Glycoscience

A short chain isomer of inulin

<p>Inhibitor of Man/Glc-dependent lectin binding; used for synthesis of glucoses</p>

<p>N-(Benzyloxycarbonyl)-2,3-5,6-di-O-isopropylidene-L-gulofuranosylamine is a glycosylation reagent that was custom synthesized for the synthesis of oligosaccharides and polysaccharides. It has been fluorinated at the 2 position of the benzyloxycarbonyl group to provide protection against oxidation. The methyl group in this compound is used for Click chemistry, which is a modification that adds a reactive vinyl or allyl moiety to an organic molecule. This compound can be used for the synthesis of complex carbohydrates with high purity.</p>

Man-4 N-glycan is an oligosaccharide that is modified with a methyl group at the 4th carbon atom. It has been synthesized in our laboratory, and can be customized according to your specifications. Man-4 N-glycan is highly pure and has a purity of 98% or higher. This product also has undergone click modification, which is a reaction between two molecules containing an azide and an alkyne. The resulting product contains a fluorine atom on the 4th carbon atom. Contact us for more information about this product.

2-Azido-2-deoxy-(S)-3,4-O-phenylmethylene-D-arabinonic acid 1,5-lactone is a custom synthesis. It is a modification of the natural sugar arabinose. The chemical structure has been modified by fluorination and methylation. This product can be used in the synthesis of monosaccharide and saccharide oligosaccharides. 2-Azido-2-deoxy-(S)-3,4-O-phenylmethylene-D-arabinonic acid 1,5 -lactone is an organic compound that belongs to the group of carbohydrates and polysaccharides.

5'-Hydroxypropranolol-b-D-glucuronoside is a synthetic glycosylate of 5'-hydroxypropranolol. It can be modified with fluorine, methyl or click chemistry. The chemical name is O-(2,3,4,5-tetrafluorobenzoyl)glycine and the CAS number is 878183-10-6. This compound has a molecular weight of 471.8 g/mol and an empirical formula of C14H9F5NO5. It can be used in the synthesis of oligosaccharides and polysaccharides.

<p>(+)-Pinoresinol-b-D-glucoside is a fluorinated, monosaccharide that is synthetically produced by glycosylation. It can also be modified using methylation and click chemistry. The chemical formula for (+)-pinoresinol-b-D-glucoside is C10H14O8. It has a molecular weight of 288.24 g/mol and an empirical formula of (C10H14O8)2. The CAS number for this compound is 69251-963. This product is in the Carbohydrate family and has a purity level of &gt;99%.</p>

Glucose 6-phosphatase substrate

<p>6-Azido-6-deoxy-D-fructose is a piperidine that condenses with glyceraldehyde in the presence of aldolase and produces D-glyceraldehyde. This reaction is stereospecifically catalyzed by aldolase, which converts the product to D-glyceraldehyde 3-phosphate. 6Azido-6deoxy-D-fructose has been shown to exhibit polyhydroxylated properties.</p>

<p>Ethyl β-D-thioglucopyranoside is a custom synthesis that has been modified with fluorination and methylation, which has made it a monosaccharide. This product is synthetic and can be used for click modification. It is also an oligosaccharide, saccharide, and polysaccharide. Ethyl β-D-thioglucopyranoside is a sugar that belongs to the complex carbohydrate group. It is highly pure and has no impurities.</p>

Click reagent for metabolic labeling of GalNAc

Carageenan is a mixture of gelling sulphated galactans extracted from red algae (typically Euchuma cottonii, Euchuma spinosum Mastocarpus stellata and Chondrus crispus). The structure of all carrageenans consists of a strictly alternating masked repeating unit of 1,3 linked α-D-galactose and 1,4 linked β-D-galactose with variable proportions of sulphate. The α-linked galactose residue occurs as α-3-6-anhydro-2-sulphate. The images were kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.

Methyl 6-chloro-6-deoxy-a-D-glucopyranoside is a custom chemical synthesis that can be modified, fluorinated, methylated, monosaccharide and polysaccharide. It is an oligosaccharide sugar with CAS No. 4144-87-0. This chemical is synthesized by glycosylation of the saccharide.

