Glycoscience

Thiogalactose is a naturally occurring disaccharide that has been shown to have anti-inflammatory properties. It inhibits the production of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), and suppresses the growth of experimental colitis in mice. Thiogalactose also denatures fatty acids and prevents 3t3-l1 preadipocytes from undergoing cellular transformation. This compound also inhibits the uptake of bovine serum albumin by macrophages, which may be due to its alkylthio group. Thiogalactose has been shown to inhibit proliferation of cultured human cells, including monocytic leukemia cells, when used at concentrations less than 10 mM.

N-(7-Oxadecyl)deoxynojirimycin is a chaperone protein. It belongs to the group of proteins that are deficient in patients with type 1 glycogen storage disease and can be used to treat this condition. N-(7-Oxadecyl)deoxynojirimycin has been shown to bind to the endoplasmic reticulum, thereby preventing the maturation of certain proteins and their transport into other cellular compartments. This agent also has a protective function in muscle cells by preventing protein degradation due to abnormal folding or misfolding. The long-term effect of N-(7-Oxadecyl)deoxynojirimycin on skeletal muscle is unclear, although it has been found to be beneficial in the short term for patients with type 1 glycogen storage disease.

D-Glucuronic acid (GlcA) is D-glucose with position six oxidised to a carboxyl group (Collins, 2006). It is a common component of a number of gums and mucilages structurally related to pectins, where it is can be present as a terminal non reducing end residue (Renard, 1999). Glucuronic acid is also found in bacterial polysaccharides, such as, xanthan gum produced by Xanthomonas campestris (Faria, 2011), and in glycosaminoglycans, such as, heparan sulfate (Casale, 2020).

Component of peptidoglycan in bacterial cell walls. Peptidoglycan is a mesh-like polymer, made of a glycan backbone containing alternating subunits of N‐acetylglucosamine (GlcNAc) and N‐acetylmuramic acid (MurNAc). An enzyme substrate that is used to characterize and differentiate MurNAc and GlcNAc kinases.

6-Amino-6-deoxy-D-lactosylamine is a modified sugar that is used to synthesize glycosides. It is also used as a reagent for the methylation of saccharides and polysaccharides. This product can be custom synthesized or ordered from our catalog. We offer high purity 6-amino-6-deoxy-D-lactosylamine, which has been chemically modified with fluorine and has a CAS number of 7092-12-3. It is available in different quantities and can be ordered with other custom modifications, such as Click chemistry.

Methyl β-D-ribopyranoside is a sugar alcohol that belongs to the group of pentoses. It is a potential precursor for the synthesis of phosphite, which is a reactive anion used in organic chemistry. Methyl β-D-ribopyranoside has been shown to regulate the growth of bacteria and fungi by altering their metabolic pathways. This compound also has shown to be programmed death in certain bacterial strains, although it is not clear how it induces this programmed death. Methyl β-D-ribopyranoside can also affect the rhizosphere and can be used as a substrate for anions and sugar alcohols.

Glucose 6-phosphatase substrate

Gycosaminoglycan in many organs; joint lubricant and shock absorber

Cancer-associated carbohydrate antigen

Ziyuglycoside I is a naturally occurring compound that has been shown to have physiological effects on skin cells. It has been found to bind to collagen and the matrix of skin cells, which may be its mechanism of action. Ziyuglycoside I also has an anti-inflammatory effect, which may be due to its ability to inhibit transcription-polymerase chain reactions (PCR). It has been shown to have antimicrobial activity against some strains of bacteria that are resistant to antibiotics such as erythromycin and tetracycline. Ziyuglycoside I has potential applications in the treatment of infectious diseases and inflammatory skin diseases.

Acarviosin is a chemical compound that is structurally related to the antimicrobial peptide Ac-LLL-Nal-OH. It is an antidiabetic agent that has been shown to be effective for the treatment of type 2 diabetes and associated cardiovascular risk factors. Acarviosin was originally isolated from a bacterial strain and has been chemically synthesized for use in the treatment of diabetes. Acarviosin inhibits both glycan synthesis and enzyme activities, leading to reduced levels of glucose in blood plasma. This drug also exhibits pharmacokinetic properties with a half-life of approximately 15 hours, which allows it to be taken once daily. Acarviosin can also be used as an analytical method for identifying disaccharides by cleaving them at the glycosidic bond, releasing monosaccharides as products.

Laminaran is a polysaccharide that co-occurs with fucoidan and alginate in brown seaweeds such as Laminaria digitata, Laminaria cloustoni, Eisenia bicyclis and Thallus laminariae. It is a β-1,3-linked glucan which it is claimed stimulates the immune system in mammals and fish.
The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.

4-Methoxyphenyl 4-O-{4-O-[[2-O-Ac-3-O-[2,4-di-O-(3,4,6-tri-O-Ac-2-PhthNbDGlc)-3,6--Di--O--Bn--aDMan]-4,6--O--Benzylidene--bDMan]]} -3, 6--Di--Obn2PhthNbDGlc} -2 PhthNbDGlc is a sugar that has been modified by methylation. It also contains saccharide and polysaccharides. This product is CAS No. 899891–14–8 and can be purchased through custom synthesis. The purity of this product is high and the modification is fluorination.