Glycoscience

<p>D-Glucose is a sugar that is used in the production of polysaccharides and glycosylations. It can be modified with fluorination, saccharide methylation, or glycosylation. D-Glucose can be synthesized by the custom synthesis of an oligosaccharide. This product has high purity, and is both monosaccharide and complex carbohydrate.</p>

Detergent used for the solubilization of membrane proteins.  Important for the solubilization is the detergent-to-protein ratio. At low ratios (1:10) the membranes are lysed and large complexes of are formed containing protein, detergent, and membrane lipids. With progressively larger ratios smaller complexes are obtained. Finally, at ratios of 10:1 to 20:1 individual detergent-protein complexes are formed free of membrane lipids. To determine the optimal conditions it is important to vary both the detergent and the protein concentration (EMBL).

<p>N-Acetyl-D-glucosaminitol is a fatty acid that is found in blood group antigens. It has been shown to be a potent inhibitor of human liver serine proteases, with an IC50 of 10 μM and a Ki value of 1.6 μM. N-Acetyl-D-glucosaminitol also inhibits the terminal steps in glycolysis and can be used as a substrate for glycosidases. It is capable of forming oligosaccharides with terminal residues and can be analyzed using titration calorimetry. The molecular weight of N-acetyl-D-glucosaminitol is calculated to be 398 Da by nmr spectroscopy. Structural analysis shows that this compound contains monoclonal antibodies and sugar residues, which are important for its function.</p>

Ixoroside is a coumarin derivative that has been shown to inhibit the activity of an enzyme called epidermal growth factor receptor. The chemical diversity of this compound has made it difficult to study its biological properties and mechanisms. Ixoroside has been studied in vitro for its effects on eye disorders and for its potential to be used as a monoclonal antibody. It has also been shown to have toxicological studies with no significant adverse effects observed. Ixoroside is found in the genus Nepeta, where it is mainly found in Nepeta cataria and Fructus ixorii species plants, which are used in traditional Chinese medicine. It can also be found in other plants such as Eucalyptus globulus, which is commonly used in cough suppressants.

(3R, 4S,5R) -3-O-Benzhydryloxybis(trimethylsilyloxy)silyl 1-benzyl-4,5-O-isopropylidene-3, 4, 5-piperidinetriol is a high purity methylated oligosaccharide. It is synthesized using Click chemistry and fluorination. This product can be modified with different functional groups. It is an excellent candidate for glycoprotein analysis due to its high purity and modification capabilities.

<p>A functionalized carbohydrate that serves as a valuable precursor for the synthesis of complex glycoconjugates, oligosaccharides, and glycopolymers through reactions like glycosylation and click chemistry</p>

3,4-Di-O-methyl-D-glucose is a partially protected glucose .It is found in the exudates of certain plants.

<p>methyl ether of glucose with the anomeric position free.</p>

Methyl 4,6-O-benzylidene-2,3-di-O-methanesulfonyl-a-D-glucopyranoside is a glycosylation product that can be used in the synthesis of complex carbohydrates. It is also useful in the synthesis of saccharides, oligosaccharides, and monosaccharides. This product is custom synthesized to order and is available in high purity.

<p>2,3,4,6-Tetra-O-acetyl-a-D-thiomannopyranse sodium salt is a synthetic compound that is used as an intermediate in the production of glycosaminoglycans. It is a complex carbohydrate with four mannose units and two acetyl groups. This compound can be methylated, fluorinated, or modified with click chemistry to produce various derivatives. 2,3,4,6-Tetra-O-acetyl-a-D-thiomannopyranse sodium salt has been shown to have antiviral and anti cancer properties and can be custom synthesized for specific needs.</p>

1,2:4,6-Di-O-isopropylidene-a-L-sorbofuranose is a synthetic glycoside that can be used as a carbohydrate in the synthesis of oligosaccharides and polysaccharides. It can be methylated at the C1 position to form 1,2:4,6-di-O-methylidene-a-L-sorbofuranose and then glycosylated with various saccharides at the O3 position. Fluorination of this compound at the C2 position yields 1,2:4,6-diO-(trifluoromethyl)idenea L sorbofuranose. This product has a melting point of 178°C.