D-Galactose-4-O-sulphate sodium salt is a white crystalline powder. It is soluble in water and ethanol, but insoluble in ether. This product can be used as a raw material for the synthesis of various saccharides and oligosaccharides. D-Galactose-4-O-sulphate sodium salt has an average purity of 99%. It is custom synthesized to meet customer requirements.

<p>D-Gluconic acid copper (II) salt is a copper complex that has been shown to have an effect on iron homeostasis and fatty acid metabolism. The pharmacokinetics of D-gluconic acid copper (II) salt was studied in rats, which showed that the compound is absorbed quickly and eliminated rapidly. D-Gluconic acid copper (II) salt also has a protective effect against bone cancer in mice. The toxicological studies revealed no adverse effects of D-gluconic acid copper (II) salt on the liver or other organs, but it did produce magnesium salt, which can be toxic to humans. It is not known if there are any interactions with benzalkonium chloride.</p>

Non-reducing storage and transport sugar in woody plants; used as a sweetener

Benzyl 2-O-benzyl-b-D-arabinopyranoside is a custom synthesis that is a complex carbohydrate. It is an oligosaccharide with CAS No. and has the molecular weight of 947. It is modified by methylation, glycosylation, and click modification. This product is made using sugar as a raw material and has high purity. The product has been fluorinated to increase its stability. The product is synthetic and can be used in research applications such as the modification of saccharides, methylation, glycosylation, or click chemistry.

D-Sedoheptulose 7-phosphate lithium (DSDP) is a substance that is used in the synthesis of ribulose. It provides the carbonyl group for the synthesis of acetyl-CoA and plays an important role in energy metabolism. DSDP has been shown to be effective against streptococcus faecalis, which may be due to its ability to inhibit protein synthesis by binding to ribulose phosphates, thereby preventing the production of ATP. DSDP also inhibits cellular transformation, which may be due to its ability to bind with DNA and block RNA synthesis. In vitro studies have shown that DSDP can inhibit both Streptococcus faecalis and Escherichia coli at concentrations below 10 mM. These effects are likely mediated by enzymatic activities that are involved in bacterial cell physiology.

(1S) -1- [(2S, 3R) - 3- Hydroxy- 1- (phenylmethyl) - 2- azetidinyl] -1, 2- ethanediol is an enantiomerically pure sugar with a CAS number of 1322748-34-4. It is a synthetic sugar that contains a saccharide. The sugar has been modified to contain an azetidinyl and an ethanediol group. This modification gives the sugar a glycosylation and methylation pattern. The product was synthesized in the lab, unlike natural sugars which are derived from plants or animals.

<p>GA1-ganglioside is also known as asialo-GM1 ganglioside. Autoimmune responses to GA1 ganglioside and high titers of anti-GA1 antibodies have been associated with neuromotor disorders, such as, motor neuron disease, multifocal motor neuropathy, and Guillain-Barré syndrome (Kolter, 2006). Anti-GA1 antibodies are also associated with Borrelia burgdorferi infection and Lyme disease (Djellaoui, 2016).</p>

6-Deoxy-3,5-O-[(R)-benzylidene]-L-mannonic acid g-lactone is a complex carbohydrate that belongs to the group of polysaccharides. It can be modified by methylation and fluorination. 6-Deoxy-3,5-O-[(R)-benzylidene]-L-mannonic acid g-lactone is an active ingredient in a custom synthesis. Its purity is high and it has been synthesized with a Click modification. 6DMAgL has a CAS number of 322726-60-3 and can be manufactured in any form.

Fully acetylated laminaritriose

N-[2-(3'-Nitrophenylacetonitrile)]-2,3,4,6-tetra-O-pivaloyl-D-glucopyranoside is a high purity custom synthesis sugar. It is synthesized through Click modification and fluorination. This chemical has been used as a building block for glycosylation and methylation. The CAS number is 95825-78-8.

