Nucleótidos

2'-O-Methylcytidine-5'-triphosphate sodium salt is a synthetic, modified nucleoside analog. It can be used as an antiviral agent and anticancer drug to inhibit viral replication and tumor growth. 2'-O-Methylcytidine-5'-triphosphate sodium salt has the ability to activate cellular DNA synthesis. This compound also inhibits RNA polymerase activity in cancer cells, which inhibits the production of proteins vital for cell division. 2'-O-Methylcytidine-5'-triphosphate sodium salt can be used as a phosphoramidite building block for the synthesis of oligonucleotides with novel structures.

Please enquire for more information about Poly(2'-O-Methyladenosine 5'-monophosphate) sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page

Pro-drug of 5-FU; anti-cancer agent

2-Thiocytidine is a nucleoside that is an intermediate in the synthesis of thiamine. It has been shown to be effective in the treatment of prostate cancer cells, which may be due to its ability to inhibit protein synthesis. 2-Thiocytidine binds to the catalytic site of ribonucleotide reductase (RR) and inhibits the enzyme's activity, thereby inhibiting DNA synthesis. This drug also has been shown to inhibit crosslinking caused by UV light or other agents that generate reactive oxygen species. 2-Thiocytidine binds to the active site of RR and prevents the formation of the enzyme-substrate complex. This binding prevents reduction of ribose into ribonucleotides and inhibits DNA synthesis.

3',5'-Di-O-acetyl-2'-deoxy-5-iodouridine is an inorganic, deoxyribonucleoside. It is the acetyl derivative of 2'-deoxy-5-iodouridine, which is an analog of uracil. 3',5'-Di-O-acetyl-2'-deoxy-5-iodouridine has been shown to have antiviral properties against herpes simplex virus type 1 (HSV1) and herpes simplex virus type 2 (HSV2) in animals. This drug also has antiangiogenic properties, inhibiting the growth of new blood vessels and tissues at the site of a tumour. Studies have shown that 3',5'-di-O acetyl 2'-deoxyuridine can be incorporated into exudates from human cancer patients and can inhibit tumor cell proliferation in vivo.

5-Chloro-2',3'-dideoxy-3'-fluorouridine is a nucleoside analog that inhibits the replication of HIV by competing with other nucleosides for incorporation into viral DNA, thereby inhibiting the production of new viruses. This drug has been shown to have an inhibitory effect on the replication of HIV and has been approved as an antiretroviral agent. 5-Chloro-2',3'-dideoxy-3'-fluorouridine is active against most HIV strains and is able to suppress viral load in patients with chronic hepatitis B or C. It also inhibits the hepatic metabolism of drugs metabolized by cytochrome P450 enzymes, such as CYP3A4 inducers. The effective dose for this drug ranges from 100 mg to 200 mg per day.

2'-Deoxyadenosine monohydrate (2'-dA) is an adenosine nucleotide that is synthesized by the enzyme adenosine kinase. It is a competitive inhibitor of phosphodiesterase and inhibits the activity of this enzyme, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis. 2'-dA has been shown to have sublethal effects on neurons at concentrations that are below those required for neuronal death and apoptosis. This may be due to its ability to inhibit the synthesis of ATP, thereby limiting the production of phosphoryl groups from ATP. The inhibition of ATP synthesis also reduces the amount of energy available for other processes within cells.