Protacs e Impurezas

α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic …

PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via …

PF15, a PROTAC for FLT3-ITD, degrades FLT3 kinase. DC50: 76.7 nM; hinders FLT3-ITD+ cell growth; …

MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant …

mPEG-DSPE sodium (DSPE-mPEG2000 sodium) is a PROTAC linker belonging to PEG and is involved in …

DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease …

PROTAC PIN1 degrader-1, a targeted PROTAC for PIN1, effectively degrades PIN1 protein in MDA-MB-468 triple-negative …

DZ-837 is a PROTAC that targets the BCL6 protein. The composition of DZ-837 includes the …

PROTAC MLKL Degrader-2, a PROTAC that targets MLKL (Mixed Lineage Kinase), incorporates the PROTAC target …

HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB …

Compound 6C, a PROTAC degrader, targets CYP1B1 with IC50s (95.1 nM CYP1B1, 9838.6 nM CYP1A2) …

ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer …

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.

SHP2-D26: potent SHP2 degrader binding VHL-1/SHP2, neddylation & proteasome-dependent.

CMP98, a PROTAC, fails to degrade VHL; useful as CM11 negative control; contains two active …

MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations …

U7D-1: First-class USP7 PROTAC degrader, DC50 33 nM, anticancer, induces apoptosis in Jeko-1.

Potent cereblon degrader with a DC50 of 1.5 nM, fully degrades cereblon in MM1S cells; …

MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.

PROTAC STING Degrader-1 (Compound SP23) is a STING-targeted PROTAC degrader exhibiting a DC50 of 3.2 …