Canagliflozin is an oral diabetes drug that belongs to the class of sodium-glucose cotransporter 2 (SGLT2) inhibitors. It works by blocking reabsorption of glucose in the kidney, thereby lowering blood sugar levels. Canagliflozin has been shown to be a potent inhibitor of insulin resistance and has been used clinically in combination with metformin hydrochloride. The chemical stability of canagliflozin is dependent on its particle size, which can range from 10 micrometres to 100 micrometres. A number of analytical methods have been developed for canagliflozin, including high performance liquid chromatography with ultraviolet detection, gas chromatography with mass spectrometry detection, and dihedral angle analysis. Canagliflozin is an example of a polymorphic compound: it exists as two enantiomers due to chiral symmetry.

4-Methoxyphenyl 4-O-(2,4,6-tri-O-acetyl-3-O-allyl-b-D-galactopyranosyl)-3-O-allyl-b-Dglucopyranoside is a synthetic sugar with a molecular weight of 532. This product can be used in the synthesis of oligosaccharides and monosaccharides. It is also used as an intermediate in glycosylation reactions. This product has not been assigned a CAS number yet.

(2S, 3S, 4S, 5S) -3, 4- Dihydroxy- 5- (hydroxymethyl) - N- methyl- 2- pyrrolidinecarboxami de is a custom synthesis of an oligosaccharide. It is a complex carbohydrate that can be modified to the customer's specifications. The product is available in high purity and with good monosaccharide and methylation yield. The chemical structure of this product contains a fluorinated saccharide.

2-Deoxy-L-ribose-anilide is a chemical compound that has been patented for its use in the detection of magnetic fields. The patent claims that this compound can be used as an intermediate in the preparation of other compounds. 2DRA has different transition temperatures, depending on whether it is in the solid or liquid state. When 2DRA is heated, it changes from a colorless liquid to a yellow crystal at around 100°C and then becomes a white solid at around 150°C. The magnetic properties of 2DRA arise from its ability to form strong bonds with other molecules, which are broken by external magnetic fields.

Benzyl 2-acetamido-2-deoxy-4,6-O-isopropylidene-b-D-glucopyranoside is a surfactant that is used in the measurement of polymers. It is soluble in water and has a low concentration. This surfactant can be used as a copolymer with terephthalate to form polyurethane foam. Benzyl 2-acetamido-2-deoxy-4,6-O-isopropylidene b -D -glucopyranoside also has high concentrations for sedimentation and sulfonate properties.

<p>Inhibitor of sialyltransferases</p>

<p>1-deoxy-D-psicose is a deoxy sugar that can be used as a reagent for the conversion of 1-deoxy-d-fructose to d-psicose. It is useful in the synthesis of rhamnose, which is a precursor to pharmaceuticals and agrochemicals. 1-Deoxy-D-psicose can be used in the synthesis of l-rhamnose from d-psicose or vice versa. This process of converting one epimer to another isomerization is very efficient, with an 88% yield.</p>

D-Mannose-6-phosphate disodium salt hydrate (DMDSP) is an endogenous pentose phosphate metabolite that is found in the human body. DMDSP is generated from the metabolism of mannose and glucose and functions as a regulator of metabolic intermediates. It has also been shown to inhibit bacterial growth and function as a competitive inhibitor of bacterial DNA gyrase, an enzyme that maintains the integrity of bacterial DNA. Genetic polymorphism in the DMDP gene may be associated with changes in response to DMDSP. The reductive amination reaction can be used to synthesize this compound from L-aspartic acid, malic enzyme, and nicotinamide adenine dinucleotide phosphate.

<p>(2S,3R,4R,5S)-5-Acetylamino-3,4-dihydroxy-2-formylpiperidine is a custom synthesis that can be modified to meet your needs. It is a fluorinated complex carbohydrate and has been shown to have high purity. The modification process of this chemical is simple and can be done in either the lab or in the field. (2S,3R,4R,5S)-5-Acetylamino-3,4-dihydroxy-2-formylpiperidine is synthesized by methylation of 5-(acetylamino)piperidinone with diazomethane followed by protection of the amine group with an acetyl group. This chemical also has Oligosaccharide and Polysaccharide properties.</p>

N-Benzyl-3,5-dideoxy-3,5-imino-1,2-O-isopropylidene-L-lyxofuranose is a compound that belongs to the group of complex carbohydrates. It is a monosaccharide with a molecular weight of 538.32 g/mol and a CAS number of 1607741-34-8. This product has been custom synthesized for research purposes. The purity level is high and it can be used in glycosylation reactions.

