Vitaminas

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haussler, R., et al.: J. Biol. Chem., 247, 2328 (1972), Holick, M.F., Rec. Res. Canc. Res., 164, 3 (2003), Palmer, H.G., et al.: Cancer Res., 63, 7799 (2003), Welsh, J., et al.: J. Nutr., 133, 2425S (2003),<br></p>

<p>Applications The main metabolite of Vitamin D3. It has potent biological activity. Vitamin D3-sulfate had &lt;5% of the activity of vitamin D3 to mobilize Ca from bone and .apprx.1% of the ability of Vitamin D3 to stimulate Ca transport, elevate serum P, or support bone calcification.<br>References Bell, P.A., et al.: Biochem. J., et al.: 115, 663 (1969), Kumar, R.S., et al.: J. Clin. Invest., 65, 277 (1980), Reeve, L.E. , et al.: J. Biol. Chem., 256, 823 (1981), Armas, L., et al.: J. Clin. Endocrinol. Metab., 89, 5387 (2004),<br></p>

<p>Applications Arotinoid ethyl ester is a retinoid with a similar structure to vitamin A (R252000), and inhibits human epidermal keratinocyte RNase P activity, as well as tRNA biogenesis.<br>References Liao, W.; et al.: Zhongguo Linchuang Yaolixue Yu Zhiliaoxue, 19, 112 (2014); Papadimou, E.; et al.: Biol. Chem., 384, 457 (2003); Papadimou, E.; et al.: Skin Pharmacol. Physiol., 13, 345 (2000).<br></p>

<p>Stability Light and Temperature Sensitive<br>Applications 9-cis-13,14-Dihydroretinoic Acid, is a derivative of Retinal (R240000), corotenoid component of the visual pigments.<br>References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),<br></p>

<p>Applications MRL-871 is a novel RORγt inhibitor, binding to a previously unidentified allosteric pocket in the RORγt LBD.<br>References Scheepstra, Marcel., et al.:Nat. Commun., 6, 8833/1 (2015); Fauber, Benjamin P., et al.: Bioorganic Med. Chem. Lett., 25, 2907 (2015);<br></p>