Antiparasitarios
Los antiparasitarios son compuestos diseñados para tratar y prevenir infecciones parasitarias mediante la inhibición del crecimiento y la supervivencia de los parásitos. Esta categoría incluye una variedad de agentes antiparasitarios destinados exclusivamente para uso en laboratorio y no para el consumo humano. Estos productos son esenciales para fines de investigación, permitiendo a los científicos estudiar los ciclos de vida de los parásitos, los mecanismos de acción y el desarrollo de resistencia. El uso de antiparasitarios en entornos de laboratorio ayuda en el descubrimiento y la optimización de nuevos tratamientos para enfermedades parasitarias, contribuyendo a los avances en parasitología médica y veterinaria. Los investigadores dependen de estos productos para mejorar su comprensión de las infecciones parasitarias y desarrollar terapias más efectivas.
Se han encontrado 704 productos de "Antiparasitarios"
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PFK-IN-1
CAS:<p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>Fórmula:C18H15Cl2N3O4SForma y color:SolidPeso molecular:440.3Ipronidazole
CAS:<p>Ipronidazole (RO-71554) is an orally effective antiprotozoal agent used to prevent and ameliorate histomoniasis in turkeys, commonly referred to as blackhead disease.</p>Fórmula:C7H11N3O2Forma y color:SolidPeso molecular:169.18Arohynapene B
CAS:<p>Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.</p>Fórmula:C18H22O3Forma y color:SolidPeso molecular:286.366NEU-1017
CAS:<p>NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.</p>Fórmula:C33H31ClFN5O3SForma y color:SolidPeso molecular:632.147SLU-10906
CAS:<p>SLU-10906 (Compound 63) is an orally active inhibitor of Cryptosporidium. It demonstrates activity against the parasite in cell-based infection models with an EC50 of 0.19 μM and exhibits no cytotoxicity. SLU-10906 is a promising candidate for research in cryptosporidiosis.</p>Fórmula:C22H21BFN5O2Forma y color:SolidPeso molecular:417.244SPB07935
CAS:<p>SPB07935 inhibits plasmepsin II in the malaria-causing parasite Plasmodium falciparum and serves as an antimalarial agent. It affects the life cycle of P. falciparum, hindering the growth of the parasite's FcB1 and 3D7 strains, with IC50 values of 8 μM and 4.7 μM, respectively.</p>Fórmula:C22H15N5O4S2Forma y color:SolidPeso molecular:477.516Menoctone
CAS:<p>Menoctone is an orally effective antimalarial agent that inhibits blood-induced rodent malaria. It enhances the antimalarial effects of chloroquine or quinine, making it useful for malaria research.</p>Fórmula:C24H32O3Forma y color:SolidPeso molecular:368.51Insecticidal agent 16
CAS:<p>Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.</p>Fórmula:C21H13Cl2F6N5O2SForma y color:SolidPeso molecular:584.32Antimalarial agent 48
CAS:<p>Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.</p>Fórmula:C19H14F3N11Forma y color:SolidPeso molecular:453.383MMV03
CAS:<p>MMV03 is an antimalarial compound effective against Plasmodium falciparum, with an EC50 of 0.6 μM.</p>Fórmula:C19H14N4OSForma y color:SolidPeso molecular:346.406Antimalarial agent 44
<p>Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.</p>Fórmula:C37H37N5O7Forma y color:SolidPeso molecular:663.72MED6-189
CAS:<p>MED6-189, an analog of kalihinol, disrupts the apicoplast functions and vesicular transport in the malignant malaria parasite (P. falciparum, IC50 < 50 nM). The compound specifically targets the apicoplast, which is a non-photosynthetic plastid essential for isoprenoid synthesis, found in most apicomplexan parasites.</p>Fórmula:C17H26N2OForma y color:SolidPeso molecular:274.40Isazofos
CAS:<p>Isazofos is a broad-spectrum organophosphate insecticide and nematicide effective in controlling a variety of lawn pests, such as nematodes (Radopholus similis). It also demonstrates efficacy in managing rice gall midge.</p>Fórmula:C9H17ClN3O3PSForma y color:SolidPeso molecular:313.74PfCLK3-IN-1
<p>PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.</p>Fórmula:C28H27ClN4O4Forma y color:SolidPeso molecular:518.99PIQ-2
CAS:<p>PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.</p>Fórmula:C23H21F3N4O3Forma y color:SolidPeso molecular:458.43Ferrocene
CAS:<p>Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.</p>Fórmula:C10H10FeForma y color:SolidPeso molecular:186.03Erythromycin B
CAS:<p>Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.</p>Fórmula:C37H67NO12Forma y color:SolidPeso molecular:717.93SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Fórmula:C15H15FN4OForma y color:SolidPeso molecular:286.304DNA crosslinker 6
CAS:<p>DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.</p>Fórmula:C19H21N7OForma y color:SolidPeso molecular:363.42Etofamide
CAS:<p>Etofamide, an antimicrobial agent, exhibits an IC50 of 5.96 mg/L against amoebae.</p>Fórmula:C19H20Cl2N2O5Forma y color:SolidPeso molecular:427.28
