Protacs e Impurezas

ARD-266: Potent VHL-based AR degrader; degrades AR in prostate cancer cells with DC50s of 0.2-1 …

PROTAC ERα Degrader-1 is a chemical compound.

PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has …

iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.

PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) …

TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).

ERD-308, potent at 5nM, achieves >95% ER degradation in ER+ breast cancer, with DC50 of …

PROTAC MDM2 Degrader-3 uses PROTAC tech to efficiently break down MDM2 with a potent inhibitor …

AT6 is a PROTAC AT1 analog which is a highly selective bromodomain (Brd4) degrader.

KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein …

KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.

INY-03-041, a PROTAC pan-AKT degrader, targets AKT1/2/3 with IC50s: 2.0/6.8/3.5 nM; GDC-0068 + Lenalidomide fusion.

PROTAC MDM2 Degrader-1 uses PROTAC tech to break down MDM2 with an inhibitor, linker, and …

"CCT367766 is a potent PROTAC PDP targeting pirin, effective at low concentrations with IC50 of …

UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and …

BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a …

CST626 (Compound 9), a pan-IAP degrader PROTAC, effectively degrades XIAP, cIAP1, and cIAP2 in MM.1S …

IR808-TZ is a potent BRD4 BT-PROTAC degrader with potential for use in designing BT-PROTACs that …

PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with …

ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of …