2-Acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-4,6-di-O-acetyl-2,6 -deoxy--a-,D-,galactopyranosyl--Fmoc--L--threonine tert--but yl ester is a synthetic carbohydrate that contains 2 acetamido groups and 3 O-(2,3,4,6 tetra O acetyl b D galactopyranosyl) groups. The chemical name for this compound is 2 Acetamido 3 O (2 3 4 6 tetra O acetyl b D galactopyranosyl) 4 6 di O acetyl 2 deoxy a D galactopyranosyl Fmoc L threonine tert but yl ester. It has been synthesized by the Click modification reaction of an oligos

<p>3,6-Anhydro-D-galactose is a monosaccharide of D-galactose where the 3 and 6 positions are cyclised in an ether link. 3,6-Anhydro-D-galactose is found naturally occurring in Rhodophyta (Red Algae) and is a constituent of the sulphated polysaccharide PLS, which has shown anti-inflammation activity and anti-nociceptive effects. In addition, sulphated polysaccharide is capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) and HIV-1.<br>We also offer this product in 10% aqueous solution (MA07897).</p>

<p>2-Acetamido-2-deoxy-5-thio-D-glucose is a custom synthesis product. It is an oligosaccharide or polysaccharide that is modified with a fluorine atom in the 2 position of the sugar. This modification can be done either by Click chemistry or by chemical oxidation. The modification of 2-acetamido-2-deoxy-5-thio-D-glucose makes it useful as a fluorescence probe for probes and as a fluorescent dye.</p>

<p>This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.</p>

Benzyl 4-O-b-D-galactopyranosyl-b-D-xylopyranoside is a glycoside that is used in the synthesis of antibiotics. It can be found in the leaves of "Ajania cordata" and "Chenopodium ambrosioides".

Ethyl 2,3,4,6-tetra-O-benzyl-b-D-thiogalactopyranoside is a synthetically produced saccharide typically used as a building block in oligo-saccharide synthesis.

<p>Please enquire for more information about N-Acetyl-D-mannosamine - low endotoxin grade including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>The main cell-wall components of baker’s yeast (Saccharomyces cerevisiae) as well as β-glucan are mannans with an α-1,6 mannose backbone and α-1,2 and α-1,3 mannose branches.<br>The image was kindly provided by Dr. Chris Lawson.</p>

Dermatan sulphate is a glycosaminoglycan found in skin, blood vessels, heart valves, tendons, aorta, spleen and brain and is usually isolated from pig skin or beef lung tissue. The disaccharide repeat unit is composed of L-iduronic acid and N-acetyl-galactosamine-4-sulphate linked β-(1,3) and β-(1,4). There are also small amounts of D-glucuronic acid.

Pustulan is a β-1,6-glucan isolated from Lasallia pustulata MW (20 kDa). It is recognized by the membrane bound Dectin-1, a C-type lectin-like pattern recognition receptor. Detection of β-glucans by Dectin-1 receptor leads to the CARD9-dependent activation of NF-κB and MAP kinases.  Studies have shown that pustulan can stimulate innate immune responses, inducing heat shock protein expression, eliciting phagocytosis, and production of pro-inflammatory cytokines. The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.

<p>2,6-Dideoxy-D-arabino-hexose is a hydrogenolysis product of 2,6-dideoxy-D-ribo-hexose. It has been shown to have a solvolytic activity and can be used for the dehalogenation of several halogenated compounds. 2,6-Dideoxy-D-arabino-hexose is also stereoselective and can be used as an estimator in population genetics. This sugar is also regulatory, catalytic, and crystalline. It is found in many carbohydrates, including weighting disaccharides such as sucrose.</p>

Sucrose octabenzoate is a practically colorless, odorless, transparent, glass-like material which is compatible with a number of synthetic resins, such as polyvinyl chloride, vinyl chloride-vinyl acetate copolymer, polyvinyl acetate and cellulose acetate. Sucrose octabenzoate improves the hardness and gloss of these products and has also been found to be useful as a component of inks, adhesives, coatings and plastic objects.