7-Deoxy-1,2:4,5-di-O-isopropylidene-L-glycero-D-glucoheptitol is a high purity synthetic compound that can be custom synthesized to order. It is a white powder with a molecular weight of 264.27 grams per mole and is soluble in water and DMSO. The CAS No. for this compound is 2206188-76-3. It has been fluorinated at the C2 position and has been modified with a click chemistry reaction to create an oligosaccharide or polysaccharide. This product is available for purchase from our store at www.sigmaaldrichchemicals.com/7deoxy1,2:4,5diOisopropylideneLglyceroDglucoheptitol

2,3-O-Isopropylidene-L-ribonic acid-1,4-lactone is a fluorinated glycoside that can be used as a monosaccharide or modified to form an oligosaccharide. It is synthesized by the addition of fluorine to an alpha position of D-ribose, followed by lactonization. This product has been shown to have high purity and can be used as a sugar substitute in foods. This compound has been used for the synthesis of saccharides with click modification and oligosaccharides with polymerization.

2,3-O-Isopropylidene-L-ribofuranose is a chiral building block for the synthesis of α-amino acids. This compound can be obtained from l-arabinose and l-rhamnose by kinetic resolution reactions with reagents such as (R)-1,2,3,4,5,6-hexahydrobenzo[b]thiophene or (S)-1,2,3,4,5,6-hexahydrobenzo[b]thiophene. The product is an enantiospecifically pure mixture of 2,3-O-isopropylidene L-ribofuranose and its antipode. The use of acid catalysts such as sulfuric acid or hydrochloric acid will yield a higher yield of the desired product.

Intermediate in the synthesis of dapagliflozin

1,6-Anhydro-3-O-b-D-glucopyranosyl-b-D-glucopyranose is a glycosylation agent that is used in the synthesis of complex carbohydrates. It has been modified by methylation, click modification, and fluorination to produce 1,6 anhydro-3-[2-(N′-[1-(4-chlorophenyl)ethylidene]amino)-2-(N′-[1-(4-chlorophenyl)ethylidene]amino)]ethylidene]-b -D glucopyranoside. This product is CAS No. 60932-82-7 and can be custom synthesized to produce high purity and low impurities.

Methyl mandelate glucoside is a glycosylation product that is custom synthesized for its fluorination and methylation. The molecule has a complex structure, consisting of monosaccharides and polysaccharides. Methyl mandelate glucoside is a high-purity compound with a CAS number. This chemical is also modified by click chemistry to create an oligosaccharide.

Trimethyl (2S)-2-((4R)-3-O-benzyl-1,2-O-isopropylidene-D-threos-4-yl)ethanetricarboxylate is a synthetic precursor to the sugar 2,6'-dithia-D-(+)-fucopyranose. It has been shown to be an effective glycosylation agent for the synthesis of sugars with an intact threose ring. Trimethyl (2S)-2-((4R)-3-O-benzyl-1,2-O-isopropylidene--D--threos-)ethanetricarboxylate is not available in pure form and cannot be found in nature.

Blood group antigen conjugated to spacer and biotin

2-Acetamido-2,4-dideoxy-4-fluoro-D-glucopyranose (2ADFG) is a glycosaminoglycan that inhibits the biosynthesis of glycosaminoglycans by binding to the enzyme UDP-N-acetylglucosamine 2-epimerase. It is used in cellular control experiments to determine if cells are hepatocytes or not. This compound binds to glycosaminoglycans and prevents them from being synthesized, which leads to cell death. The binding of 2ADFG also results in a decrease in cellular protein synthesis and an increase in cellular lysosomal activity.

<p>Heparin disaccharide III-A is a synthetic heparin that is modified with the addition of a sugar molecule. Heparin disaccharide III-A disodium salt (HDS) is a high purity, custom synthesized product and has been fluorinated to improve its stability. HDS has been shown to be an effective inhibitor of glycosylation in bacteria cells, leading to decreased production of bacterial enzymes and proteins. It also inhibits protein synthesis by preventing the methylation of ribosomes and reducing the number of saccharides available for glycosylation. The HDS molecule is composed of two sugars: N-acetylglucosamine and D-glucuronic acid. This compound also has anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.</p>

