Vitaminas

<p>Stability Light Sensitive<br>Applications alpha-Tocotrienol is an antioxidant.<br></p>

<p>Applications (24S)-24,25-Epoxycholesterol is a derivative of 4β-Hydroxy Cholesterol (H917980), a metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.<br>References Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995), Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1998), Chawla, A., et al.: Science, 294, 1866 (2001), Bodin, K., et al.: J. Biol. Chem., 276, 38685 (2001),<br></p>

<p>Stability Hygroscopic! Store Under Inert Atmosphere.<br>Applications An active Biotinylation reagent.<br>References Giubellino, A., et al.: J. Med. Chem., 51, 7459 (2008), Wang, Z., et al.: Nat. Chem. Biol., 4, 557 (2008),<br></p>

<p>Applications HX 531 is a novel RXR antagonist used to enhance transactivation of PPARγ and ST 13 preadipocyte differentiation. Helps in the reduction of triglyceride content in white adipose tissue, skeletal muscle and liver.<br>References Yamauchi, T. et al.: J. Clin. Invest., 108, 1001 (2001);<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haussler, R., et al.: J. Biol. Chem., 247, 2328 (1972), Holick, M.F., Rec. Res. Canc. Res., 164, 3 (2003), Palmer, H.G., et al.: Cancer Res., 63, 7799 (2003), Welsh, J., et al.: J. Nutr., 133, 2425S (2003),<br></p>

<p>Applications The main metabolite of Vitamin D3. It has potent biological activity. Vitamin D3-sulfate had &lt;5% of the activity of vitamin D3 to mobilize Ca from bone and .apprx.1% of the ability of Vitamin D3 to stimulate Ca transport, elevate serum P, or support bone calcification.<br>References Bell, P.A., et al.: Biochem. J., et al.: 115, 663 (1969), Kumar, R.S., et al.: J. Clin. Invest., 65, 277 (1980), Reeve, L.E. , et al.: J. Biol. Chem., 256, 823 (1981), Armas, L., et al.: J. Clin. Endocrinol. Metab., 89, 5387 (2004),<br></p>

<p>Applications 17beta-Estradiol-16,16-d2 (CAS# 3188-46-3) is a useful isotopically labeled research compound.<br></p>

<p>Stability Temperature and Light Sensitive<br>Applications 3-Aminopropyl-24,25-dihydroxy Vitamin D3 is a derivative of Vitamin D3 (V676045), an important factor in maintaining bone health, and has also been associated with cardiovascular health in humans.<br>References Dawson-Hughes, B., et al.: 16, 713 (2005); Lee, J., et al: J. Am. Coll. Cardio., 52, 1949 (2008)<br></p>

<p>Applications Isotope labelled d3; 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene-d3; (Vitamin K3), precursor to various types of Vitamin K. Used as a micronutrient for livestock and pet foods.<br>References Sakamoto, S., et al.: Anal. Bioanal. Chem., 396, 2955 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Hu, W., et al.: Anal. Biochem., 398, 245 (2010),<br></p>

<p>Applications MRL-871 is a novel RORγt inhibitor, binding to a previously unidentified allosteric pocket in the RORγt LBD.<br>References Scheepstra, Marcel., et al.:Nat. Commun., 6, 8833/1 (2015); Fauber, Benjamin P., et al.: Bioorganic Med. Chem. Lett., 25, 2907 (2015);<br></p>