2,3,6,2',3',6',2'',3'',4'',6''-Deca-O-acetyl-a-D-cellotriosyl bromide is a glycosylation reagent that can be used in the synthesis of polysaccharides and oligosaccharides. It contains a reactive functional group at the 2 position and a reactive functional group at the 3 position. This product can be custom synthesized to meet your needs. It has been shown to react with various saccharide units, including methylated sugars such as cellobiose and erythrose. The purity of this compound is >99%.

Methyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a lectin that binds to the terminal galactose of b-D-galactopyranosides. It has been shown to be a potent inhibitor of cellular death and is able to bind to the surface of cells, preventing their destruction by the immune system or other natural factors. The binding site for MGA is found on cell membranes, and it can also act as an antiinflammatory agent. MGA has also been shown to inhibit interactions between proteins, which may lead to changes in protein synthesis and regulation. Lectins are proteins that bind to specific carbohydrates on the surfaces of cells. They are part of a group called glycoproteins and are often used as probes in techniques such as lectin histochemistry and immunohistochemistry.

<p>1,3,4,6-Tetra-O-acetyl-b-D-mannopyranose is a radiopharmaceutical that is used to diagnose and evaluate malignant tumors. It is a diagnostic agent for the detection of cancerous cells in patients with suspected cancer. The molecule emits gamma radiation when it decays. This product has been tested in experimental studies on animals and humans with tumors. There are no known side effects or interactions with other drugs. 1,3,4,6-Tetra-O-acetyl-b-D-mannopyranose can be administered intravenously or orally and can be used to detect cancerous cells in the stomach and small intestine.</p>

<p>Isopropyl 2-acetamido-2-deoxy-α-D-glucopyranoside is a modification of an oligosaccharide. It has been synthesized and characterized by NMR spectroscopy. This carbohydrate is custom synthesized as a complex carbohydrate. It is also a synthetic carbohydrate. Isopropyl 2-acetamido-2-deoxy-α-D-glucopyranoside is used as a monosaccharide, in glycosylation, methylation, polysaccharides, and other sugar chemistry reactions. Isopropyl 2-acetamido-2-deoxy-α-D-glucopyranoside can be used for fluorination or saccharides.</p>

This gamma-cyclodextrin (γ-CD) derivative is a modified cyclic oligosaccharide composed of eight glucose units, featuring a larger cavity size than α- and β-cyclodextrins. This structural characteristic allows γ-CDs to form inclusion complexes with a wider range of guest molecules, making it particularly versatile in various industries. In the food sector, it is used as a carrier and stabilizer for flavors, fat-soluble vitamins, and polyunsaturated fatty acids, protecting volatile compounds from evaporation. In pharmaceuticals, it enhances the solubility and bioavailability of poorly water-soluble drugs and, thanks to its larger ring size, allows for the encapsulation of larger molecules or even entire drug molecules. γ-CDs and derivatives are also used for environmental remediation and, in analytical chemistry, for the extraction and concentration of target substances.

Hexahydro-1,2,8-trihydroxy-[1S-(1a,2a,8a,8ab)]-5(1H)-indolizinone is a custom synthesis of a complex carbohydrate. It is an Oligosaccharide and Polysaccharide. The saccharide Methylation and Glycosylation are the Modification of this molecule. This product has CAS No. 96625-36-4 and Click modification is Carbohydrate sugar. This product is highly pure with Fluorination Synthetic

Methyl a-L-acosamine is a glycosylation agent that can be used to modify complex carbohydrates. It can also be used in the methylation of saccharides, polysaccharides, and sugars. Methyl a-L-acosamine is made by reacting acetic anhydride with L-a-D-galactopyranosyl chloride. The CAS number for this product is 54623-23-3. This product can be custom synthesized to meet your specifications and has high purity.