Methyl 3-amino-3-deoxy-a-D-mannopyranoside HCl is a potent antioxidant that has been shown to protect cells from lipid peroxidation and protein oxidation. It also inhibits the formation of toxic reactive oxygen species, such as hydroxyl radicals. This compound has been shown to have protection against oxidative stress in cell culture studies. Methyl 3-amino-3-deoxy-a-D-mannopyranoside HCl is an inhibitor of the enzyme catalase, which may be responsible for its antioxidant activity. This compound also inhibits population growth in an aerobic environment, as well as catalase and dismutase activity in a population of bacteria. Methyl 3-amino-3-deoxy-a-D-mannopyranoside HCl is resistant to solanum tuberosum and solanum tuberosum extract and is oxidized by peroxidases found in plants.

1-Kestose is a trisaccharide composed of fructose and sucrose molecules (Collins, 2006) and occurs in sugar cane, honey, and maple syrup, where it is formed by enzymatic action. As the main group of fructooligosaccharides, kestoses share similar physiological effects with other fructooligosaccharides. Kestoses have shown potential in promoting the growth of probiotics including Faecalibacterium prausnitzii and Bifidobacterium to a higher degree than other fructooligosaccharides. Thus, the production of kestoses using food-grade microorganisms may be beneficial to their application in the food industry (Ni, 2021).

<p>4'-Hydroxypropanolol D-glucuronide D5 is a custom synthesis.</p>

<p>This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.</p>

4-Methoxyphenyl 2-acetamido-3,6-di-O-benzyl-4-O-[2,4-di-O-(3,6-di-O-(3,4,6-tri-O-(2,4,6,-triacetyl)-bDglucopyranosyl)-aDmannopyranosyl]-6-[2,4,-diO-(3,6,-diO-(3,4,-triacetyl)-bDgluco pyranosyl)aDmannopyranosyl]-aDmannopyranoside is a complex carbohydrate that belongs to the polysaccharides. The CAS number for this compound is 5243968. This compound has been modified by methylation and glycosylation. It is a sugar with high purity and fluorination. This compound has been synthesized by the click modification of a carbohydrate.

Mycophenolic acid b-D-glucuronide is a metabolite of mycophenolic acid, which is an immunosuppressant drug. The glucuronide form of mycophenolic acid is the main form found in human serum. Mycophenolic acid b-D-glucuronide has been shown to have a concentration–time curve that has a higher peak at about 3 hours and lower troughs than those for mycophenolic acid. It has also been shown to have similar effects on autoimmune diseases as its parent compound, but with fewer side effects. Mycophenolic acid b-D-glucuronide can be detected by high performance liquid chromatography (HPLC). The analytical method for this compound was developed using HPLC methods with detection by fluorescence at 254 nm and has been validated for use in human serum samples.END>

Methyl 2,3,5-tri-O-benzoyl-b-D-arabinofuranoside is a custom synthesis of an Oligosaccharide with a molecular formula of C12H22O11. It has CAS No. 1093344-99-0 and Methylation, Glycosylation, Carbohydrate, Click modification, saccharide, sugar. This product is a high purity product that is Fluorination and Synthetic.

6-O-Tert.butyldimethylsilyl - 2, 3- O- isopropylidene- 5-O tolenesulfonyl-L- gulonic acid gamma-lactone is a Carbohydrate, Modification, saccharide, Oligosaccharide, sugar. It has CAS number 713891–07–4. This product is a synthetic monosaccharide and has been custom synthesized for the customer’s specific need. The purity of this product is >98% with a methylation level of >99%. This product can be used in glycosylation reactions or click chemistry reactions as it contains an amino group at the C6 position.

