Antimicrobianos

Penicillin G potassium is a natural penicillin antibiotic with action on bacterial cell wall synthesis and is used for treating severe bacterial infections like meningitis, syphilis, and endocarditis.

Penciclovir is an antiviral agent and acyclic guanine derivative that has proven efficient in the treatment of Herpes Simplex type 1 and 2 (HSV1 and HSV2) infection. Penciclovir is transformed by the virus into an active derivative able to block the deoxyguanosine triphosphate substrate binding site of the HSV polymerase.

Herbicidin K is a naturally derived herbicide, known for its biological origin from microbial fermentation processes. It is primarily sourced from certain strains of Streptomyces, a genus of Gram-positive bacteria notable for their diverse secondary metabolites. The mode of action of Herbicidin K involves the inhibition of key enzymatic pathways within target plants, leading to the disruption of cellular functions and ultimately plant death. This selectivity is particularly effective against broadleaf weeds, providing a targeted approach to weed management.

Griselimycin is an antibiotic, which is derived from the bacterial genus *Streptomyces*. This compound exhibits its mode of action by targeting bacterial protein synthesis, specifically binding to the DNA polymerase sliding clamp, thereby inhibiting replication and cell division in a range of bacterial pathogens. Griselimycin has been the focus of renewed scientific interest due to its potent activity against Mycobacterium tuberculosis, including multi-drug-resistant strains. The compound’s unique mode of action makes it a promising candidate for further development in the treatment of tuberculosis and potentially other bacterial infections that have developed resistance to more commonly used antibiotics. Advances in understanding its biosynthesis have facilitated semi-synthetic modifications, potentially enhancing its pharmacokinetic properties and antimicrobial spectrum. The applications of Griselimycin extend to research contexts where understanding resistance mechanisms and novel antibiotic development are critical. Continued exploration of this compound may contribute significantly to addressing the global challenge of antibiotic resistance.

Nucleoside analog with antiviral activity against coronaviruses, hepatitis and influenzas viruses. EIDD 1931 inhibited the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the murine hepatitis virus (MHV) replication in vitro at submicromolar concentrations. EIDD 1931 is able to evade the proofreading exonuclease ExoN and presents with high barrier to development of drug resistance.

Inhibitor of cell-wall synthesis; carbapenem class

Ribostamycin sulphate is an aminoglycoside antibiotic with action on bacterial protein synthesis by binding to the 30S ribosomal subunit and is used for treating bacterial infections like sepsis and pneumonia.

Benethamine penicillin is a beta-lactam antibiotic, which is a semi-synthetic derivative of penicillin. It is sourced from the modification of naturally occurring penicillin compounds, typically produced through the fermentation of Penicillium mold cultures. Benethamine penicillin operates by inhibiting bacterial cell wall synthesis. It targets the penicillin-binding proteins within bacterial cell membranes, disrupting peptidoglycan cross-linking, which is essential for cell wall structural integrity. This leads to cell lysis and death in susceptible bacteria.

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate is an antibacterial compound with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. It is active against strains resistant to other antibiotics, such as, tetracycline and penicillin. 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate has been shown to be effective in vitro against Campylobacter jejuni - the most common cause of bacterial gastroenteritis in humans. The compound also inhibits the growth cycle of Campylobacter jejuni by arresting the cells at the G1 phase. The molecule has been shown to inhibit DNA synthesis in E. coli and S. typhimurium with IC50 values of 1 ÎŒM and 0.8 ÎŒM respectively. This molecule has been tested for its surface active properties and it can be used as an additive in personal care products for improved wetting and spreading on surfaces. The compound is also researched for its antifungal efficacy against Candida albicans by inhibiting the growth cycle of the fungus.

Chlorotetracycline monohydrochloride is an antibiotic designed for culture media use. It is derived from the bacterium *Streptomyces aureofaciens*, and functions primarily by inhibiting bacterial protein synthesis. This action prevents the attachment of aminoacyl-tRNA to the ribosomal acceptor site, effectively halting the growth of bacteria by disrupting protein production, which is essential for their survival and replication.