<p>2,3,4,6-Tetra-O-acetyl-b-D-thiogalactopyranose is a synthetic sugar that is prepared by the fluorination of D-galactopyranose and subsequent acetylation. This compound can be used for glycosylation reactions and as a substrate for click chemistry. It is an oligosaccharide with four monosaccharides in its backbone. The CAS number of 2,3,4,6-Tetra-O-acetyl-b-D-thiogalactopyranose is 50615-66-2.</p>

<p>Epsilon-cyclodextrin (ε-CD) consists of 10 glucose units. Its larger cavity size offers potential for encapsulating larger guest molecules or forming more complex inclusion compounds.</p>

<p>tert-Butyl b-D-glucopyranoside is a monomer that belongs to the class of acrylic acid ester. It is used in polymer synthesis, as a photoinitiator and as a light stabilizer for polymers. The compound is resistant to heat and has a high degree of light transmittance. Tert-butyl b-D-glucopyranoside is soluble in chloroform and can be found in carbon tetrachloride solution with a transmittance of up to 83%. This compound can be used as an indexing agent for silicon wafers because it produces protrusions when immersed in chloroform.</p>

<p>Dextran is a polysaccharide that is used as an antimicrobial agent and as a volume expander in the treatment of bowel disease, myocardial infarct, and other diseases. Dextran sulfate is a linear polymer with a molecular weight of 500,000 to 1,000,000. It has minimal toxicity and does not interfere with iron homeostasis or cause fluid overload. Dextran sulfate can be used for the treatment of bowel disease because it has been shown to have anti-inflammatory effects in experimental models. The mechanism by which dextran sulfate inhibits inflammation is unknown, but may involve its ability to bind to macrophages and neutrophils in the gut wall. Dextran sulfate also binds to bacteria and prevents their growth. This binding may prevent bacterial penetration into epithelial cells or block bacterial attachment to cell surfaces. The efficacy of dextran sulfate against pathogenic mechanisms such as inflammation has been demonstrated in experimental models.</p>

<p>(1R) -1- [(2S, 3R) - 3- Hydroxy- 1- butyl - 2- azetidinyl] -1, 2- ethanediol is a glycosylase that catalyzes the hydrolysis of terminal sialic acid residues from oligosaccharides and monosaccharides. It is used in the synthesis of complex carbohydrates. This glycosylase has been shown to be highly specific for terminal sialic acids and can also be used to produce oligosaccharides with desired linkages between the sugars. The enzyme is most active at low pH and high temperatures.</p>

<p>4,6-O-Benzylidene-D-galactose is an anomer of D-galactose. It is a lectin that has been shown to inhibit the binding of amyloid beta to the cerebroside in the brain tissue. This activity may be due to its ability to form an amide bond with galactose, which is present in amyloid beta. 4,6-O-Benzylidene-D-galactose also has a coronary heart disease prevention effect and can help reduce cholesterol levels. Furthermore, it has been found to have anti-cancer properties and can help prevent the growth of cancerous cells by inhibiting protein synthesis. In addition, 4,6-O-Benzylidene-D-galactose can be used as a cationic surfactant or detergent composition for cleaning or treating surfaces.</p>

2-Acetylamino-3,4-O-benzylidene-2-deoxy-D-arabino-1,4-lactone is a synthetic compound that is used to modify the carbohydrate chains in Glycopeptides. This modification can be done by either fluorination or methylation. The click modification has been shown to be effective for complex carbohydrates such as oligosaccharides and polysaccharides.

a-L-Galactose-1-phosphate dipotassium salt is an oligosaccharide that can be prepared by the methylation of a galactose molecule. It is a synthetic compound that has been shown to have antiviral properties. The modification of the sugar structure with fluorine atoms increases the stability of the molecule and prevents its degradation. This product is soluble in water and can be used as a pharmaceutical intermediate for other compounds.

<p>Starch component; highly branched glucan</p>

Apogossypol is a polyunsaturated fatty acid that has been shown to have anticancer and anti-inflammatory properties. Studies have shown that apogossypol inhibits the production of proinflammatory cytokines and nitric oxide, which are compounds that can cause inflammation. Apogossypol also has been shown to inhibit apoptosis in cancer cells, which is a programmed cell death process. Apogossypol may be useful as an anticancer agent due to its ability to induce apoptosis and inhibit inflammation in cancer cells.