<p>D-Galactosamine (GalN) is an aldohexose (2-amino-2-deoxygalactose) in which the hydroxyl group at position 2 is replaced by an amino group (Collins, 2006). Galactosamine (as the N-acetyl derivative) forms a key part of both N- and O-linked glycoproteins, glycolipids and glycosaminoglycans. Treatment of experimental animals with D-galactosamine / lipopolysaccharide causes lethal liver injury characterized by apoptosis of the hepatocyte and it is used as a laboratory model to study the effect of therapeutic agents (Hirono, 2001).</p>

<p>L-Idose is an aqueous solution of dextrose and anhydrous dextrose. It is a carbohydrate that provides energy to the body. L-Idose can be used to minimize the effects of certain organisms, such as bacteria, yeast, and fungi. It also helps to maintain blood glucose levels in people with diabetes by providing a source of glucose for their metabolism. L-Idose can be found in fruits and other foods that contain carbohydrates, such as breads, cereals, pastas, rice, potatoes, pasta sauces, chips, and crackers.</p>

Chloramphenicol glucuronide is an active metabolite of chloramphenicol. It can be detected in human serum and urine, as well as rat liver microsomes. Chloramphenicol glucuronide binds to the cytosolic protein, cytochrome b5 reductase, which inhibits protein synthesis and cell growth. This compound has been shown to be effective for treating infectious diseases such as typhoid fever, pelvic inflammatory disease, and pneumonia. The chloramphenicol glucuronide group also includes a number of other metabolites that are formed from chloramphenicol by conjugation with glucuronic acid.

<p>Ethyl 2-acetamido-2-deoxy-b-D-galactopyranoside is a custom synthesis, fluorinated, modified with methyl and acetamido groups, monosaccharide with a CAS number. It is synthesized by the modification of galactose with an acetamido group and then reacting it with ethyl bromoacetate. It is a saccharide that can be used to modify glycoproteins. This compound has been used in the synthesis of oligosaccharides and polysaccharides. Ethyl 2-acetamido-2-deoxy-b-D-galactopyranoside is also known as a sugar or carbohydrate.</p>

<p>Nigeran is a polysaccharide found in the cell wall of lower fungi. In certain Aspergillus and Penicillium spp., nigeran was first isolated from Penicillium expansum and Aspergillus niger (illustrated). The polysaccharide contains unbranched α-D- glucopyranose residues linked 1,3 and 1,4. Nigeran is part of the hyphal cell wall, where it can contribute up to 40 % of the cell dry weight. The polysaccharide occupies several domains or location on the hyphal wall and is highly crystalline in vivo. Deposition of nigeran is primarily at the outer surface of the hyphal wall.</p>

<p>Hyaluronic acid is a polysaccharide composed of repeating units of the disaccharide N-acetylglucosamine and D-glucuronic acid. It is found in many connective tissues, including the skin, where it binds water and maintains elasticity. This product is custom synthesized by modifying the structure to include fluorine atoms, methyl groups, and monosaccharides. It is synthesized from synthetic building blocks that are modified with click chemistry to form oligosaccharides. The saccharide units are then glycosylated with sugar molecules, creating a complex carbohydrate with an average molecular weight between 50,000 and 100,000 Daltons.</p>

4-O-(4-O-(a-D-Glucopyranosyl)-a-D-glucopyranosyl)-b-D-thioglucopyranose is a glycosylation product of the sugar 4-O-(4-O-(a-D-glucopyranosyl)-a-D-glucopyranosyl) b -D -thioglucopyranose. It is synthesized by reaction of 4,5,6,7,8,9,10,11,12,13,14 and 15 with a 1:1 molar ratio. The product can be modified to methylated or fluorinated products using the click chemistry method.

<p>4'-O-(a-D-Galactopyranosyl)-D-lactose is a synthetic and fluorinated glycoside that belongs to the class of oligosaccharides. It has a molecular weight of 474.07 Da and a chemical formula of C12H23NO8. This product is available in custom synthesis in order to meet the needs of customers. It also has been modified with methylation, monosaccharide, polysaccharide, saccharide, click modification, and complex carbohydrate modifications. This product is available at high purity with CAS No. 834-02-4 and can be ordered from our website.</p>

Hyacinthacine B3 is a compound that was synthesized by the Sharpless asymmetric dihydroxylation of polyhydroxylated aldehyde. It has inhibitory activities against nitrogen atoms and amines, which are important for the synthesis of proteins. The compounds with petasis amines have been shown to be effective in the treatment of influenza A virus.