications Methyl 3-(Hydroxymethyl)benzoate is used in the synthetic preparation of N-acylhydrazone derivatives as lactate dehydrogenase A inhibitors.
References Rupiani, S., et al.: J. Med. Chem., 101, 70 (2015)

Applications 4-phenyl-2,3-dihydroquinazolin-2-one (cas# 23441-75-0) is a useful research chemical.

Applications 5-(Benzyloxy)-2-((benzyloxy)carbonyl)-3-hydroxy-5-oxopentanoic Acid is an intermediate used in the synthesis of 2-[2-[(5-carboxypentyl)amino]-2-oxoethyl]-2-hydroxybutanedioic Acid (C181175), which is derived from Methyl 6-Aminohexanoate Hydrochloride (M287100), which is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.
References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)

Applications Perphenylcyclopentasilane is an intermediate in the synthesis of Cyclopentasilane (C988380), a reagent used for depositing silicon on surfaces for electronics applications.
References Morisaki, Y., et al.: Chem. Lett., 38, 498 (2009);

Applications 3-Nitrobenzoylacetonitrile (cas# 21667-64-1) is a useful research chemical.

Applications 5-Benzyl Hydantoin (cas# 3530-82-3) is a compound useful in organic synthesis.
References Suzuki, S., et al.: J. Bacteriol., 188, 3329 (2006), Jiang, M., et al.: Enz. Microb. Technol., 41, 407 (2007),

Applications Methyl 4-Chlorobenzoate is a reactant used in the synthesis of ataxia-telangiectasia mutated (ATM) kinase, a target for novel radiosensitizing agents. As well, used as a reactant in the synthesis of aminopyridine functionalized polyacrylonitrile fibers.
References Min, J. et al.: J. Med. Chem., 59, 559 (2016);

Applications 3-(4-Biphenyl)propionic Acid is a reactant in the preparation of 1,3,4-oxadiazole containing histone deacetylase inhibitors with anticancer activity.
References Valente, S., et. al.: J. Med. Chem., 57, 6259 (2014)

Applications Benzo[a]pyrene-3,6-quinone is a metabolite of Benzopyrene (B205800) and is able to induce epidermal growth factor receptor (EGFR) cell signaling in human mammary epithelial cells. Also highly mutagenic and carcinogenic.
References Rodriguez-Fragoso, L., et al.: Toxicol. Appl. Pharm., 235, 321 (2009); Sen, S., et al.: Chem. Res. Toxicol., 25, 2117 (2012)

Applications [4-(Cyclopropylmethyl)phenyl]methanamine Hydrochloride is a useful research chemical for organic synthesis.

Applications Reagent used in the preparation of pharmaceutically active Dibenzocyclohenptenes.

Applications 4-(Morpholin-4-yl)cyclohexanone is a useful synthetic intermediate. It was used to synthesize diastereomeric 3,6-diaminobicyclo[3.1.0]hexane derivatives.
References Vilsmaier, E., et al.: Synthesis, 12, 1142 (1991)

Applications β-oxo-Cyclohexanepropanenitrile is used in the preparation of pyrazoloquinazolinone derivatives as PARP-1 inhibitors. In addition, it is used in the preparation of benzoxazoyl amino cyanopyrimidines which act as negative allosteric mGlu5 modulators. Used in anxiety, depression and addiction treatment.
References Orvieto, F. et al.: Bioorg. Med. Chem. Lett., 19, 4196 (2009); Mueller, R. et al.: ChemMedChem., 7, 406 (2012);

Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9