Glycoscience

2-Acetamido-2-deoxy-N-(2-(2-aminoethoxy)ethoxy)acetylaminohexanoyl-b-D-glucopyranosylamine is a modification of oligosaccharide and a carbohydrate. This chemical has been custom synthesized and is available in high purity. It is a complex carbohydrate, which belongs to the group of saccharides. 2-Acetamido-2-deoxy-N-(2-(2-aminoethoxy)ethoxy)acetylaminohexanoyl-b-D-glucopyranosylamine has CAS No. 208668901 and can be found under glycosylation, methylation, and fluorination.

Phenyl a-D-thiogalactopyranoside is a sugar with a galactose and thioglucose residue linked by an alpha-1,6 glycosidic bond. It is obtained from the hydrolysis of starch or starch derivatives such as maltodextrin. This compound can be modified through various reactions, including fluorination, glycosylation, methylation, and modification. Phenyl a-D-thiogalactopyranoside has CAS number 5664-77-5 and molecular weight of 288.24 g/mol.

2,6-Anhydro-3-deoxy-D-lyxo-hept-2-enonimidamide monohydrochloride is a fluorinated sugar that has been custom synthesized to be used as a glycosylation or polysaccharide modification. It has been methylated and click modified to increase its purity. 2,6-Anhydro-3-deoxy-D-lyxo-hept-2-enonimidamide monohydrochloride is also known by the CAS number 180336-29-2.

Cellotetraitol is a carbohydrate that has been isolated from the fungus Penicillium. It is a white crystalline solid that can be synthesized by hydrolyzing cellulose to cellobiose and then heating this sugar with acetic anhydride in the presence of sodium hydroxide. Cellotetraitol has two isomers, one of which is more active than the other. The most active form of cellotetraitol can be obtained as a crystalline solid at room temperature and has an optimal pH of 5. Cellotetraitol can be used for the synthesis of polyacrylamide gels, which are used to separate carbohydrates according to their size and charge.

Lipid X is a monosaccharide precursor of E. coli lipid A. It is an N-acyl-D-glucosamine 1-phosphate where the N-acyl group is (R)-3-hydroxytetradecanoyl and carrying an additional (R)-3-hydroxytetradecanoyl, and it is a component of the cell wall of Gram-negative bacteria. Due to its physiological functions and biological properties, Lipid X can be used to treat infectious diseases, autoimmune diseases, and HIV infection. It has also been shown to inhibit the production of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β). This effect is due to its ability to disrupt hydrogen bonds between lipids in the cell membrane. As a biosynthetic intermediate of Lipid A, it seems to play a role in bacterial virulence and can trigger an immune response in humans, and protect against endotoxins.

Pectin is a highly complex polysaccharide matrix that is found in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms, including potato. A key fragment of this complex is rhamnogalacturonan I, containing a backbone of the repeating disaccharide  [-4)-α-D-GalpA-(1,2)-α-L-Rhap-(1,]. Several applications for RG1 have been described including drug targeting to the colon via the oral administration route for local treatment of e.g. inflammatory bowel disease and colon cancer.  This has several advantages such as needle-free administration and low infection risk. In the gastro-intestinal tract RG-I is only degraded by the action of the colonic microflora. High purity rhamnogalacturonan I is also used in research, biochemical enzyme assays and in vitro diagnostic analysis.

Methimazole is a drug that inhibits the synthesis of thyroid hormones by blocking the action of thyroperoxidase. Methimazole thio-b-D-glucuronide is a non-toxic, water-soluble derivative of methimazole. It is used in the treatment of hyperthyroidism and thyrotoxicosis. This compound can be synthesized from methimazole by click chemistry, fluorination or glycosylation. The product can be custom synthesized with high purity and high carbohydrate content.

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