Glycoscience

1,3-O-Benzylidene-L-erythritol is a potent inhibitor of the intestinal maltase. It has two diastereomers, one of which is more potent than the other. The more potent diastereomer inhibits both the maltase and L-arabinose isomerase enzymes in the intestine. This inhibition prevents digestion of complex carbohydrates such as starch and sucrose into simple sugars that can be absorbed by the body. 1,3-O-Benzylidene-L-erythritol also inhibits salacinol synthase and thiosugar synthetases from bacteria and plants, preventing synthesis of these important compounds.

Phenyl-alpha-D-glucopyranoside is a molecule that is found in the β-cell of the pancreas. It is thought to be involved in the biosynthesis of oligosaccharides and interacts with other molecules to form glycosidic bonds. The interaction between phenyl-alpha-D-glucopyranoside and other molecules has been analysed by gas chromatography, which showed that it was hydrophobic, but also interacted with carbohydrates. Phenyl-alpha-D-glucopyranoside has also been shown to inhibit gram negative bacteria, such as Escherichia coli or Salmonella enterica.

1,5-Dideoxy-1,5-imino-D-xylitol is a synthetic molecule that inhibits the enzyme glycinamide ribonucleotide transformylase (GART) and blocks the synthesis of purines. 1,5-Dideoxy-1,5-imino-D-xylitol has been shown to be potent in inhibiting GART with an IC50 of 0.3 μM. This inhibitory effect was observed in Sprague Dawley rats after oral administration of 1,5-dideoxy-1,5 imino D xylitol at a dose of 10 mg/kg. The inhibition was found to be specific for amination reactions that are catalyzed by GART and not by other enzymes such as glycine amidinotransferase or adenylate kinase. It can be used to study the structure and function of tissue cells.

Diosmetin-d3-3'-O-glucuronide is a synthetic sugar derivative that is used as a building block for the synthesis of oligosaccharides and polysaccharides. Diosmetin-d3-3'-O-glucuronide can be fluorinated and methylated, which makes it useful for click chemistry reactions, because it can be easily modified to create new structures. This product is available in high purity with custom synthesis options.

The Galactomannan from Aspergillus fumigatus consistists of a mannose backbone with galactose side groups, more specifically, a (1-4)-linked b-D-mannopyranose backbone with branchpoints from their 6-positions linked to a-D-galactose, (i.e. 1-6-linked a-D-galactopyranose). This polysaccharide is a component of the cell wall of the mold Aspergillus and is released during growth. Detection of galactomannan in blood is used to diagnose invasive aspergillosis infections in humans. This is performed with monoclonal antibodies in a double-sandwich ELISA; the assay was approved by the FDA in 2003 and is of moderate accuracy.

Phenyl 2,6-di-O-acetyl-3,4-O-isopropylidene-b-D-thiogalactopyranoside is a fluorinated monosaccharide that exhibits high purity and custom synthesis. It is used as a building block for the synthesis of complex carbohydrates. This product is also used for glycosylation, polysaccharide modification, or click modification. Phenyl 2,6-di-O-acetyl-3,4-O-isopropylidene b -D thiogalactopyranoside has CAS number 12447699 and molecular weight of 390.38g/mol.

Methyl 2,4,6-tri-O-acetyl-b-D-glucopyranoside is a modified sugar that is synthesized by a click reaction. This compound has been shown to be an efficient glycosylide donor for the synthesis of complex carbohydrates. Methyl 2,4,6-tri-O-acetyl-b-D-glucopyranoside has been used in the synthesis of oligosaccharides and glycosylated proteins.

Glucosamine is a hexose sugar that is an amino sugar and a precursor in the biosynthesis of glycoproteins. It also acts as an intermediate for the synthesis of other non-carbohydrate natural products. 6-O-Acetyl-2-azido-3,4-di-O-benzyl-2-deoxyglucopyranose is a glucosamine derivative that has been synthesized from trifluoroacetic acid and piperidine. The acetyl group on this compound makes it soluble in water, which allows for its use in pharmaceuticals and other applications.

B-Estradiol 3-(β-D-glucuronide) sodium salt is a conjugate of estradiol and glucuronic acid. Estrogens are hormones that regulate the development and maintenance of female external genitalia, secondary sexual characteristics, and reproductive function. B-Estradiol 3-(β-D-glucuronide) sodium salt is a metabolite of estradiol. It has been shown to be effective in wastewater treatment plants for the removal of estrogenic compounds from wastewater. This compound has also been validated for monitoring 17β-estradiol with high sensitivity and specificity. The enhanced detection limit of this compound can be used to monitor estrone levels in environmental samples.

Difucosyl-para-lacto-N-neohexaose is an extracellular, acidic oligosaccharide with a lactose backbone and two fucoses attached to the 2' position. Difucosyl-para-lacto-N-neohexaose is found in human milk and has been shown to be a potent inhibitor of the lectin anagyroides. Difucosyl-para-lacto-N-neohexaose is composed of tetraoses linked by α(1→4) glycosidic bonds. The linkage between the first two sugars of each tetraose can be either α(1→6) or β(1→3). The linkage between the second two sugars in each tetraose can be either β(1→4) or α(1→6). This linkage pattern restricts the possible structures to six different types,

D-Galactose-2-D is an anticancer agent that has been shown to inhibit the activity of kinases, which are enzymes involved in cell signaling pathways. It is a derivative of D-galactose and has been found in human urine. D-Galactose-2-D has demonstrated potent antitumor effects against various cancer cell lines, including Chinese hamster ovary cells and human colon carcinoma cells. This compound induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of key proteins involved in cell survival. Additionally, D-Galactose-2-D has been found to be a potent inhibitor of capsaicin-induced activation of kinase, suggesting its potential as a therapeutic agent for inflammatory conditions.