Vitaminas

Stability Light Sensitive
Applications Isovitamin D3 is a metabolite of Vitamin D. Studies show that Isovitamin D3 is biologically active in normal rats but inactive in anephric rats.
References Holick, M.F. et al.: Science, 180, 964 (1973); Wilczek, H. et al.: Prak. Lek., 59, 794 (1979);

Stability Liight Sensitive, Temperature Sensitive
Applications Occurs preformed only in animals; metabolized from carotenoids, such β-carotene, in the intestinal mucosa. Dietary sources include liver, milk, butter, cheese, eggs and fish liver oils or as carotenois from fruits and vegetables. Stored primarily in the liver in esterified form; transported in the blood by retinol binding protein (RBP). Nutritional factor.
References Davis, M., et al.: J. Biol. Chem., 15, 167 (1913), Crouch, R.K., et al.: Photochem. Photobiol., 64, 613 (1996),

Stability Light Sensitive, Temperature Sensitive, Toxic
Applications A labelled metabolite of Vitamin D2 (V676040).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Barnes, P., et al.: J. Clin. Invest., 83, 1527 (1989), Holick, M., et al.: J. Cell Biochem., 88(2), 296 (2003), Maunsell, Z., et al.: Clin. Chem., 51, 1683 (2005),

Applications Synthetic retinoic acid receptor-α/β-selective retinoid. Antineoplastic.
References Hashimoto, Y., et al.: Jpn. J. Cancer Res., 79, 473 (1988), Mizojiri, K., et al.: Arzneim.-Forsch., 47, 59 (1997), Shinjo, K., et al.: Int. J. Hematol., 72, 470 (2000), Sanda, T., et al.: Leukemia, 19, 901 (2005),

Applications 2-O-a-D-Glucopyranosyl-L-ascorbic Acid is a useful cosmetic gel and skin cleanser.
References Aizawa, K., et al.: PCT Int. Appl. (2020), WO 2020226147 A1

Applications Precursor to verious types of Vitamin K. Used as a micronutrient for livestock and pet foods.
References Sakamoto, S., et al.: Anal. Bioanal. Chem., 396, 2955 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Hu, W., et al.: Anal. Biochem., 398, 245 (2010),

Applications Vitamin K2(5) is an analog of Vitamin K that acts as a reducing agent and also acts as an electron carrier in the electron transport chain of many bacteria. Intake of Vitamin K2(5) is associated with a reduced risk of coronary heart disease.
References Fu, Q., et al.: Biodegradation, 20, 109 (2009); Gelejinse, J., et al.: J. Nut., 134, 3100 (2004); Jiang, M., et al.: Biochemistry, 47, 3426 (2008)

Stability Light Sensitive, Temperature Sensitive
Applications Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 9 is a form of vitamin K2 which acts as a prothrombogenic agent and is also a functional electron transfer component in nitrate reductase.
References Hugenholtz, P., et al.: J. Bacteriol., 180, 4765 (1998), Ginet, N., et al.: Biochemistry, 40, 1812 (2001), Cape, J., et al.: J. Biol. Chem., 280, 34654 (2005),

Applications Pyridoxal 5-phosphate Hydrate (cas# 853645-22-4) is a useful research chemical.

Stability Hygroscopic
Applications Oxythiamine HCl (cas# 136-16-3) is a useful research chemical.

Applications Pterine-6-carboxylic Acid is a degradation product of Folic acid (F680300).
References Akhtar, M., et al.: J. Pharm. Biomed. Anal., 19, 269 (1999), Andrisano, V., et al.: J. Pharm. Biomed. Anal., 32, 983 (2003), Patro, B., et al.: Bioorg. Med. Chem. Lett., 15, 67 (2005),

Applications 4-Aminoimidazole is used as a building block for the synthesis vitamin B12-analogs via Eubacterium limosu.
References Endres, B. et al.: Biol. Chem. Hop.-Sey., 376, 595 (1995);

Stability Light Sensitive, Temperature Sensitive
Applications 25-Hydroxyvitamin D3 3-Hemisuccinate is a conjugate of 5-Hydroxyvitamin D3 (C125700), the principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25. Calcium regulator. Also used in the preparation and synthesis of antisera to be used in the immunoassay of 25-Hydroxyvitamin D3.
References Morii, et al.: Arch. Biochem. Biophys., 120, 513 (1967), Blunt, et al.: Biochemistry, 7, 3317 (1968), Liu, et al.: Science, 311, 1770 (2006),

Stability Light Sensitive
Applications Retinyl Propionate is a Vitamin A ester derivative. Retinyl Propionate is a hypermitotic agent that is used in cosmetic formulations.This compound contains an unknown cis isomer.
References Ridge, B.D. et al.: Br. J. Dermatol., 118, 167 (1988); Oblong, J.E. et al.: Cosm. Sci. Technol., Ser., 27, 441 (2005); Weisse, S. et al.: J. Drug Del. Sci. Technol., 14, 77 (2004);

Applications Used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus.
References Miyachi, Y., et al.: Br. J. Dermatol., 114, 231 (1986), Rallis, E., et al.: Drugs Exp. Clin. Res., 30, 191 (2004), Ozcan, H., et al.: Eur. J. Dermatol., 17, 313 (2007),

Applications The labelled aglucon of Daidzin.
References Am. J. Respir. Cell Mol. Biol., 7, 637 (1992), Biochim. Biophys. Acta 1221, 29 (1994), Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)

Applications (+)-Biotin 4-Amidobenzoic Acid, Sodium Salt is a fluorigenic substrate for the determination of Biotinidase activity.

Stability Hygroscopic
Applications Corotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase.
References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),

Stability Hygroscopic
Applications One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).
References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),

Stability Moisture Sensitive
Applications Succinimidyl-6-(biotinamido) Hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent
References Hofmann, K., et al.: Biochemistry, 21, 978 (1982); Leary, J.J., et al.: P. Natl. Acad. Sci. USA, 80, 4045, (1983); Suter, M., et al.: Immunology Letters, 13, 313 (1986); Gretch, D.R., et al.: Anal. Biochem., 163, 270 (1987), Burgess, T.L., et al.: J. Biol. Chem., 269 (32), 19188 (1995), Schumacher, T.N.M., et al.: Science, 271, 1854 (1996)

Cholecalciferol - 100IU/mg - contains 2.5g/kg active is a chemical compound known as vitamin D3. It is derived primarily from cholesterol through photochemical synthesis in animal skin exposed to ultraviolet light. The product functions as a hormone regulator by modulating calcium and phosphorus metabolism within biological systems. This process is crucial for maintaining bone density and immune system efficacy.

Delta-Tocotrienol is a natural compound, part of the vitamin E family, which is primarily sourced from the seeds and fruits of certain plants, such as annatto. This compound is a potent antioxidant, exerting its effects through the scavenging of free radicals and protection of polyunsaturated fatty acids in cell membranes from oxidative damage. Additionally, delta-Tocotrienol inhibits the enzyme HMG-CoA reductase, leading to a reduction in cholesterol synthesis.

Stability Temperature and Light Sensitive
Applications A metabolite of Vitamin D3.
References Bell, P.A., et al.: Biochem. J., et al.: 115, 663 (1969), Kumar, R.S., et al.: J. Clin. Invest., 65, 277 (1980), Shimada, K., et al.: Biol. Pharm. Bull., 19, 491 (1996),